{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:15:46Z","timestamp":1791656146805,"version":"4.3.4"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:00:00Z","timestamp":1495756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:00:00Z","timestamp":1495756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Hepatitis C virus (HCV) infection is the leading cause of liver disease in hemophilia patients. In those with human immunodeficiency virus (HIV)\/HCV coinfection, the rate of liver disease progression is greater than in HCV monoinfected individuals. Despite antiretroviral therapy, which slows HCV liver disease progression, some require transplantation. Whether transplant outcomes are worse in hemophilic (H) rather than nonhemophilic (NH) candidates is unknown. In order to determine rates and predictors of pretransplant and posttransplant survival, we conducted a retrospective observational study using United Network for Organ Sharing national transplant registry data, comparing HCV+\u2009H and NH candidates. We identified 2502 HCV+\u2009liver transplant candidates from 8 US university\u2010based transplant centers, between January 1, 2004 to December 31, 2010, including 144 HIV+\u2009(6%) and 2358 HIV\u2013; 36\u2009H (1%) and 2466 NH; 1213 (48%) transplanted and 1289 not transplanted. Other than male predominance and younger age, each were <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.001. Baseline data were comparable between H and NH. In univariate analysis, 90\u2010day pretransplant mortality was associated with higher baseline Model for End\u2010Stage Liver Disease (MELD; hazard ratio [HR]\u2009=\u20091.15; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.001), lower baseline platelet count (HR\u2009=\u20090.9 per 25,000\/\u00b5L; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.04), and having HIV\/HCV+\u2009hemophilia (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.003). In multivariate analysis, pretransplant mortality was associated with higher MELD (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.001) and was significantly greater in HIV+\u2009than HIV\u2013 groups (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.001). However, it did not differ between HIV+\u2009H and NH (HR\u2009=\u20091.7; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.36). Among HIV\/HCV+, posttransplant mortality was similar between H and NH, despite lower CD4 in H (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.04). In conclusion, this observational study confirms that hemophilia per se does not have a specific influence on transplant outcomes and that HIV infection increases the risk of mortality in both H and NH patients. <jats:italic toggle=\"yes\">Liver Transplantation 23 762\u2013768 2017 AASLD<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/lt.24688","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T10:38:07Z","timestamp":1481279887000},"page":"762-768","source":"Crossref","is-referenced-by-count":15,"title":["Hemophilia Liver Transplantation Observational Study"],"prefix":"10.1097","volume":"23","author":[{"given":"Margaret V.","family":"Ragni","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology,University of Pittsburgh and Hemophilia Center of Western Pennsylvania,Pittsburgh,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Humar","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Starzl Transplant Institute,University of Pittsburgh,Pittsburgh,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Stock","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery,University of California,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Eghtesad","sequence":"additional","affiliation":[{"name":"Transplant Center and Department of General Surgery, Cleveland Clinic Foundation,Cleveland,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Fung","sequence":"additional","affiliation":[{"name":"Transplant Center and Department of General Surgery, Cleveland Clinic Foundation,Cleveland,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Stosor","sequence":"additional","affiliation":[{"name":"Divisions of Infectious Diseases and Organ Transplantation,Northwestern University, Feinberg School of Medicine,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Nissen","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Cedars\u2010Sinai Medical Center,Los Angeles,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Transplant Medicine, Beth Israel Deaconess Medical Center,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Division of Digestive Disorders,University of Cincinnati,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Stablein","sequence":"additional","affiliation":[{"name":"Emmes Corporation,Baltimore,MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burc","family":"Barin","sequence":"additional","affiliation":[{"name":"Emmes Corporation,Baltimore,MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,5,26]]},"reference":[{"key":"lt24688-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1086\/319273","article-title":"Impact of human immunodeficiency virus infection on progression to end\u2010stage liver disease in individuals with hemophilia and hepatitis C infection","volume":"183","year":"2001","journal-title":"J Infect Dis"},{"key":"lt24688-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2516.2010.02366.x","article-title":"Impact of HIV on 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