{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:22:08Z","timestamp":1782346928438,"version":"3.54.5"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>The epidemiology of infections after living donor liver transplantation (LDLT) is limited. We aimed to study the epidemiology and risk factors of infections after LDLT. The medical records of 223 adult patients who underwent LDLT from January 1, 2000 to August 31, 2015 were reviewed for all infections occurring up to 1 year. We estimated the cumulative incidence of infection using the Kaplan\u2010Meier product limit method. Risk factors were analyzed with time\u2010dependent Cox regression modeling. The majority of patients were Caucasian (94.6%) and male (64.6%), and the median age at transplantation was 55 years. The most common indication for transplantation was primary sclerosing cholangitis (37.7%). A total of 122 patients developed an infection during the follow\u2010up period (1\u2010year cumulative event rate of 56%), with the majority (66%) of these occurring within 30 days after transplantation.<jats:italic toggle=\"yes\">Enterococcus sp<\/jats:italic>. was the most frequent pathogen identified. Multivariate analysis showed that increased Model for End\u2010Stage Liver Disease (MELD) score (per 10\u2010point change: hazard ratio [HR], 1.59), history of recurrent infections prior to transplant (HR, 2.01), Roux\u2010en\u2010Y anastomosis (HR, 2.37), increased log\u2010number of packed red blood cell transfusions (HR, 1.39), and biliary complications (HR, 4.26) were independently associated with a higher risk of infection. Infections occur commonly after LDLT, with most infections occurring early and being related to the hepatobiliary system. Higher MELD scores, the type of biliary anastomosis, presence of biliary complications, and prior pretransplant infections are independently associated with a higher risk for infections.<jats:italic toggle=\"yes\">Liver Transplantation 23 465\u2013477<\/jats:italic>2017 AASLD.<\/jats:p>","DOI":"10.1002\/lt.24739","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T08:31:21Z","timestamp":1486542681000},"page":"465-477","source":"Crossref","is-referenced-by-count":45,"title":["Epidemiology and risk factors for infection after living donor liver transplantation"],"prefix":"10.1097","volume":"23","author":[{"given":"Cybele Lara R.","family":"Abad","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Infectious Diseases, Philippine General Hospital,University of the Philippines,Manila,Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Lahr","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymund R.","family":"Razonable","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, The William J. Von Liebig Center for Transplantation and Clinical Regeneration,Mayo Clinic,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"lt24739-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00007890-200202270-00025","article-title":"Cost\u2010effectiveness of cadaveric and living\u2010donor liver transplantation","volume":"73","year":"2002","journal-title":"Transplantation"},{"key":"lt24739-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/hep.1840020516","article-title":"Evolution of liver transplantation","volume":"2","year":"1982","journal-title":"Hepatology"},{"key":"lt24739-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1053\/jlts.2000.18499","article-title":"Impact of liver transplantation on health\u2010related quality of life","volume":"6","year":"2000","journal-title":"Liver Transpl"},{"key":"lt24739-bib-0004-20240115","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1111\/j.1440-1746.2010.06418.x","article-title":"Does living donation have advantages over deceased donation in liver transplantation?","volume":"25","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"lt24739-bib-0005-20240115","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/00007890-199410150-00004","article-title":"Infectious complications in liver transplant recipients on tacrolimus. 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