{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:52:45Z","timestamp":1778010765820,"version":"3.51.4"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Nonselective beta\u2010blockers (NSBBs) have been the backbone for the treatment of portal hypertension in cirrhosis for the last 3 decades. A publication in 2010 of a prospective observational study suggested that NSBBs could increase mortality in patients with refractory ascites. This opened a controversy about the safety and efficacy of NSBBs in patients with advanced liver disease and led to the publication of a large corpus of observational data assessing the safety of NSBBs in patients with advanced cirrhosis. In this article, we briefly review the clinical pharmacology of NSBBs, the pathophysiological basis for the underlying benefits and harms of NSBBs in advanced cirrhosis, and the evidence in favor and against the use of NSBBs in specific scenarios. Finally, we summarize the current recommendations and propose areas of opportunity for future research.<jats:italic toggle=\"yes\">Liver Transplantation 23 1058\u20131069 2017<\/jats:italic>AASLD.<\/jats:p>","DOI":"10.1002\/lt.24794","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T16:39:26Z","timestamp":1496853566000},"page":"1058-1069","source":"Crossref","is-referenced-by-count":28,"title":["Beta\u2010blockers in patients with advanced liver disease: Has the dust settled?"],"prefix":"10.1097","volume":"23","author":[{"given":"Carlos","family":"Moctezuma\u2010Velazquez","sequence":"first","affiliation":[{"name":"Cirrhosis Care Clinic, Liver Unit, Division of Gastroenterology, Centre of Excellence for Gastrointestinal Inflammation and Immunity Research,University of Alberta,Edmonton,Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Kalainy","sequence":"additional","affiliation":[{"name":"Cirrhosis Care Clinic, Liver Unit, Division of Gastroenterology, Centre of Excellence for Gastrointestinal Inflammation and Immunity Research,University of Alberta,Edmonton,Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan G.","family":"Abraldes","sequence":"additional","affiliation":[{"name":"Cirrhosis Care Clinic, Liver Unit, Division of Gastroenterology, Centre of Excellence for Gastrointestinal Inflammation and Immunity Research,University of Alberta,Edmonton,Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"lt24794-bib-0001-20240122","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension","volume":"63","year":"2015","journal-title":"J 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