{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:43:10Z","timestamp":1761896590256},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Split\u2010liver transplantation has been proposed as an alternative to whole liver (WL) transplantation to expand the donor pool, but studies comparing adult longterm outcomes between the 2 methods are conflicting and limited. This is the first Italian multicenter study that retrospectively analyzed 119 matched\u2010pair recipients of whole and extended right grafts (ERGs) for longterm survival outcomes. In the overall population, WL recipients showed higher patient survival at 1 (93% versus 73%), 5 (87% versus 65%), and 10 years (83% versus 60%) after transplantation compared with split\u2010liver recipients (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.001); graft survivals of WL recipients were also superior at 1 (90% versus 76%), 5 (84% versus 57%), and 10 years (81% versus 52%) posttransplant (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.001). However, among the 81 matched pairs that survived the first posttransplant year, 5\u2010 and 10\u2010year patient survivals were 90% and 81% for split recipients and 99% and 96% for whole recipients, respectively (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.34). The 5\u2010 and 10\u2010year graft survivals were also comparable: 87% and 77% for split recipients, and 86% and 82% for whole recipients (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.86). Cox regression analysis identified donor age &gt;50, donor\u2010to\u2010recipient weight ratio\u2009&lt;\u20091, retransplantation status, and United Network for Organ Sharing I\u2010IIA status as risk factors for partial graft use. There were no significant differences in 5\u2010year outcomes based on center volume. In conclusion, we demonstrate that adult liver transplantation with ERGs can achieve longterm success comparable with that of whole grafts in appropriate patients but should be selectively used in patients with risk factors. <jats:italic toggle=\"yes\">Liver Transplantation 23 1384\u20131395 2017<\/jats:italic> AASLD.<\/jats:p>","DOI":"10.1002\/lt.24808","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T11:58:37Z","timestamp":1498478317000},"page":"1384-1395","source":"Crossref","is-referenced-by-count":25,"title":["A matched pair analysis of multicenter longterm follow\u2010up after split\u2010liver transplantation with extended right grafts"],"prefix":"10.1097","volume":"23","author":[{"given":"Mitchell W.","family":"Ross","sequence":"first","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Cescon","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences,University of Bologna,Bologna,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Angelico","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Ges\u00f9, Children's Research Hospital, Istituto di Ricovero e Cura a Carattere Scientifico,Rome,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Andorno","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery, San Martino Hospital,University of Genoa,Genoa,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Rossi","sequence":"additional","affiliation":[{"name":"Division of Liver Transplantation, Ca' Granda Maggiore Hospital,Milan,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Pinna","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences,University of Bologna,Bologna,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"De Carlis","sequence":"additional","affiliation":[{"name":"Department of Multi\u2010Disciplinary Surgery, Division of General, HBP and Transplantation Surgery, Niguarda Transplant Center, Niguarda Hospital,Milano\u2010Bicocca University,Milan,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Baccarani","sequence":"additional","affiliation":[{"name":"Division of Liver Transplant, Department of Medical and Biological Sciences, University Hospital of Udine,Udine,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Cillo","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation,University of Padua,Padua,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Colledan","sequence":"additional","affiliation":[{"name":"Division of Liver and Small Bowel Transplantation, Azienda Ospedaliera Papa Giovanni XXIII,Bergamo,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Mazzaferro","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal Surgery and Liver Transplantation, Istituto Nazionale Tumori of Milano, Istituto di Ricovero e Cura a Carattere Scientifico Foundation,University of Milan,Milan,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Tisone","sequence":"additional","affiliation":[{"name":"Division of Organ Transplantation,Tor Vergata University,Rome,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Organ Transplantation,Umberto I Hospital, Sapienza University,Rome,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Tuzzolino","sequence":"additional","affiliation":[{"name":"Information Technology Department,Mediterranean Institute for Transplantation and Advanced Specialized Therapies,Palermo,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duilio","family":"Pagano","sequence":"additional","affiliation":[{"name":"Department for the Study of Abdominal Diseases and Abdominal Transplantation, Istituto di Ricovero e Cura a Carattere Scientifico\u2013Mediterranean Institute for Transplantation and Advanced Specialized Therapies,Palermo,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Gruttadauria","sequence":"additional","affiliation":[{"name":"Department for the Study of Abdominal Diseases and Abdominal Transplantation, Istituto di Ricovero e Cura a Carattere Scientifico\u2013Mediterranean Institute for Transplantation and Advanced Specialized Therapies,Palermo,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Mazariegos","sequence":"additional","affiliation":[{"name":"Division of Pediatric Transplantation, Children's Hospital of Pittsburgh,Pittsburgh,PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Gridelli","sequence":"additional","affiliation":[{"name":"Department for the Study of Abdominal Diseases and Abdominal Transplantation, Istituto di Ricovero e Cura a Carattere Scientifico\u2013Mediterranean Institute for Transplantation and Advanced Specialized Therapies,Palermo,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Spada","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Ges\u00f9, Children's Research Hospital, Istituto di Ricovero e Cura a Carattere Scientifico,Rome,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"lt24808-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/01.sla.0000247254.76747.f3","article-title":"Long term outcome of split liver transplantation using right extended grafts in adulthood: a matched pair analysis","volume":"244","year":"2006","journal-title":"Ann Surg"},{"key":"lt24808-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1477-2574.2011.00360.x","article-title":"Outcomes in partial liver transplantation: deceased donor 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