{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:57:55Z","timestamp":1773925075125,"version":"3.50.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>The salvage liver transplantation (LT) strategy was conceived for initially resectable and transplantable hepatocellular carcinoma (HCC) to obviate upfront transplantation, with salvage LT in the case of recurrence. The longterm outcomes of a second resection for recurrent HCC have improved. The aim of this study was to perform an intention\u2010to\u2010treat analysis of overall survival (OS) comparing these 2 strategies for initially resectable and transplantable recurrent HCC. From 1994 to 2011, 391 patients with HCC who underwent salvage LT (n\u2009=\u200977) or a second resection (n\u2009=\u2009314) were analyzed. Of 77 patients in the salvage LT group, 21 presented with resectable and transplantable recurrent HCC and 18 underwent transplantation. Of 314 patients in the second resection group, 81 presented with resectable and transplantable recurrent HCC and 81 underwent a second resection. The 5\u2010year intention\u2010to\u2010treat OS rates, calculated from the time of primary hepatectomy, were comparable between the 2 strategies (72% for salvage transplantation versus 77% for second resection; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.57). In patients who completed the salvage LT or second resection procedure, the 5\u2010year OS rates, calculated from the time of the second surgery, were comparable between the 2 strategies (71% versus 71%; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.99). The 5\u2010year disease\u2010free survival (DFS) rates were 72% following transplantation and 18% following the second resection (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.001). Similar results were observed after propensity score matching. In conclusion, although the 5\u2010year OS rates were similar in the salvage LT and second resection groups, the salvage LT strategy still achieves better DFS. Second resection for recurrent HCC might be considered to be the best alternative option to LT in the current organ shortage. <jats:italic toggle=\"yes\">Liver Transplantation 23 1553\u20131563 2017<\/jats:italic> AASLD.<\/jats:p>","DOI":"10.1002\/lt.24952","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T16:37:46Z","timestamp":1506357466000},"page":"1553-1563","source":"Crossref","is-referenced-by-count":58,"title":["Salvage liver transplantation or repeat hepatectomy for recurrent hepatocellular carcinoma: An intent\u2010to\u2010treat analysis"],"prefix":"10.1097","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-2572","authenticated-orcid":false,"given":"Chetana","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation and,Henri Mondor Hospital, AP\u2010HP, Paris\u2010Est University,Cr\u00e9teil,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroji","family":"Shinkawa","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine,University of Tokyo,Tokyo,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine,University of Tokyo,Tokyo,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant","family":"Bhangui","sequence":"additional","affiliation":[{"name":"Medanta Institute of Liver Transplantation and Regenerative Medicine,New Delhi,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chady","family":"Salloum","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation and,Henri Mondor Hospital, AP\u2010HP, Paris\u2010Est University,Cr\u00e9teil,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepcion","family":"Gomez Gavara","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation and,Henri Mondor Hospital, AP\u2010HP, Paris\u2010Est University,Cr\u00e9teil,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eylon","family":"Lahat","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation and,Henri Mondor Hospital, AP\u2010HP, Paris\u2010Est University,Cr\u00e9teil,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohiko","family":"Omichi","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine,University of Tokyo,Tokyo,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Arita","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine,University of Tokyo,Tokyo,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine,University of Tokyo,Tokyo,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Compagnon","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation and,Henri Mondor Hospital, AP\u2010HP, Paris\u2010Est University,Cr\u00e9teil,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrille","family":"Feray","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Henri Mondor Hospital, AP\u2010HP, Paris\u2010Est University,Cr\u00e9teil,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Kokudo","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine,University of Tokyo,Tokyo,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Azoulay","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation and,Henri Mondor Hospital, AP\u2010HP, Paris\u2010Est 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