{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:51:44Z","timestamp":1783691504707,"version":"3.55.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>The purpose of this study is to determine whether magnetic resonance (MR)\u2013proton density fat fraction (PDFF) estimate of negligible hepatic fat percentage (&lt;5%) can exclude significant hepatic steatosis (\u226510%) in living liver donor candidates obviating the need for liver biopsy and to perform intraindividual comparisons between MR\u2010PDFF techniques for hepatic steatosis quantification. In an ethics\u2010approved retrospective study, 144 liver donor candidates with magnetic resonance spectroscopy (MRS) and 6\u2010echo Dixon magnetic resonance imaging (MRI) between 2013 and 2015 were included. A subset of 32 candidates underwent liver biopsy. Hepatic fat percentage was determined using MR\u2010PDFF and histopathology\u2010determined fat fraction as the reference standard. A receiver operating characteristic analysis with positive predictive value, negative predictive value (NPV), sensitivity, and specificity was performed to discriminate between clinically significant steatosis (\u226510%) or not (&lt;10%) at MRS\u2010PDFF and MRI\u2010PDFF thresholds of 5% and 10%. Pearson correlation and Bland\u2010Altman analyses between MRS\u2010PDFF and MRI\u2010PDFF were performed for intraindividual comparison of hepatic steatosis estimation. There was significant association between MRS\u2010PDFF and MRI\u2010PDFF with HP\u2010FP. High NPV of 95% (95% confidence interval [CI], 78%\u201099%) and 100% (95% CI, 76%\u2010100%) as well as an area under the curve of 0.90 (95% CI, 0.79\u20101.0) and 0.93 (95% CI, 0.84\u20101.0) were obtained with a cutoff threshold of 5% MRI\u2010PDFF and MRS\u2010PDFF, respectively, to exclude clinically significant steatosis (\u226510%). Intraindividual comparison between MRS\u2010PDFF and MRI\u2010PDFF showed a Pearson correlation coefficient of 0.83. Bland\u2010Altman analysis showed a mean difference of 1% with 95% limits of agreement between \u22121% and 3%. MR\u2010PDFF estimate of negligible hepatic fat percentage (&lt;5%) has sufficient NPV for excluding clinically significant hepatic steatosis (\u226510%) in living liver donor candidates obviating the need for liver biopsy. It may be sufficient to acquire only the multiecho Dixon MRI\u2010PDFF for hepatic steatosis estimation. <jats:italic toggle=\"yes\">Liver Transplantation 24 470\u2013477 2018<\/jats:italic> AASLD.<\/jats:p>","DOI":"10.1002\/lt.24965","type":"journal-article","created":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T08:52:42Z","timestamp":1509180762000},"page":"470-477","source":"Crossref","is-referenced-by-count":34,"title":["Can negligible hepatic steatosis determined by magnetic resonance imaging\u2013proton density fat fraction obviate the need for liver biopsy in potential liver donors?"],"prefix":"10.1097","volume":"24","author":[{"given":"Janakan","family":"Satkunasingham","sequence":"first","affiliation":[{"name":"Joint Department of Medical Imaging,University of Toronto,Toronto,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hooman Hosseini","family":"Nik","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging,University of Toronto,Toronto,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Health Network,University of Toronto,Toronto,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Menezes","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging,University of Toronto,Toronto,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia","family":"Selzner","sequence":"additional","affiliation":[{"name":"Multi\u2010Organ Transplant Program,Toronto General Hospital,Toronto,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Cattral","sequence":"additional","affiliation":[{"name":"Division of General Surgery,Toronto General Hospital,Toronto,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grant","sequence":"additional","affiliation":[{"name":"Division of General Surgery,Toronto General Hospital,Toronto,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik","family":"Jhaveri","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging,University of Toronto,Toronto,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"lt24965-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-2001-12933","article-title":"Fatty liver in liver transplantation and surgery","volume":"21","year":"2001","journal-title":"Semin Liver Dis"},{"key":"lt24965-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jhep.2007.02.007","article-title":"Prevalence and risk 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