{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T21:33:08Z","timestamp":1783373588305,"version":"3.54.6"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Common variable immunodeficiency (CVID) is the most common form of primary immunodeficiency characterized by antibody deficiency, recurrent bacterial infections, and autoimmunity. Advanced chronic liver disease occurs in a subset of patients with CVID and manifests with various histological features, such as nodular regenerative hyperplasia, inflammation, fibrosis, and cholangiopathy. We present a case series characterizing the outcomes in adult patients transplanted for primary CVID\u2010related liver disease. We discuss the unique transplantation challenges faced in this primary immunodeficiency group including susceptibility to infections and early disease recurrence. There is a statistically significant decrease in 3\u2010year and 5\u2010year survival after liver transplantation in those with CVID\u2010related liver disease (55% at 3 and 5 years) compared with all\u2010comers (89% at 3 years, 81% at 5 years), prompting a need for discussion of suitability of transplantation in this group of patients as well as methods for reducing posttransplantation risk such as scrupulous search for infectious agents and reduction of immunosuppression. <jats:italic toggle=\"yes\">Liver Transplantation 24 171\u2013181 2018<\/jats:italic> AASLD.<\/jats:p>","DOI":"10.1002\/lt.24979","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T23:02:39Z","timestamp":1511218959000},"page":"171-181","source":"Crossref","is-referenced-by-count":52,"title":["Liver transplantation in adults with liver disease due to common variable immunodeficiency leads to early recurrent disease and poor outcome"],"prefix":"10.1097","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-7677","authenticated-orcid":false,"given":"Vian","family":"Azzu","sequence":"first","affiliation":[{"name":"The Liver Unit,Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust,Cambridge,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua E.","family":"Elias","sequence":"additional","affiliation":[{"name":"The Liver Unit,Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust,Cambridge,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Duckworth","sequence":"additional","affiliation":[{"name":"Department of Histopathology,Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust,Cambridge,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Histopathology,Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust,Cambridge,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Brais","sequence":"additional","affiliation":[{"name":"Department of Histopathology,Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust,Cambridge,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinakantha S.","family":"Kumararatne","sequence":"additional","affiliation":[{"name":"Department of Immunology,Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust,Cambridge,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander E. S.","family":"Gimson","sequence":"additional","affiliation":[{"name":"The Liver Unit,Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust,Cambridge,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J. 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