{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:14:31Z","timestamp":1773080071944,"version":"3.50.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>The goal of the study is to characterize the relationship between portal vein thrombosis (PVT) and hepatic atrophy in patients without cirrhosis and the effect of various types of surgical shunts on liver regeneration and splenomegaly. Patients without cirrhosis with PVT suffer from presinusoidal portal hypertension, and often hepatic atrophy is a topic that has received little attention. We hypothesized that patients with PVT have decreased liver volumes, and shunts that preserve intrahepatic portal flow enhance liver regeneration. Sixty\u2010four adult and pediatric patients with PVT who underwent surgical shunt placement between 1998 and 2011 were included in a retrospective study. Baseline liver volumes from adult patients were compared with standard liver volume (SLV) as well as a group of healthy controls undergoing evaluation for liver donation. Clinical assessment, liver function tests, and liver and spleen volumes from cross\u2010sectional imaging were compared before and after surgery. A total of 40 patients received portal flow\u2013preserving shunts (32 mesoportal and 8 selective splenorenal), whereas 24 received portal flow\u2013diverting shunts (16 nonselective splenorenal and 8 mesocaval). Baseline adult liver volumes were 26% smaller than SLV (1248 versus 1624 cm<jats:sup>3<\/jats:sup>;<jats:italic toggle=\"yes\">P<\/jats:italic>= 0.02) and 20% smaller than the control volumes (1248 versus 1552 cm<jats:sup>3<\/jats:sup>;<jats:italic toggle=\"yes\">P<\/jats:italic>= 0.02). Baseline adult spleen volumes were larger compared with controls (1258 versus 229 cm<jats:sup>3<\/jats:sup>;<jats:italic toggle=\"yes\">P<\/jats:italic>&lt; 0.001). Preserving shunts were associated with significant increase in liver volumes (886 versus 1131 cm<jats:sup>3<\/jats:sup>;<jats:italic toggle=\"yes\">P<\/jats:italic>= 0.01), whereas diverting shunts were not. Diverting shunts significantly improved splenomegaly. In conclusion, we have demonstrated that patients without cirrhosis with PVT have significant liver atrophy and splenomegaly. Significant liver regeneration was achieved after portal flow\u2013preserving shunts.<jats:italic toggle=\"yes\">Liver Transplantation 24 881\u2013887 2018<\/jats:italic>AASLD.<\/jats:p>","DOI":"10.1002\/lt.25024","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T22:20:45Z","timestamp":1517264445000},"page":"881-887","source":"Crossref","is-referenced-by-count":11,"title":["Liver atrophy and regeneration in noncirrhotic portal vein thrombosis: Effect of surgical shunts"],"prefix":"10.1097","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6606-2496","authenticated-orcid":false,"given":"Abdulrhman S.","family":"Elnaggar","sequence":"first","affiliation":[{"name":"Center for Liver Disease and Transplantation, Department of Surgery, Columbia University College of Physicians and Surgeons,New York\u2010Presbyterian Hospital,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam D.","family":"Griesemer","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation, Department of Surgery, Columbia University College of Physicians and Surgeons,New York\u2010Presbyterian Hospital,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Bentley\u2010Hibbert","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation, Department of Surgery, Columbia University College of Physicians and Surgeons,New York\u2010Presbyterian Hospital,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation, Department of Surgery, Columbia University College of Physicians and Surgeons,New York\u2010Presbyterian Hospital,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Martinez","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation, Department of Surgery, Columbia University College of Physicians and Surgeons,New York\u2010Presbyterian Hospital,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Lobritto","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation, Department of Surgery, Columbia University College of Physicians and Surgeons,New York\u2010Presbyterian Hospital,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Kato","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation, Department of Surgery, Columbia University College of Physicians and Surgeons,New York\u2010Presbyterian Hospital,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean C.","family":"Emond","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation, Department of Surgery, Columbia University College of Physicians and Surgeons,New York\u2010Presbyterian Hospital,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"lt25024-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.3748\/wjg.v12.i13.2115","article-title":"Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies","volume":"12","year":"2006","journal-title":"World J Gastroenterol"},{"key":"lt25024-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0168-8278(00)80259-7","article-title":"Portal vein thrombosis in adults: pathophysiology, pathogenesis and 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