{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:59:34Z","timestamp":1783353574729,"version":"3.54.6"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Liver transplantation (LT) is the standard treatment for biliary atresia (BA) patients with end\u2010stage liver disease. The prognosis after LT has steadily improved, but overall prognosis of BA patients is also determined by mortality before LT. We aimed to quantify mortality in young BA patients on the Eurotransplant waiting list and to determine the effect of disease severity and age at time of listing on pretransplant mortality. We used a cohort study design, which incorporated data from the Eurotransplant registry. Participants were 711 BA patients who were below 5 years of age from 5 countries and listed for LT between 2001 and 2014. We applied a competing risk analysis to evaluate simultaneously the outcomes death, LT, and still waiting for a suitable organ. We used Cox proportional hazards regression to assess 2\u2010year mortality. In a subcohort of 416 children, we performed multivariate analyses between 2\u2010year mortality and disease severity or age, each at listing. Disease severity at listing was quantified by the Model for End\u2010Stage Liver Disease (MELD) score, which assesses bilirubin, creatinine, albumin, and international normalized ratio as continuous variables. Two\u2010year wait\u2010list mortality was 7.9%. Age below 6 months and MELD score above 20 points, each at listing, were strongly and independently associated with 2\u2010year mortality (each <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). A total of 21% of infants who fulfilled both criteria did not survive the first 6 months on the waiting list. In conclusion, our findings quantify mortality among young BA patients on the waiting list and the relative importance of risk factors (age and severity of disease at listing). Our results provide both an evidence base to rationally address high mortality in subgroups and a methodology to assess effects of implemented changes, for example, in allocation rules. <jats:italic toggle=\"yes\">Liver Transplantation 24 810\u2013819 2018<\/jats:italic> AASLD.<\/jats:p>","DOI":"10.1002\/lt.25025","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T17:21:53Z","timestamp":1517246513000},"page":"810-819","source":"Crossref","is-referenced-by-count":33,"title":["Wait\u2010list mortality of young patients with Biliary atresia: Competing risk analysis of a eurotransplant registry\u2013based cohort"],"prefix":"10.1097","volume":"24","author":[{"given":"Hubert P. J.","family":"van der Doef","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Hepatology and Nutrition, University Medical Center Groningen,University of Groningen,Groningen,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick F.","family":"van Rheenen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Hepatology and Nutrition, University Medical Center Groningen,University of Groningen,Groningen,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"van Rosmalen","sequence":"additional","affiliation":[{"name":"Eurotransplant,Leiden,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Rogiers","sequence":"additional","affiliation":[{"name":"Eurotransplant,Leiden,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henkjan J.","family":"Verkade","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Hepatology and Nutrition, University Medical Center Groningen,University of Groningen,Groningen,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for pediatric liver transplantation centers of Eurotransplant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"lt25025-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jhep.2016.04.032","article-title":"Biliary atresia and other cholestatic childhood diseases: advances and future challenges","volume":"65","year":"2016","journal-title":"J Hepatol"},{"key":"lt25025-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/MPG.0000000000000986","article-title":"Liver transplantation for biliary atresia: is there a difference in outcome for infants?","volume":"62","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"lt25025-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1399-3046.2010.01450.x","article-title":"Mortality of biliary atresia in children not undergoing liver transplantation in the Netherlands","volume":"15","year":"2011","journal-title":"Pediatr Transplant"},{"key":"lt25025-bib-0004-20240115","first-page":"264015","article-title":"Experience since MELD implementation: how does the new system deliver?","volume":"2012","year":"2012","journal-title":"Int J Hepatol"},{"key":"lt25025-bib-0006-20240115","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/hep.21025","article-title":"Deaths on the liver transplant waiting list: an analysis of competing risks","volume":"43","year":"2006","journal-title":"Hepatology"},{"key":"lt25025-bib-0007-20240115","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jpeds.2005.04.073","article-title":"Biliary atresia: clinical profiles, risk factors, and outcomes of 755 patients listed for liver transplantation","volume":"147","year":"2005","journal-title":"J Pediatr"},{"key":"lt25025-bib-0008-20240115","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1002\/sim.2712","article-title":"Tutorial in biostatistics: competing risks and multi\u2010state models","volume":"26","year":"2007","journal-title":"Stat Med"},{"key":"lt25025-bib-0011-20240115","first-page":"2","article-title":"Impaired intention\u2010to\u2010treat survival after listing for liver transplantation in children with biliary atresia compared to other chronic liver diseases: 20 years' experience from the Nordic countries","volume":"21","year":"2017","journal-title":"Pediatr Transplant"},{"key":"lt25025-bib-0012-20240115","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/lt.24605","article-title":"A 10\u2010year United Network for Organ Sharing review of mortality and risk factors in young children awaiting liver transplantation","volume":"22","year":"2016","journal-title":"Liver Transpl"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.25025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201806000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T20:12:40Z","timestamp":1705263160000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201806000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.25025","relation":{},"ISSN":["1527-6465","1527-6473"],"issn-type":[{"value":"1527-6465","type":"print"},{"value":"1527-6473","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}