{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:48:13Z","timestamp":1758638893891},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>In kidney\u2010alone recipients, dual\u2010kidney transplantation using \u201chigher\u2010risk\u201d donor organs has shown outcomes comparable to those of single\u2010kidney transplantation using extended criteria donor (ECD) organs. To investigate the feasibility of a similar approach with combined kidney\u2010liver transplantation, we identified 22 dual\u2010kidney liver transplantations (DKLTs) and 3044 single\u2010kidney liver transplantations (SKLTs) performed in the United States between 2002 and 2012 using United Network for Organ Sharing\/Organ Procurement and Transplantation Network registry data. We compared donor\/recipient characteristics as well as graft\/recipient survival between DKLT recipients and SKLT recipients of \u201chigher\u2010risk\u201d kidneys (ECD and high kidney donor profile index [KDPI; &gt;85%] donors). Despite having overall similar donor and recipient characteristics compared with both \u201chigher\u2010risk\u201d donor groups, recipient survival in the DKLT group at 36 months was markedly inferior at 40.9% (compared with 67.5% for ECD SKLT recipients and 64.5% for high\u2010KDPI SKLT recipients); nondeath\u2010censored graft survival did not differ. Death was the most common cause of graft loss in all groups. Contrary to dual\u2010kidney transplantation data in kidney\u2010alone recipients, DKLT recipients in our study had inferior survival when compared with SKLT recipients of \u201chigher\u2010risk\u201d donor kidneys. These findings would suggest that dual kidney\u2010liver transplantation has an uncertain role as a strategy to expand the existing kidney donor pool in combined transplantation.<\/jats:p>","DOI":"10.1002\/lt.25045","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T16:47:41Z","timestamp":1519922861000},"page":"1570-1577","source":"Crossref","is-referenced-by-count":7,"title":["Combined Dual\u2010Kidney Liver Transplantation in the United States: A Review of United Network for Organ Sharing\/Organ Procurement and Transplantation Network Data Between 2002 and 2012"],"prefix":"10.1097","volume":"24","author":[{"given":"Grigoriy","family":"Shekhtman","sequence":"first","affiliation":[{"name":"Department of Medicine, David Geffen School of Medicine,University of California,Los Angeles,Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund","family":"Huang","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center,Los Angeles,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel M.","family":"Danovitch","sequence":"additional","affiliation":[{"name":"Department of Medicine, David Geffen School of Medicine,University of California,Los Angeles,Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Medicine,University of Miami Miller School of Medicine and the Miami Veterans Administration Hospital,Miami,FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suphamai","family":"Bunnapradist","sequence":"additional","affiliation":[{"name":"Department of Medicine, David Geffen School of Medicine,University of California,Los Angeles,Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"lt25045-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1111\/j.1600-6143.2012.04190.x","article-title":"Simultaneous liver\u2010kidney transplantation summit: current state and future directions","volume":"12","year":"2012","journal-title":"Am J Transplant"},{"key":"lt25045-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/TP.0b013e318168476d","article-title":"Declining outcomes in simultaneous liver\u2010kidney transplantation in the MELD era: ineffective usage of renal allografts","volume":"85","year":"2008","journal-title":"Transplantation"},{"key":"lt25045-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/lt.24189","article-title":"Propensity score\u2010based survival benefit of simultaneous liver\u2010kidney transplant over liver transplant alone for recipients with pretransplant renal dysfunction","volume":"22","year":"2016","journal-title":"Liver Transpl"},{"key":"lt25045-bib-0004-20240115","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/lt.23440","article-title":"Recipient survival and graft survival are not diminished by simultaneous liver\u2010kidney transplantation: an analysis of the united network for organ sharing database","volume":"18","year":"2012","journal-title":"Liver Transpl"},{"key":"lt25045-bib-0005-20240115","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/ajt.13631","article-title":"Simultaneous liver\u2010kidney allocation policy: a proposal to optimize appropriate utilization of scarce resources","volume":"16","year":"2016","journal-title":"Am J Transplant"},{"key":"lt25045-bib-0006-20240115","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1097\/01.tp.0000266579.11595.95","article-title":"Dual kidney transplantation: a case\u2010control comparison with single 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