{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:13:51Z","timestamp":1790604831209,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    Acute kidney injury (AKI) after liver transplantation (LT) is a common event, but its pathogenesis remains unclear. The aim of this prospective study is to investigate the potential relationship between postreperfusion gene expression, serum mediators, and the onset of AKI after LT. Sixty\u2010five consecutive patients undergoing LT were included in the study. Reverse transcription polymerase chain reaction (PCR) was performed on liver biopsies. Gene expression of 23 genes involved in ischemia\/reperfusion injury (IRI) was evaluated. The serum concentrations of endothelin (ET)\u20131 and inflammatory cytokines were analyzed. AKI after LT developed in 21 (32%) recipients (AKI group). Reverse transcription PCR of reperfusion biopsy in the AKI group showed higher expression of several genes involved in IRI compared with the non\u2010AKI group. Fold changes in the gene expression of ET\u20101, interleukin (IL) 18, and tumor necrosis factor \u03b1 (TNF\u2010\u03b1) were associated with creatinine peak value. AKI patients also had significantly higher ET\u20101, IL18, and TNF\u2010\u03b1 postoperative serum levels. Multivariate analysis showed that ET\u20101 (odds ratio [OR], 16.7; 95% confidence interval [CI], 3.34\u201083.42;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.001) and IL18 (OR, 5.27; 95% CI, 0.99\u201027.82,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.048) serum levels on postoperative day 1 were independently predictive of AKI. Receiver operating characteristic analysis demonstrated that the combination of biomarkers ET\u20101+IL18 was highly predictive of AKI (area under the receiver operating characteristic curve, 0.91; 95% CI, 0.83\u20100.99). Early allograft dysfunction and chronic kidney disease stage \u2265 2 occurred more frequently in AKI patients. These results suggest that the graft itself, rather than intraoperative hemodynamic instability, plays a main role in AKI after LT. These data may have mechanistic and diagnostic implications for AKI after LT.\n                    <jats:italic toggle=\"yes\">Liver Transplantation 24 922\u2013931 2018<\/jats:italic>\n                    AASLD.\n                  <\/jats:p>","DOI":"10.1002\/lt.25178","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T12:33:46Z","timestamp":1524486826000},"page":"922-931","source":"Crossref","is-referenced-by-count":16,"title":["Molecular profiling of postreperfusion milieu determines acute kidney injury after liver transplantation: A prospective study"],"prefix":"10.1097","volume":"24","author":[{"given":"Carlo","family":"Pulitano","sequence":"first","affiliation":[{"name":"Centenary Research Institute,University of Sydney,Sydney,New South Wales,Australia"},{"name":"Australian National Liver Transplantation Unit,Royal Prince Alfred Hospital,Camperdown,New South Wales,Australia"},{"name":"Center for Advanced Research in Liver Pancreas Biliary Surgery,Sydney,New South Wales,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phong","family":"Ho","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplantation Unit,Royal Prince Alfred Hospital,Camperdown,New South Wales,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Verran","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplantation Unit,Royal Prince Alfred Hospital,Camperdown,New South Wales,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charbel","family":"Sandroussi","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplantation Unit,Royal Prince Alfred Hospital,Camperdown,New South Wales,Australia"},{"name":"Center for Advanced Research in Liver Pancreas Biliary Surgery,Sydney,New South Wales,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Joseph","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplantation Unit,Royal Prince Alfred Hospital,Camperdown,New South Wales,Australia"},{"name":"Center for Advanced Research in Liver Pancreas Biliary Surgery,Sydney,New South Wales,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Bowen","sequence":"additional","affiliation":[{"name":"Centenary Research Institute,University of Sydney,Sydney,New South Wales,Australia"},{"name":"Australian National Liver Transplantation Unit,Royal Prince Alfred Hospital,Camperdown,New South Wales,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey W.","family":"McCaughan","sequence":"additional","affiliation":[{"name":"Centenary Research Institute,University of Sydney,Sydney,New South Wales,Australia"},{"name":"Australian National Liver Transplantation Unit,Royal Prince Alfred Hospital,Camperdown,New South Wales,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Crawford","sequence":"additional","affiliation":[{"name":"Australian National Liver Transplantation Unit,Royal Prince Alfred Hospital,Camperdown,New South Wales,Australia"},{"name":"Center for Advanced Research in Liver Pancreas Biliary Surgery,Sydney,New South Wales,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Shackel","sequence":"additional","affiliation":[{"name":"Centenary Research Institute,University of Sydney,Sydney,New South Wales,Australia"},{"name":"Australian National Liver Transplantation Unit,Royal Prince Alfred Hospital,Camperdown,New South Wales,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,7,23]]},"reference":[{"key":"lt25178-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"9314","DOI":"10.3748\/wjg.v22.i42.9314","article-title":"Acute kidney injury and post\u2010reperfusion syndrome in liver transplantation","volume":"22","year":"2016","journal-title":"World J Gastroenterol"},{"key":"lt25178-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/ajt.13527","article-title":"Early allograft dysfunction after liver transplantation is associated with short\u2010 and long\u2010term kidney function impairment","volume":"16","year":"2016","journal-title":"Am J Transplant"},{"key":"lt25178-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00024382-199601000-00008","article-title":"Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell 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