{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:51:17Z","timestamp":1773384677387,"version":"3.50.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Liver transplantation (LT) has a demonstrated survival benefit in select patients with severe acute alcoholic hepatitis (SAH) who do not respond to steroids, but prior studies suggest low adoption among US LT centers. Our study explored current perceptions and practice patterns of LT for SAH in the United States. We administered a Web\u2010based survey to medical directors of US LT centers between May and October of 2017 to characterize practice patterns and perceptions of LT for SAH. We obtained responses from 45 (41.3%) of 109 surveyed centers, representing all 11 (100%) United Network for Organ Sharing regions. Half (n = 23; 51.1%) reported performing at least 1 LT for SAH, although most (n = 19; 82.6%) of those had performed \u22645 LTs for that indication. Centers expressed near consensus for selection criteria, requiring strong social support (100%), no prior presentations with SAH (91.3%), absence of a severe coexisting psychiatric disorder (91.3%), and official psychosocial evaluation (87.0%). Reported posttransplant survival of SAH patients was excellent, with 17 (73.9%) centers reporting 1\u2010year posttransplant survival exceeding 90%. Among centers that had not performed LT for SAH, the most commonly cited reason was perceived high risk of alcohol relapse. In conclusion, our data demonstrate that LT is increasingly adopted as a therapeutic intervention for patients with SAH and that careful selection allows for excellent 1\u2010year posttransplant survival. Despite this, nearly half of US centers do not perform LT for this indication due to perceived high risk of alcohol relapse. Our data support the use of LT for well\u2010selected patients with SAH.<\/jats:p>","DOI":"10.1002\/lt.25285","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T02:14:26Z","timestamp":1535076866000},"page":"1357-1362","source":"Crossref","is-referenced-by-count":37,"title":["Survey of Liver Transplantation Practices for Severe Acute Alcoholic Hepatitis\u2020"],"prefix":"10.1097","volume":"24","author":[{"given":"Saroja","family":"Bangaru","sequence":"first","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm P.","family":"MacConmara","sequence":"additional","affiliation":[{"name":"Division of Surgical Transplantation, Department of Surgery,University of Texas Southwestern Medical Center,Dallas,TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit G.","family":"Singal","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjmand R.","family":"Mufti","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"lt25285-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/lt.22294","article-title":"Adherence in liver transplant recipients","volume":"17","year":"2011","journal-title":"Liver Transpl"},{"key":"lt25285-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.3748\/wjg.v19.i36.5953","article-title":"Liver transplantation in alcoholic liver disease current status and controversies","volume":"19","year":"2013","journal-title":"World J Gastroenterol"},{"key":"lt25285-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0016-5085(78)90401-8","article-title":"Corticosteroid therapy of alcoholic hepatitis","volume":"75","year":"1978","journal-title":"Gastroenterology"},{"key":"lt25285-bib-0004-20240115","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic hepatitis","volume":"360","year":"2009","journal-title":"N Engl J Med"},{"key":"lt25285-bib-0005-20240115","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cld.2012.08.005","article-title":"Diagnosis and management of alcoholic hepatitis","volume":"16","year":"2012","journal-title":"Clin Liver Dis"},{"key":"lt25285-bib-0006-20240115","doi-asserted-by":"crossref","first-page":"685","DOI":"10.7326\/0003-4819-110-9-685","article-title":"Methylprednisolone therapy in patients with severe alcoholic hepatitis. 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