{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:39:05Z","timestamp":1789141145250,"version":"build-2803163510"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biom\u00e9decine database, the present study aimed to quantify the risk of solid organ de novo malignancies (excluding nonmelanoma skin cancers) after LT. The incidence of de novo malignancies among all LT patients between 1993 and 2012 was compared with that of the French population, standardized on age, sex, and calendar period (standardized incidence ratio; SIR). Among the 11,226 LT patients included in the study, 1200 de novo malignancies were diagnosed (10.7%). The risk of death was approximately 2 times higher in patients with de novo malignancy (48.8% versus 24.3%). The SIR for all de novo solid organ malignancies was 2.20 (95% confidence interval [CI], 2.08\u20102.33). The risk was higher in men (SIR = 2.23; 95% CI, 2.09\u20102.38) and in patients transplanted for alcoholic liver disease (ALD; SIR = 2.89; 95% CI, 2.68\u20103.11). The cancers with the highest excess risk were laryngeal (SIR = 7.57; 95% CI, 5.97\u20109.48), esophageal (SIR = 4.76; 95% CI, 3.56\u20106.24), lung (SIR = 2.56; 95% CI, 2.21\u20102.95), and lip\u2010mouth\u2010pharynx (SIR = 2.20; 95% CI, 1.72\u20102.77). In conclusion, LT recipients have an increased risk of de novo solid organ malignancies, and this is strongly related to ALD as a primary indication for LT.<\/jats:p>","DOI":"10.1002\/lt.25310","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T07:48:28Z","timestamp":1531986508000},"page":"1425-1436","source":"Crossref","is-referenced-by-count":63,"title":["Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients"],"prefix":"10.1097","volume":"24","author":[{"given":"Olivier","family":"S\u00e9r\u00e9e","sequence":"first","affiliation":[{"name":"R\u00e9seau R\u00e9gional de Canc\u00e9rologie OncoBasseNormandie,H\u00e9rouville Saint Clair,France"},{"name":"Unit\u00e9 de Formation et de Recherche Sant\u00e9 Caen France, U1086 INSERM\u2010 \u201cANTICIPE\u201d,Caen,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Altieri","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche Sant\u00e9 Caen France, U1086 INSERM\u2010 \u201cANTICIPE\u201d,Caen,France"},{"name":"Service d\u2019H\u00e9pato\u2010Gastroent\u00e9rologie, Nutrition et Oncologie Digestive, H\u00f4pital C\u00f4te de Nacre,Caen,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Guillaume","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche Sant\u00e9 Caen France, U1086 INSERM\u2010 \u201cANTICIPE\u201d,Caen,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"De Mil","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche Sant\u00e9 Caen France, U1086 INSERM\u2010 \u201cANTICIPE\u201d,Caen,France"},{"name":"Unit\u00e9 d\u2019\u00c9valuation et de 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U850,Limoges,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Debray","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019H\u00e9patologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP\u2010HP,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Hery","sequence":"additional","affiliation":[{"name":"Service de Chirurgie P\u00e9diatrique et Transplantation, H\u00f4pital Timone Enfants, AP\u2010HM,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Dharancy","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9patologie, H\u00f4pital Claude Huriez,CHRU Lille,Lille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Durand","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9patologie et Transplantation H\u00e9patique,Universit\u00e9 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Nice\u2010Sophia\u2010Antipolis,Nice,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Hardwigsen","sequence":"additional","affiliation":[{"name":"Service de Chirurgie G\u00e9n\u00e9rale et Transplantation H\u00e9patique,AP\u2010HM H\u00f4pital La Timone,Marseille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Houssel\u2010Debry","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9patologie et Transplantation H\u00e9patique,H\u00f4pital Universitaire de Pontchaillou,Rennes,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Jacquemin","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9patologie et Transplantation H\u00e9patique P\u00e9diatrique, H\u00f4pital Kremlin Bic\u00eatre, AP\u2010HP,Universit\u00e9 Paris Sud Orsay, INSERM UMR 1174, DHU H\u00e9patinov, Le Kremlin\u2010Bic\u00eatre,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassim","family":"Kamar","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019Organes,Centre Hospitalier Universitaire Rangueil,Toulouse,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Latournerie","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato\u2010Gastroent\u00e9rologie et Oncologie Digestive, INSERM EPICAD LNC, Unit\u00e9s Mixte de Recherche 1231,Centre Hospitalier Universitaire Dijon, Universit\u00e9 de Bourgogne\u2010Franche Comt\u00e9,Dijon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Lebray","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9patologie et Transplantation H\u00e9patique, H\u00f4pital de la Piti\u00e9 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Bordeaux,Bordeaux,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges\u2010Philippe","family":"Pageaux","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019H\u00e9patologie et Transplantation H\u00e9patique,Centre Hospitalier Universitaire Saint Eloi,Montpellier,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Radenne","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato\u2010Gastroent\u00e9rologie,H\u00f4pital de la Croix Rousse,Hospices Civils de Lyon, Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faouzi","family":"Saliba","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire, H\u00f4pital Paul Brousse, AP\u2010HP,INSERM Unit\u00e9 1193,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Samuel","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire, H\u00f4pital Paul Brousse, AP\u2010HP,INSERM Unit\u00e9 1193,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Vanlemmens","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9patologie et Soins Intensifs Digestifs,H\u00f4pital Jean Minjoz,Besan\u00e7on,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Lorraine","family":"Woehl\u2010Jaegle","sequence":"additional","affiliation":[{"name":"Service de Chirurgie H\u00e9pato\u2010Bilio\u2010Pancr\u00e9atique et Transplantation H\u00e9patique,CHRU Hautepierre,Strasbourg,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Launoy","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche Sant\u00e9 Caen France, U1086 INSERM\u2010 \u201cANTICIPE\u201d,Caen,France"},{"name":"Unit\u00e9 d\u2019\u00c9valuation et de Recherche en Epid\u00e9miologie, H\u00f4pital C\u00f4te de Nacre,Caen,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Dumortier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Transplantation H\u00e9patique, et Universit\u00e9 Claude Bernard Lyon 1, H\u00f4pital Edouard Herriot,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"lt25310-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.lts.2003.09.018","article-title":"Evolution of liver transplantation in Europe: report of the European Liver Transplant Registry","volume":"9","year":"2003","journal-title":"Liver Transpl"},{"issue":"suppl 1","key":"lt25310-bib-0003-20240115","first-page":"S109","article-title":"De novo malignancies after liver transplantation: a major cause of late death","volume":"7","year":"2001","journal-title":"Liver 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