{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:38:23Z","timestamp":1789144703796,"version":"build-2803163510"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Identifying patients at high risk for acute kidney injury (AKI) during hospitalization among patients admitted with severe alcoholic hepatitis (AH) is an unmet clinical need. We performed a multicentric prospective cohort study using data from 4 different cohorts on well\u2010characterized patients hospitalized with severe AH. Data collected on 773 AH patients from 4 cohorts across the globe were randomly split into test (n = 390) and validation (n = 383) cohorts. We found that 32% of the patients developed inpatient AKI in the test cohort. Approximately 60% of patients met criteria for systemic inflammatory response syndrome (SIRS) at admission. Hepatic encephalopathy, SIRS, and Model for End\u2010Stage Liver Disease score at admission predicted inpatient AKI with odds ratios of 3.86, 2.24, and 1.14, respectively. The AKI risk score developed using these predictors stratified risk of inpatient AKI to low (score &lt;3), moderate (3\u20104), and high (&gt;4). These findings were replicated in the validation cohort. In the whole study cohort, patients with AKI had a lower 90\u2010day survival (53% versus 77%; <jats:italic toggle=\"yes\">P <\/jats:italic>&lt; 0.001). Those with AKI risk score of &gt;4 had significantly lower 90\u2010day survival as compared with those with risk scores between 3 and 4 and &lt;3 (47% versus 68% versus 88%; <jats:italic toggle=\"yes\">P <\/jats:italic>&lt; 0.001). In conclusion, AKI occurs frequently in AH patients and negatively impacts short\u2010term mortality. The AKI risk score is useful in identifying patients at high risk for inpatient AKI and may be useful for developing new therapeutic strategies to prevent AKI in patients with AH.<\/jats:p>","DOI":"10.1002\/lt.25328","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T05:04:53Z","timestamp":1535605493000},"page":"1655-1664","source":"Crossref","is-referenced-by-count":56,"title":["A Validated Score Predicts Acute Kidney Injury and Survival in Patients With Alcoholic Hepatitis"],"prefix":"10.1097","volume":"24","author":[{"given":"Ravi","family":"Sujan","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham,Birmingham,AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Cruz\u2010Lemini","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Neurodesarrollo,Instituto de Neurobiolog\u00eda,Universidad Nacional Aut\u00f3noma de M\u00e9xico,Campus Juriquilla,Queretaro,Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Altamirano","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Department,Vall d\u2019Hebr\u00f3n University Hospital, Vall d\u2019Hebr\u00f3n Institut de Recerca,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Simonetto","sequence":"additional","affiliation":[{"name":"Mayo Clinic,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhi","family":"Maiwall","sequence":"additional","affiliation":[{"name":"Institute of Liver and Biliary Sciences,New Delhi,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Page","family":"Axley","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham,Birmingham,AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Richardson","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham,Birmingham,AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Desai","sequence":"additional","affiliation":[{"name":"Mayo Clinic,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Cabezas","sequence":"additional","affiliation":[{"name":"Pittsburgh Liver Research Center,University of Pittsburgh Medical Center,Pittsburgh,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Vargas","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Department,Vall d\u2019Hebr\u00f3n University Hospital, Vall d\u2019Hebr\u00f3n Institut de Recerca,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Kamath","sequence":"additional","affiliation":[{"name":"Mayo Clinic,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Mayo Clinic,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv K.","family":"Sarin","sequence":"additional","affiliation":[{"name":"Institute of Liver and Biliary Sciences,New Delhi,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Bataller","sequence":"additional","affiliation":[{"name":"Pittsburgh Liver Research Center,University of Pittsburgh Medical Center,Pittsburgh,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani K.","family":"Singal","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham,Birmingham,AL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"lt25328-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/cld.168","article-title":"Recent trends in the epidemiology of alcoholic liver disease","volume":"2","year":"2013","journal-title":"Clin Liver Dis"},{"key":"lt25328-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic hepatitis","volume":"360","year":"2009","journal-title":"N Engl J Med"},{"key":"lt25328-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cgh.2013.06.013","article-title":"Alcoholic hepatitis: current challenges and future directions","volume":"12","year":"2014","journal-title":"Clin Gastroenterol 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