{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:22:38Z","timestamp":1779924158732,"version":"3.53.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Patients having received a liver transplantation (LT) for alcoholic liver disease (ALD) have a high risk of de novo malignancies, especially in the upper aerodigestive tract and lungs due to their smoking and alcohol history. The aim of this retrospective study was to compare a group of patients transplanted for ALD who continue to smoke and who were included in an intensive screening program for tobacco\u2010related cancers implemented at the Grenoble University Hospital and a group of similar patients followed according to usual practice (chest computed tomography [CT] scan every 5 years) at the Edouard Herriot Hospital in Lyon. The intensive screening program consisted of an annual checkup, including a clinical examination by an otorhinolaryngologist, a chest CT scan, and an upper digestive endoscopy. A total of 147 patients were included: 71 patients in Grenoble and 76 patients in Lyon. The cumulative incidence of a first tobacco\u2010related cancer was 12.3% at 3 years, 20.6% at 5 years, 42.6% at 10 years, and 64.0% at 15 years. A curative treatment was possible in 80.0% of the patients in Grenoble versus 57.9% in Lyon (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.068). The rates of curative treatment were 63.6% versus 26.3% (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.062) for lung cancers, 100.0% versus 87.5% (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.498) for lip\u2010mouth\u2010pharynx and larynx cancers, and 66.7% versus 100.0% (<jats:italic toggle=\"yes\">P<\/jats:italic> = 1) for esophageal cancers, respectively. In addition, for lung cancers, regardless of study group, 68.7% received a curative treatment when the diagnosis was made by CT scan screening versus 14.3% when it was made because of symptoms (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.008). In conclusion, our study strongly confirms the high rate of tobacco\u2010related de novo malignancies in LT patients for ALD and suggests that the screening of lung cancer by annual chest CT scan could significantly increase the rate of curative treatment.<\/jats:p>","DOI":"10.1002\/lt.25336","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T11:09:28Z","timestamp":1536750568000},"page":"1690-1698","source":"Crossref","is-referenced-by-count":22,"title":["De Novo Malignancies Screening After Liver Transplantation for Alcoholic Liver Disease: A Comparative Opportunistic Study"],"prefix":"10.1097","volume":"24","author":[{"given":"Laurence","family":"Renaud","sequence":"first","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010No\u00eblle","family":"Hilleret","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Thimonier","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration des Sp\u00e9cialit\u00e9s Digestives,H\u00f4pital Edouard Herriot, Hospices Civils de Lyon,Lyon,France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Guillaud","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration des Sp\u00e9cialit\u00e9s Digestives,H\u00f4pital Edouard Herriot, Hospices Civils de Lyon,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Arbib","sequence":"additional","affiliation":[{"name":"Service de Pneumologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Service de Radiologie et Imagerie M\u00e9dicale,H\u00f4pital A. Michallon, Centre Hospitalier Universitaire de Grenoble,La Tronche,France"},{"name":"Universit\u00e9 Grenoble\u2010Alpes,Grenoble,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Service de Radiologie et Imagerie M\u00e9dicale,H\u00f4pital A. Michallon, Centre Hospitalier Universitaire de Grenoble,La Tronche,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Chambon\u2010Augoyard","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration des Sp\u00e9cialit\u00e9s Digestives,H\u00f4pital Edouard Herriot, Hospices Civils de Lyon,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domitille","family":"Erard\u2010Poinsot","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration des Sp\u00e9cialit\u00e9s Digestives,H\u00f4pital Edouard Herriot, Hospices Civils de Lyon,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Decaens","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie"},{"name":"Universit\u00e9 Grenoble\u2010Alpes,Grenoble,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Boillot","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration des Sp\u00e9cialit\u00e9s Digestives,H\u00f4pital Edouard Herriot, Hospices Civils de Lyon,Lyon,France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Leroy","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie"},{"name":"Universit\u00e9 Grenoble\u2010Alpes,Grenoble,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Dumortier","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration des Sp\u00e9cialit\u00e9s Digestives,H\u00f4pital Edouard Herriot, Hospices Civils de Lyon,Lyon,France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"lt25336-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1600-6143.2009.02869.x","article-title":"for ELITA, ELTR Liver Transplant Centers. Liver transplantation for alcoholic liver disease in Europe: a study from the ELTR (European Liver Transplant Registry)","volume":"10","year":"2010","journal-title":"Am J Transplant"},{"key":"lt25336-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1053\/j.gastro.2009.08.070","article-title":"Long\u2010term probability of and mortality from de novo malignancy after liver transplantation","volume":"137","year":"2009","journal-title":"Gastroenterology"},{"key":"lt25336-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/j.1600-6143.2010.03126.x","article-title":"Evolution of causes and risk factors for mortality post\u2010liver transplant: results of the NIDDK long\u2010term follow\u2010up study","volume":"10","year":"2010","journal-title":"Am J Transplant"},{"key":"lt25336-bib-0004-20240115","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4254\/wjh.v7.i7.942","article-title":"Incidence, risk factors and outcome of de novo tumors in liver transplant recipients focusing on alcoholic cirrhosis","volume":"7","year":"2015","journal-title":"World J Hepatol"},{"key":"lt25336-bib-0005-20240115","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/j.1572-0241.2007.01079.x","article-title":"Negative impact of de novo malignancies rather than alcohol relapse on survival after liver transplantation for alcoholic cirrhosis: a retrospective analysis of 305 patients in a single center","volume":"102","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"lt25336-bib-0006-20240115","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/lt.22247","article-title":"Risk factors of lung, head and neck, esophageal, and kidney and urinary tract carcinomas after liver transplantation: the effect of smoking withdrawal","volume":"17","year":"2011","journal-title":"Liver Transpl"},{"key":"lt25336-bib-0007-20240115","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/lt.23531","article-title":"Burden of de novo malignancy in the liver transplant recipient","volume":"18","year":"2012","journal-title":"Liver Transpl"},{"key":"lt25336-bib-0008-20240115","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/lt.21722","article-title":"Smoking behavior in liver transplant recipients","volume":"15","year":"2009","journal-title":"Liver Transpl"},{"key":"lt25336-bib-0009-20240115","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/00007890-199902150-00014","article-title":"Increased incidence of oropharyngeal squamous cell carcinomas after liver transplantation for alcoholic cirrhosis","volume":"67","year":"1999","journal-title":"Transplantation"},{"key":"lt25336-bib-0010-20240115","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/00007890-200011150-00012","article-title":"Long\u2010term follow\u2010up after liver transplantation for alcoholic liver disease under tacrolimus","volume":"70","year":"2000","journal-title":"Transplantation"},{"key":"lt25336-bib-0011-20240115","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1016\/S0041-1345(03)00641-9","article-title":"Upper aerodigestive tract and lung tumors after liver transplantation","volume":"35","year":"2003","journal-title":"Transplant Proc"},{"key":"lt25336-bib-0012-20240115","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/ctr.12430","article-title":"Conversion to everolimus dramatically improves the prognosis of de novo malignancies after liver transplantation for alcoholic liver disease","volume":"28","year":"2014","journal-title":"Clin Transplant"},{"key":"lt25336-bib-0013-20240115","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2165\/00003495-200767080-00006","article-title":"Immunosuppressive therapy and malignancy in organ transplant recipients: a systematic review","volume":"67","year":"2007","journal-title":"Drugs"},{"issue":"suppl 2","key":"lt25336-bib-0014-20240115","first-page":"S90","article-title":"De novo malignancies following liver transplantation: impact and recommendations","volume":"15","year":"2009","journal-title":"Liver Transpl"},{"key":"lt25336-bib-0015-20240115","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1111\/j.1600-6143.2009.02766.x","article-title":"Extensive surveillance promotes early diagnosis and improved survival of de novo malignancies in liver transplant recipients","volume":"9","year":"2009","journal-title":"Am J Transplant"},{"key":"lt25336-bib-0016-20240115","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1440-1746.2011.06981.x","article-title":"Screening of de novo tumors after liver transplantation","volume":"27","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"lt25336-bib-0017-20240115","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1399-0012.2008.00927.x","article-title":"Usefulness of a program of neoplasia surveillance in liver transplantation. a preliminary report","volume":"23","year":"2009","journal-title":"Clin Transplant"},{"key":"lt25336-bib-0018-20240115","doi-asserted-by":"crossref","first-page":"587","DOI":"10.12659\/AOT.884021","article-title":"Lung cancer screening with low\u2010radiation dose computed tomography after liver transplantation","volume":"18","year":"2013","journal-title":"Ann Transplant"},{"key":"lt25336-bib-0019-20240115","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/lt.23722","article-title":"Incidence and long\u2010term risk of de novo malignancies after liver transplantation with implications for prevention and detection","volume":"19","year":"2013","journal-title":"Liver Transpl"},{"key":"lt25336-bib-0020-20240115","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"for National Lung Screening Trial Research Team. Reduced lung\u2010cancer mortality with low\u2010dose computed tomographic screening","volume":"365","year":"2011","journal-title":"N Engl J Med"},{"key":"lt25336-bib-0021-20240115","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.clinre.2018.04.011","article-title":"Immunosuppressive regimen and risk for de novo malignancies after liver transplantation for alcoholic liver disease","volume":"42","year":"2018","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"lt25336-bib-0022-20240115","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/lt.21058","article-title":"De novo esophageal neoplasia after liver transplantation","volume":"13","year":"2007","journal-title":"Liver Transpl"},{"key":"lt25336-bib-0023-20240115","article-title":"Integrating smoking cessation care in alcohol and other drug treatment settings using an organizational change intervention: a systematic review","year":"2018","journal-title":"Addiction"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.25336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201812000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T01:13:45Z","timestamp":1705281225000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201812000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.25336","relation":{},"ISSN":["1527-6465","1527-6473"],"issn-type":[{"value":"1527-6465","type":"print"},{"value":"1527-6473","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}