{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T08:28:10Z","timestamp":1721291290711},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>We aimed to evaluate the association between intraoperative pulmonary vascular resistance (PVR) and clinical outcome of liver transplantation (LT). Cardiovascular involvement of end\u2010stage liver disease is relatively common, and hemodynamic instability during LT can be fatal to recipients. However, the clinical impact of intraoperative PVR in LT remains undetermined. A total of 363 adult recipients with intraoperative right heart catheterization from January 2011 to May 2016 were analyzed. Patients were divided into 2 groups according to PVR. Two separate analyses were performed according to the time point of measurement: at the beginning and at the end of LT. The primary outcome was all\u2010cause death or graft failure during the follow\u2010up period. Increased PVR was observed in 11.8% (43\/363) of recipients at the beginning and 12.7% (46\/363) of recipients at the end of LT. PVR at the beginning of LT had no significant effect on the rate of death or graft failure in the multivariate analysis (hazard ratio [HR], 1.24; 95% confidence interval [CI], 0.64\u20102.38; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.52). In contrast, PVR at the end of LT was significantly associated with death or graft failure during the overall follow\u2010up period (HR, 2.00; 95% CI, 1.13\u20103.54; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.02). In conclusion, PVR at the end of LT, rather than the beginning, is associated with clinical outcome. Larger trials are needed to support this finding.<\/jats:p>","DOI":"10.1002\/lt.25341","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T01:59:29Z","timestamp":1537581569000},"page":"1680-1689","source":"Crossref","is-referenced-by-count":3,"title":["Predictive Value of Intraoperative Pulmonary Vascular Resistance in Liver Transplantation"],"prefix":"10.1097","volume":"24","author":[{"given":"Jungchan","family":"Park","sequence":"first","affiliation":[{"name":"Departments of Anesthesiology and Pain Medicine,Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul,South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart, Stroke and Vascular Institute,Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul,South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeayoun","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and Pain Medicine,Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul,South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and Pain Medicine,Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul,South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine,Dongtan Sacred Heart Hospital, Hallym University School of Medicine,Seoul,South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyu\u2010Seong","family":"Choi","sequence":"additional","affiliation":[{"name":"Surgery,Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul,South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk\u2010Koo","family":"Lee","sequence":"additional","affiliation":[{"name":"Surgery,Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul,South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaab Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine,Dongtan Sacred Heart Hospital, Hallym University School of Medicine,Seoul,South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"lt25341-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/hep.510240226","article-title":"Cirrhotic cardiomyopathy: getting to the heart of the matter","volume":"24","year":"1996","journal-title":"Hepatology"},{"key":"lt25341-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/14017430802691528","article-title":"Cardiac and systemic haemodynamic complications of liver cirrhosis","volume":"43","year":"2009","journal-title":"Scand Cardiovasc J"},{"issue":"suppl 1","key":"lt25341-bib-0003-20240115","first-page":"45","article-title":"Updated clinical classification of pulmonary hypertension [in Turkish]","volume":"42","year":"2014","journal-title":"Turk Kardiyol Dern Ars"},{"key":"lt25341-bib-0004-20240115","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.00008611","article-title":"Pulmonary vascular resistances during exercise in normal subjects: a systematic review","volume":"39","year":"2012","journal-title":"Eur Respir J"},{"key":"lt25341-bib-0005-20240115","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/jlts.2000.6356","article-title":"Pulmonary hemodynamics and perioperative cardiopulmonary\u2010related mortality in patients with portopulmonary hypertension undergoing liver transplantation","volume":"6","year":"2000","journal-title":"Liver Transpl"},{"key":"lt25341-bib-0006-20240115","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1136\/thx.2008.112847","article-title":"Pulmonary vascular resistance predicts early mortality in patients with diffuse fibrotic lung disease and suspected pulmonary hypertension","volume":"64","year":"2009","journal-title":"Thorax"},{"key":"lt25341-bib-0007-20240115","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.amjcard.2007.11.010","article-title":"Usefulness of noninvasive estimate of pulmonary vascular resistance to predict mortality, heart failure, and adverse cardiovascular events in patients with stable coronary artery disease (from the Heart and Soul Study)","volume":"101","year":"2008","journal-title":"Am J Cardiol"},{"key":"lt25341-bib-0008-20240115","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","year":"2004","journal-title":"Ann Surg"},{"key":"lt25341-bib-0009-20240115","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/lt.24768","article-title":"Cirrhotic cardiomyopathy: implications for liver transplantation","volume":"23","year":"2017","journal-title":"Liver Transpl"},{"key":"lt25341-bib-0010-20240115","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.jacc.2016.12.037","article-title":"A test in context: E\/A and E\/e' to assess diastolic dysfunction and LV filling pressure","volume":"69","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"lt25341-bib-0011-20240115","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/lt.21300","article-title":"Incidence of severe ventricular arrhythmias during pulmonary artery catheterization in liver allograft recipients","volume":"13","year":"2007","journal-title":"Liver Transpl"},{"key":"lt25341-bib-0012-20240115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/TP.0000000000001517","article-title":"Frequency and outcomes of patients with increased mean pulmonary artery pressure at the time of liver transplantation","volume":"101","year":"2017","journal-title":"Transplantation"},{"key":"lt25341-bib-0014-20240115","doi-asserted-by":"crossref","first-page":"e0177838","DOI":"10.1371\/journal.pone.0177838","article-title":"Preoperative cardiac troponin level is associated with all\u2010cause mortality of liver transplantation recipients","volume":"12","year":"2017","journal-title":"PLoS One"},{"key":"lt25341-bib-0015-20240115","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jacc.2011.03.026","article-title":"Cardiovascular risk assessment of the liver transplant candidate","volume":"58","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"lt25341-bib-0016-20240115","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jhep.2010.02.023","article-title":"Cirrhotic cardiomyopathy","volume":"53","year":"2010","journal-title":"J Hepatol"},{"key":"lt25341-bib-0017-20240115","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jacc.2009.12.075","article-title":"Cirrhotic cardiomyopathy","volume":"56","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"lt25341-bib-0018-20240115","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1378\/chest.107.1.218","article-title":"Hemodynamic correlates of outcome in patients undergoing orthotopic liver transplantation. evidence for early postoperative myocardial depression","volume":"107","year":"1995","journal-title":"Chest"},{"key":"lt25341-bib-0019-20240115","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/lt.21997","article-title":"Acute and long\u2010term effects of inhaled iloprost in portopulmonary hypertension","volume":"16","year":"2010","journal-title":"Liver Transpl"},{"key":"lt25341-bib-0020-20240115","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1665-2681(19)31832-0","article-title":"Portopulmonary hypertension: state of the art","volume":"7","year":"2008","journal-title":"Ann Hepatol"},{"key":"lt25341-bib-0021-20240115","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1111\/j.1600-6143.2006.01432.x","article-title":"Successful liver transplantation following medical management of portopulmonary hypertension: a single\u2010center series","volume":"6","year":"2006","journal-title":"Am J Transplant"},{"key":"lt25341-bib-0022-20240115","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1600-6143.2006.01701.x","article-title":"The impact of treatment of portopulmonary hypertension on survival following liver transplantation","volume":"7","year":"2007","journal-title":"Am J Transplant"},{"key":"lt25341-bib-0023-20240115","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1097\/TP.0000000000001370","article-title":"A novel predictor of posttransplant portal hypertension in adult\u2010to\u2010adult living donor liver transplantation: increased estimated spleen\/graft volume ratio","volume":"100","year":"2016","journal-title":"Transplantation"},{"key":"lt25341-bib-0024-20240115","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1097\/01.TP.0000063707.90525.10","article-title":"Changes in portal venous pressure in the early phase after living donor liver transplantation: pathogenesis and clinical implications","volume":"75","year":"2003","journal-title":"Transplantation"},{"key":"lt25341-bib-0025-20240115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/106002809502900309","article-title":"Proarrhythmic effects of intravenous vasopressors","volume":"29","year":"1995","journal-title":"Ann Pharmacother"},{"key":"lt25341-bib-0026-20240115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-2044.2002.02324.x","article-title":"The effect of phenylephrine and norepinephrine in patients with chronic pulmonary hypertension*","volume":"57","year":"2002","journal-title":"Anaesthesia"},{"key":"lt25341-bib-0027-20240115","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1111\/j.1476-5381.2011.01588.x","article-title":"Use of inotropes and vasopressor agents in critically ill patients","volume":"165","year":"2012","journal-title":"Br J Pharmacol"},{"key":"lt25341-bib-0028-20240115","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/bja\/aeh278","article-title":"Pulmonary vasodilator effects of norepinephrine during the development of chronic pulmonary hypertension in neonatal lambs","volume":"93","year":"2004","journal-title":"Br J Anaesth"},{"key":"lt25341-bib-0029-20240115","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/lt.20016","article-title":"Hepatopulmonary syndrome and portopulmonary hypertension: a report of the multicenter liver transplant database","volume":"10","year":"2004","journal-title":"Liver Transpl"},{"key":"lt25341-bib-0030-20240115","doi-asserted-by":"crossref","first-page":"11131","DOI":"10.3748\/wjg.v20.i32.11131","article-title":"Hepatic hemodynamic changes during liver transplantation: a review","volume":"20","year":"2014","journal-title":"World J Gastroenterol"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.25341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-201812000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T01:13:54Z","timestamp":1705281234000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-201812000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.25341","relation":{},"ISSN":["1527-6465","1527-6473"],"issn-type":[{"value":"1527-6465","type":"print"},{"value":"1527-6473","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}