{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:47:41Z","timestamp":1791848861791,"version":"4.3.4"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P3 DK026743"],"award-info":[{"award-number":["P3 DK026743"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Alcohol\u2010associated liver disease (ALD) is the most common indication for liver transplantation (LT) in the United States and Europe. A 6\u2010month alcohol abstinence period has been required by many transplant programs prior to listing, which may influence wait\u2010list (WL) outcomes. Therefore, we examined WL events in patients with ALD versus non\u2010ALD with a special interest in whether these outcomes differed by sex. All US adults listed for LT from January 2002 to December 2016 were eligible except status 1 patients, Model for End\u2010Stage Liver Disease exceptions, retransplants and those with acute alcoholic hepatitis. The outcomes of interest were cumulative WL death or being too sick and WL removal for improvement within 2\u00a0years of listing. Competing risk regression models were used to evaluate recipient factors associated with the outcomes. Among the 83,348 eligible WL patients, 23% had ALD. Unadjusted cumulative WL removal within 2\u00a0years was 19.0% for ALD versus 21.1% for non\u2010ALD (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001). In fully adjusted models, ALD was associated with a significantly lower risk of WL removal for death or being too sick (subhazard ratio [SHR], 0.84; 95% confidence interval [CI], 0.81\u20100.87; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001) and a higher risk of removal for improvement (SHR, 2.91; 95% CI, 2.35\u20103.61; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001) versus non\u2010ALD patients. After adjusting for potential confounders, women with ALD had a higher risk of removal for death or being too sick (SHR, 1.09; 95% CI, 1.00\u20101.08; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001) and a higher chance for improvement (SHR, 2.91; 95% CI, 2.35\u20103.61; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001) than men with ALD. In conclusion, WL candidates with ALD have more favorable WL outcomes than non\u2010ALD patients with a 16% lower risk of removal for deterioration and 191% higher risk of removal for improvement. This result likely reflects the benefits of alcohol abstinence, but it suggests that listing criteria for ALD may be too restrictive, with patients who might derive benefit from LT not being listed.<\/jats:p>","DOI":"10.1002\/lt.25485","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T21:11:34Z","timestamp":1557263494000},"page":"1310-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Superior Wait\u2010List Outcomes in Patients with Alcohol\u2010Associated Liver Disease Compared With Other Indications for Liver Transplantation"],"prefix":"10.1097","volume":"25","author":[{"given":"Jeanne\u2010Marie","family":"Giard","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al,Montr\u00e9al,Qu\u00e9bec,Canada"},{"name":"Department of Surgery,University of California, San Francisco,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Dodge","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al,Montr\u00e9al,Qu\u00e9bec,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4143-1950","authenticated-orcid":false,"given":"Norah A.","family":"Terrault","sequence":"additional","affiliation":[{"name":"University of Southern California,Los Angeles,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"issue":"suppl 1","key":"lt25485-bib-0001-20240115","first-page":"172","article-title":"OPTN\/SRTR 2016 annual data report: liver","volume":"18","year":"2018","journal-title":"Am J Transplant"},{"key":"lt25485-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jhep.2018.06.010","article-title":"Impact of DAAs on liver transplantation: major effects on the evolution of indications and results. an ELITA study based on the ELTR registry","volume":"69","year":"2018","journal-title":"J Hepatol"},{"key":"lt25485-bib-0004-20240115","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1056\/NEJMoa1105703","article-title":"Early liver transplantation for severe alcoholic hepatitis","volume":"365","year":"2011","journal-title":"N Engl J Med"},{"key":"lt25485-bib-0005-20240115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/SLA.0000000000001831","article-title":"Three\u2010year results of a pilot program in early liver transplantation for severe alcoholic hepatitis","volume":"265","year":"2017","journal-title":"Ann Surg"},{"key":"lt25485-bib-0006-20240115","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1053\/j.gastro.2018.04.009","article-title":"Outcomes of early liver transplantation for patients with severe alcoholic hepatitis","volume":"155","year":"2018","journal-title":"Gastroenterology"},{"key":"lt25485-bib-0007-20240115","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/hep.1840110223","article-title":"Should patients with end\u2010stage alcoholic liver disease have a new liver?","volume":"11","year":"1990","journal-title":"Hepatology"},{"key":"lt25485-bib-0008-20240115","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1111\/ajt.13176","article-title":"Early liver transplantation for patients with acute alcoholic hepatitis: public views and the effects on organ donation","volume":"15","year":"2015","journal-title":"Am J Transplant"},{"key":"lt25485-bib-0009-20240115","first-page":"1356","article-title":"Orthotopic liver transplantation for alcoholic liver disease: rates of survival, complications and relapse","volume":"44","year":"1997","journal-title":"Hepatogastroenterology"},{"key":"lt25485-bib-0010-20240115","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/00007890-199409150-00006","article-title":"Efficacy of liver transplantation for alcoholic cirrhosis with respect to recidivism and compliance","volume":"58","year":"1994","journal-title":"Transplantation"},{"key":"lt25485-bib-0011-20240115","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/00007890-200108270-00010","article-title":"Liver transplantation for alcoholic cirrhosis: long term follow\u2010up and impact of disease recurrence","volume":"72","year":"2001","journal-title":"Transplantation"},{"key":"lt25485-bib-0012-20240115","article-title":"National trends and long\u2010term outcomes of liver transplant for alcohol\u2010associated liver disease in the United States","year":"2019","journal-title":"JAMA Intern Med"},{"key":"lt25485-bib-0013-20240115","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1600-6143.2009.02869.x","article-title":"Liver transplantation for alcoholic liver disease in Europe: a study from the ELTR (European Liver Transplant Registry)","volume":"10","year":"2010","journal-title":"Am J Transplant"},{"key":"lt25485-bib-0014-20240115","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/lt.500030305","article-title":"Liver transplantation for alcoholic liver disease: a survey of transplantation programs in the United States","volume":"3","year":"1997","journal-title":"Liver Transpl Surg"},{"key":"lt25485-bib-0015-20240115","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/lt.25285","article-title":"Survey of liver transplantation practices for severe acute alcoholic hepatitis","volume":"24","year":"2018","journal-title":"Liver Transpl"},{"key":"lt25485-bib-0016-20240115","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1056\/NEJMe1110864","article-title":"Transplantation for alcoholic hepatitis\u2013time to rethink the 6\u2010month \u201crule.\u201d","volume":"365","year":"2011","journal-title":"N Engl J Med"},{"key":"lt25485-bib-0017-20240115","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1572-0241.2007.01691.x","article-title":"A critical review of candidacy for orthotopic liver transplantation in alcoholic liver disease","volume":"103","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"lt25485-bib-0018-20240115","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/lt.21278","article-title":"Meta\u2010analysis of risk for relapse to substance use after transplantation of the liver or other solid organs","volume":"14","year":"2008","journal-title":"Liver Transpl"},{"key":"lt25485-bib-0019-20240115","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/j.1600-6143.2006.01321.x","article-title":"Waiting list removal rates among patients with chronic and malignant liver diseases","volume":"6","year":"2006","journal-title":"Am J Transplant"},{"key":"lt25485-bib-0020-20240115","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/hep.23007","article-title":"Effect of alcoholic liver disease and hepatitis C infection on waiting list and posttransplant mortality and transplant survival benefit","volume":"50","year":"2009","journal-title":"Hepatology"},{"key":"lt25485-bib-0021-20240115","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/hep.21025","article-title":"Deaths on the liver transplant waiting list: an analysis of competing risks","volume":"43","year":"2006","journal-title":"Hepatology"},{"key":"lt25485-bib-0022-20240115","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jhep.2014.11.023","article-title":"Outcomes in liver transplantation: does sex matter?","volume":"62","year":"2015","journal-title":"J Hepatol"},{"key":"lt25485-bib-0023-20240115","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1111\/j.1600-6143.2010.03326.x","article-title":"Height contributes to the gender difference in wait\u2010list mortality under the MELD\u2010based liver allocation system","volume":"10","year":"2010","journal-title":"Am J Transplant"},{"key":"lt25485-bib-0024-20240115","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1097\/TP.0000000000002196","article-title":"Reduced access to liver transplantation in women: role of height, MELD exception scores, and renal function underestimation","volume":"102","year":"2018","journal-title":"Transplantation"},{"key":"lt25485-bib-0025-20240115","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1001\/jamapsychiatry.2017.2161","article-title":"Prevalence of 12\u2010month alcohol use, high\u2010risk drinking, and DSM\u2010IV alcohol use disorder in the United States, 2001\u20132002 to 2012\u20132013: results from the national epidemiologic survey on alcohol and related conditions","volume":"74","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"lt25485-bib-0026-20240115","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0016-5085(87)90861-4","article-title":"Prognosis of alcoholic cirrhosis in the presence and absence of alcoholic hepatitis","volume":"92","year":"1987","journal-title":"Gastroenterology"},{"key":"lt25485-bib-0027-20240115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/gut.2010.224097","article-title":"Corticosteroids improve short\u2010term survival in patients with severe alcoholic hepatitis: meta\u2010analysis of individual patient data","volume":"60","year":"2011","journal-title":"Gut"},{"issue":"suppl 1","key":"lt25485-bib-0028-20240115","first-page":"174","article-title":"OPTN\/SRTR 2015 annual data report: liver","volume":"17","year":"2017","journal-title":"Am J Transplant"},{"key":"lt25485-bib-0029-20240115","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1111\/acer.12887","article-title":"Clinical impact of alcohol\u2010related cirrhosis in the next decade: estimates based on current epidemiological trends in the United States","volume":"39","year":"2015","journal-title":"Alcohol Clin Exp Res"},{"key":"lt25485-bib-0031-20240115","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/tri.12756","article-title":"Good outcome after liver transplantation for ALD without a 6 months abstinence rule prior to transplantation including post\u2010transplant CDT monitoring for alcohol relapse assessment \u2010 a retrospective study","volume":"29","year":"2016","journal-title":"Transpl Int"},{"key":"lt25485-bib-0032-20240115","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1111\/acer.12117","article-title":"Liver transplantation in alcoholic patients: impact of an alcohol addiction unit within a liver transplant center","volume":"37","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"lt25485-bib-0033-20240115","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.gtc.2016.02.010","article-title":"Women with cirrhosis: prevalence, natural history, and management","volume":"45","year":"2016","journal-title":"Gastroenterol Clin North Am"},{"key":"lt25485-bib-0034-20240115","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.drugalcdep.2014.03.010","article-title":"Gender and race\/ethnicity differences for initiation of alcohol\u2010related service use among persons with alcohol dependence","volume":"140","year":"2014","journal-title":"Drug Alcohol Depend"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lt.25485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lt.25485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/lt.25485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T01:34:32Z","timestamp":1705282472000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/lt.25485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,24]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.25485","relation":{},"ISSN":["1527-6465","1527-6473"],"issn-type":[{"value":"1527-6465","type":"print"},{"value":"1527-6473","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,24]]},"assertion":[{"value":"2019-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}