{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:46:43Z","timestamp":1781617603012,"version":"3.54.5"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>Intracardiac thrombus (ICT) is an intraoperative complication with high mortality that occurs during orthotopic liver transplantation (OLT). Patients with end\u2010stage liver disease have compromised coagulation pathways, and when combined with stressors of surgery, thrombi can form. However, it is unknown which patients are most likely to develop ICT. We performed a retrospective cohort study of all OLT patients at our hospital from 2010 to 2017 to identify risk factors for ICT. An analysis was performed with conventional bivariate tests and logistic regression. The incidence of ICT during OLT was 4.2% (22\/528) with a 45.5% (10\/22) mortality. Patients who developed ICT had higher physiologic Model for End\u2010Stage Liver Disease scores at the time of transplant (25.1 versus 32.4; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.004), received grafts from donors with a higher body mass index (28.1 versus 32.2\u00a0kg\/m<jats:sup>2<\/jats:sup>; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.007), and had longer intraoperative warm ischemia times (53.1 versus 67.5 minutes; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.001). The odds of developing ICT were significantly lower after administration of intravenous (IV) heparin prior to inferior vena cava (IVC) clamping compared with no administration of heparin (odds ratio, 0.25; 95% confidence interval, 0.08\u20100.75; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.01). In conclusion, the incidence of ICT at our institution is higher than previously reported, which may be explained by our routine use of transesophageal echocardiography. Although many factors associated with ICT in this study are nonmodifiable, administration of IV heparin prior to IVC cross\u2010clamping is modifiable and was found to be protective. Further studies will be needed to confirm findings and ultimately aid in preventing these lethal events.<\/jats:p>","DOI":"10.1002\/lt.25498","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T14:21:20Z","timestamp":1558621280000},"page":"1682-1689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Risk Factors for Intracardiac Thrombus During Liver Transplantation"],"prefix":"10.1097","volume":"25","author":[{"given":"Molly K.","family":"Groose","sequence":"first","affiliation":[{"name":"Departments of Anesthesiology, Transplantation Division,University of Wisconsin Hospital,Madison,WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanna N.","family":"Aldred","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology, Transplantation Division,University of Wisconsin Hospital,Madison,WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Mezrich","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Transplantation Division,University of Wisconsin Hospital,Madison,WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L.","family":"Hammel","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology, Transplantation Division,University of Wisconsin Hospital,Madison,WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"lt25498-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.trre.2010.10.004","article-title":"Anesthesia care for liver transplantation","volume":"25","year":"2011","journal-title":"Transplant 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