{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:37:54Z","timestamp":1783121874695,"version":"3.54.6"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Renal dysfunction is common in liver transplantation (LT) candidates, but differentiating between reversible and irreversible renal injury can be difficult. Kidney biopsy might be helpful in differentiating reversible from irreversible renal injury, but it is associated with significant complications. We aimed to identify pre\u2010LT predictors of potentially reversible renal injury using histological information obtained on pre\u2010LT renal biopsy. Data on 128 LT candidates who underwent pre\u2010LT kidney biopsy were retrospectively collected and correlated with renal histological findings. Indications for kidney biopsy were iothalamate glomerular filtration rate (iGFR) \u226440\u00a0mL\/minute, proteinuria &gt;500\u00a0mg\/day, and\/or hematuria. According to the biopsy diagnosis, patients were grouped into the following categories: normal (n\u00a0=\u00a013); acute tubular necrosis (ATN; n\u00a0=\u00a025); membranoproliferative glomerulonephritis (n\u00a0=\u00a019); minimal histological changes (n\u00a0=\u00a024); and advanced interstitial fibrosis (IF) and glomerulosclerosis (GS) (n\u00a0=\u00a047). Compared with patients having advanced IF\/GS, patients with normal biopsies and those with ATN had lower systolic blood pressure (SBP) and diastolic blood pressure (DBP) and higher international normalized ratio and total bilirubin levels (&lt;0.05 for all). Both SBP and DBP directly correlated with the degree of IF and GS (<jats:italic toggle=\"yes\">R<\/jats:italic>\u00a0=\u00a00.3, <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0\u2264\u00a00.02 for all). SBP \u226490\u00a0mm\u00a0Hg was 100% sensitive and 98% specific in correlating with normal biopsies or ATN, whereas SBP \u2265140\u00a0mm\u00a0Hg was 22% sensitive and 90% specific in correlating with advanced IF\/GS. Model for End\u2010Stage Liver Disease score, serum creatinine, iGFR, urinary sodium excretion, and renal size did not correlate with biopsy diagnosis or degree of IF or GS. In conclusion, SBP at the time of LT evaluation correlates with renal histology, and it should be included along with other clinical and laboratory markers in the decision\u2010making process to list patients with renal dysfunction for LT alone versus simultaneous liver\u2010kidney transplantation.<\/jats:p>","DOI":"10.1002\/lt.25651","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T23:54:42Z","timestamp":1570665282000},"page":"1756-1767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Arterial Blood Pressure at Liver Transplant Evaluation Predicts Renal Histology in Candidates With Renal Dysfunction"],"prefix":"10.1097","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-0897","authenticated-orcid":false,"given":"Hani M.","family":"Wadei","sequence":"first","affiliation":[{"name":"Department of Transplant,Mayo Clinic,Jacksonville,FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Abader","sequence":"additional","affiliation":[{"name":"Department of Transplant,Mayo Clinic,Jacksonville,FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Alsaad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,Mayo Clinic,Jacksonville,FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher","family":"Croome","sequence":"additional","affiliation":[{"name":"Department of Transplant,Mayo Clinic,Jacksonville,FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherise","family":"Cortese","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology,Mayo Clinic,Jacksonville,FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xochiquetzal J.","family":"Geiger","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology,Mayo Clinic,Jacksonville,FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Khouzam","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology,Mayo Clinic,Jacksonville,FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin L.","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Transplant,Mayo Clinic,Jacksonville,FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Burcin","family":"Taner","sequence":"additional","affiliation":[{"name":"Department of Transplant,Mayo Clinic,Jacksonville,FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Keaveny","sequence":"additional","affiliation":[{"name":"Department of Transplant,Mayo Clinic,Jacksonville,FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"lt25651-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1053\/jhep.2002.33160","article-title":"Pretransplant renal function predicts survival in patients undergoing orthotopic liver transplantation","volume":"35","year":"2002","journal-title":"Hepatology"},{"key":"lt25651-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1111\/j.1600-6143.2006.01526.x","article-title":"Continued influence of preoperative renal function on outcome of orthotopic liver transplant (OLTX) in the 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