{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:59:40Z","timestamp":1794002380147,"version":"4.8.0"},"reference-count":77,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32 DK060414"],"award-info":[{"award-number":["T32 DK060414"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Acute\u2010on\u2010chronic liver failure (ACLF) is a feared complication that can develop at any stage of chronic liver disease. The incidence of ACLF is increasing, leading to a significant burden to both the affected individual and health care systems. To date, our understanding of ACLF suggests that it may be initiated by precipitants such as systemic infection, alcohol use, or viral hepatitis. The prevalence of these vary significantly by geography and underlying liver disease, and these precipitants have a varying impact on patient prognosis. Herein, we present a review of our current understanding of the precipitants of ACLF, including gaps in current data and opportunities for meaningful intervention and areas of future research.<\/jats:p>","DOI":"10.1002\/lt.25678","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T08:02:17Z","timestamp":1573545737000},"page":"283-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Precipitants of Acute\u2010on\u2010Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes"],"prefix":"10.1097","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2935-0245","authenticated-orcid":false,"given":"Giuseppe","family":"Cullaro","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Department of Medicine,University of California,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajani","family":"Sharma","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation,Department of Medicine,College of Physicians and Surgeons,Columbia University,New York,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-3881","authenticated-orcid":false,"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I,Goethe University of Frankfurt,Frankfurt,Germany"},{"name":"European Foundation for the Study of Chronic Liver Failure,Barcelona,Spain"},{"name":"Faculty of Health Sciences,University of Southern Denmark,Odense,Denmark"},{"name":"Institute for Bioengineering of Catalonia,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0764-7873","authenticated-orcid":false,"given":"Andr\u00e9s","family":"C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"GI\/Liver Unit,Institut de Malaties Digestives,Hospital Clinic,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Verna","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation,Department of Medicine,College of Physicians and Surgeons,Columbia University,New York,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"lt25678-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12072-008-9106-x","article-title":"Acute\u2010on\u2010chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)","volume":"3","year":"2009","journal-title":"Hepatol Int"},{"key":"lt25678-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"for CANONIC Study Investigators of the EASL\u2013CLIF Consortium. 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