{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:58Z","timestamp":1786978318212,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Liver transplantation (LT) for patients with propionic acidemia (PA) is an emerging therapeutic option. We present a retrospective review of patients with PA who underwent LT at a tertiary liver center between 1995 and 2015. A total of 14 children were identified (8 males) with median age at initial presentation of 3\u00a0days (range, 0\u201077\u00a0days). Pretransplant median protein restriction was 1\u00a0g\/kg\/day (range, 0.63\u20101.75\u00a0g\/kg\/day), 71% required supportive feeding, and 86% had developmental delay. Frequent metabolic decompensations (MDs) were the main indication for LT with a median age at transplantation of 2.4\u00a0years (range, 0.8\u20107.1\u00a0years). Only 1 graft was from a living donor, and 13 were from deceased donors (4 auxiliary). The 2\u2010year patient survival was 86%, and overall study and graft survival was 79% and 69%, respectively. Three patients died after LT: at 43\u00a0days (biliary peritonitis), 225\u00a0days (acute\u2010on\u2010chronic rejection with multiorgan failure), and 13.5\u00a0years (posttransplant lymphoproliferative disease). Plasma glycine and propionylcarnitine remained elevated but reduced after transplant. Of 11 survivors, 5 had at least 1 episode of acute cellular rejection, 2 sustained a metabolic stroke (with full recovery), and 3 developed mild cardiomyopathy after LT. All have liberalized protein intake, and 9 had no further MDs: median episodes before transplant, 4 (range, 1\u201030); and median episodes after transplant, 0 (range, 0\u20105). All survivors made some developmental progress after LT, and none worsened at a median follow\u2010up of 5.8\u00a0years (range, 2\u201023\u00a0years). LT in PA significantly reduces the frequency of MDs, can liberalize protein intake and improve quality of life, and should continue to be considered in selected cases.<\/jats:p>","DOI":"10.1002\/lt.25679","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T13:39:16Z","timestamp":1573565956000},"page":"419-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Liver Transplantation in Children With Propionic Acidemia: Medium\u2010Term Outcomes"],"prefix":"10.1097","volume":"26","author":[{"given":"Richard","family":"Curnock","sequence":"first","affiliation":[{"name":"Paediatric Inherited Metabolic Diseases,Evelina Children\u2019s Hospital,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel D.","family":"Heaton","sequence":"additional","affiliation":[{"name":"Liver Transplantation Surgery,Institute for Liver Studies,King\u2019s College Hospital,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Vilca\u2010Melendez","sequence":"additional","affiliation":[{"name":"Liver Transplantation Surgery,Institute for Liver Studies,King\u2019s College Hospital,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Paediatric Liver, Gastroenterology and Nutrition Centre,King\u2019s College Hospital,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedim","family":"Hadzic","sequence":"additional","affiliation":[{"name":"Paediatric Liver, Gastroenterology and Nutrition Centre,King\u2019s College Hospital,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshni","family":"Vara","sequence":"additional","affiliation":[{"name":"Paediatric Inherited Metabolic Diseases,Evelina Children\u2019s 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