{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:59:32Z","timestamp":1775476772039,"version":"3.50.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1E1A1A03070961"],"award-info":[{"award-number":["2017R1E1A1A03070961"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>The spatial variability of hepatic fat reduction in potential living liver donors with hepatic steatosis (HS) who undergo lifestyle modification has not been investigated. Here, we aimed to examine the intrasegmental and intersegmental variability of changes in liver attenuation on computed tomography (CT) in potential living liver donors with HS after diet modification and exercise. A total of 87 living liver donor candidates (30.5\u00a0\u00b1\u00a07.0\u00a0years; 74 males) with biopsy\u2010proven macrovesicular fat (MaF) \u226510% were included. All underwent diet modification and exercise to improve HS, baseline and follow\u2010up unenhanced CT scans, and liver biopsies. Attenuation and its variability (mean and standard deviation, respectively, in Hounsfield units) in segmental, lobar, superficial, deep, and whole areas of the liver were measured across 32 different regions of interest on both baseline and follow\u2010up CT. At baseline, the right lobe and superficial areas of liver showed significantly lower and more variable attenuation than left lobe and deep areas. Greater variability was noted in patients with more severe HS. Mean interval changes in liver attenuation and variability before and after diet modification and exercise were 13.7 (range, \u221210.6 to 46.2) and 4.7 (1.6\u201010.6), respectively. The mean interval change in liver attenuation was significantly higher in the right lobe than in the left (14.7 versus 12.7; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001), and in superficial areas than in deep areas (14.0 versus 13.4; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.02). Greater variability and larger interval changes in liver attenuation were noted in those who responded (\u226520% decrease in MaF) to diet modification and exercise than in those who did not. In conclusion, potential living liver donors with HS show significant intrasegmental and intersegmental variability in hepatic fat reduction on CT before and after diet modification and exercise.<\/jats:p>","DOI":"10.1002\/lt.25733","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T07:39:36Z","timestamp":1581752376000},"page":"487-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lifestyle Modification Leads to Spatially Variable Reduction in Hepatic Steatosis in Potential Living Liver Donors"],"prefix":"10.1097","volume":"26","author":[{"given":"Hyo Jung","family":"Park","sequence":"first","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology,University of Ulsan College of Medicine,Asan Medical Center,Seoul,Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6471-6727","authenticated-orcid":false,"given":"Kyoung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology,University of Ulsan College of Medicine,Asan Medical Center,Seoul,Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hyun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Liver Transplantation and Hepatobiliary Surgery,Department of Surgery,University of Ulsan College of Medicine,Asan Medical Center,Seoul,Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeongjin","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering,Soongsil University,Seoul,Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeyong","family":"Park","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering,Soongsil University,Seoul,Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heon\u2010Ju","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Radiology,Kangbuk Samsung Hospital,Sungkyunkwan University School of Medicine,Seoul,Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gi\u2010Won","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Liver Transplantation and Hepatobiliary Surgery,Department of Surgery,University of Ulsan College of Medicine,Asan Medical Center,Seoul,Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Liver Transplantation and Hepatobiliary Surgery,Department of Surgery,University of Ulsan College of Medicine,Asan Medical Center,Seoul,Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"lt25733-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/cld.222","article-title":"Expanding the donor pool in liver transplantation: extended criteria donors","volume":"2","year":"2013","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"lt25733-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1016\/j.transproceed.2006.08.077","article-title":"Influence of degree of hepatic steatosis on graft function and postoperative complications of liver transplantation","volume":"38","year":"2006","journal-title":"Transplant Proc"},{"key":"lt25733-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/lt.22085","article-title":"The biopsied donor liver: incorporating macrosteatosis into 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