{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:11:18Z","timestamp":1790428278331,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>The aim of this study was to analyze longterm patient and graft survival after liver transplantation for autoimmune hepatitis (AIH\u2010LT) from the prospective multicenter European Liver Transplant Registry. Patient and liver graft survival between 1998 and 2017 were analyzed. Patients after AIH\u2010LT (n\u00a0=\u00a02515) were compared with patients receiving LT for primary biliary cholangitis (PBC\u2010LT; n\u00a0=\u00a03733), primary sclerosing cholangitis (PSC\u2010LT; n\u00a0=\u00a05155), and alcohol\u2010related cirrhosis (AC\u2010LT; n\u00a0=\u00a019,567). After AIH\u2010LT, patient survival was 79.4%, 70.8%, and 60.3% and graft survival was 73.2%, 63.4%, and 50.9% after 5, 10, and 15 years of follow\u2010up. Overall patient survival was similar to patients after AC\u2010LT (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.44), but worse than after PBC\u2010LT (hazard ratio [HR],\u00a01.48; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001) and PSC\u2010LT (HR,\u00a01.19; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.002). AIH\u2010LT patients were at increased risk for death (HR,\u00a01.37\u20101.84; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001) and graft loss (HR,\u00a01.35\u20101.80; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001) from infections compared with all other groups and had a particularly increased risk for lethal fungal infections (HR,\u00a03.38\u20104.20; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0\u2264\u00a00.004). Excluding patients who died within 90 days after LT, risk of death after AIH\u2010LT was superior compared with AC\u2010LT (HR,\u00a00.84; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.004), worse compared with PBC\u2010LT (HR,\u00a01.38; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001) and similar compared with PSC\u2010LT (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.93). Autoimmune hepatitis (AIH) patients with living donor liver transplantation (LDLT) showed reduced survival compared with patients receiving donation after brain death (HR,\u00a01.96; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001). In AIH\u2010LT patients, overall survival is inferior to PBC\u2010LT and PSC\u2010LT. The high risk of death after AIH\u2010LT is caused mainly by early fatal infections, including fungal infections. Patients with LDLT for AIH show reduced survival.<\/jats:p>","DOI":"10.1002\/lt.25739","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T03:35:46Z","timestamp":1582947346000},"page":"866-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Longterm Survival After Liver Transplantation for Autoimmune Hepatitis: Results From the European Liver Transplant Registry"],"prefix":"10.1097","volume":"26","author":[{"given":"Melina","family":"Heinemann","sequence":"first","affiliation":[{"name":"I. Department of Medicine,University Medical Center Hamburg\u2010Eppendorf,Hamburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Adam","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary Center,AP\u2010HP Paul Brousse Hospital,University of Paris\u2010Sud,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Liver Transplantation and Hepatology Unit,La Fe University Hospital,Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas,University of Valencia,Valencia,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Mirza","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery,Queen Elizabeth Hospital,Birmingham,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ali","family":"Malek\u2010Hosseini","sequence":"additional","affiliation":[{"name":"Avicenna Center for Medicine and Organ Transplant,Shiraz University of Medical Sciences,Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"O\u2019Grady","sequence":"additional","affiliation":[{"name":"King\u2019s Liver Transplant Unit,King\u2019s College Hospital NHS Foundation Trust,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lodge","sequence":"additional","affiliation":[{"name":"The Leeds Teaching Hospitals NHS Trust,Leeds,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Pratschke","sequence":"additional","affiliation":[{"name":"Department of Surgery,Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin,Campus Charit\u00e9 Mitte and Campus Virchow Klinikum,Berlin,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Boudjema","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Digestive Surgery,Pontchaillou University Hospital,Rennes,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplant Surgery,University Hospital Essen,Essen,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Zieniewicz","sequence":"additional","affiliation":[{"name":"Department of General, Transplant and Liver Surgery,Medical University of Warsaw,Warsaw,Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Fronek","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery,Institute for Clinical and Experimental Medicine,Prague,Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Heinz","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV,University Hospital Heidelberg,Heidelberg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Karam","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary Center,AP\u2010HP Paul Brousse Hospital,University of Paris\u2010Sud,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Duvoux","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology,University Hospital of Henri\u2010Mondor,Creteil,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Lohse","sequence":"additional","affiliation":[{"name":"I. Department of Medicine,University Medical Center Hamburg\u2010Eppendorf,Hamburg,Germany"},{"name":"Martin Zeitz Center for Rare Diseases,University Medical Centre Hamburg\u2010Eppendorf,Hamburg,Germany"},{"name":"European Reference Network for Hepatological Diseases,Hamburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schramm","sequence":"additional","affiliation":[{"name":"I. Department of Medicine,University Medical Center Hamburg\u2010Eppendorf,Hamburg,Germany"},{"name":"Martin Zeitz Center for Rare Diseases,University Medical Centre Hamburg\u2010Eppendorf,Hamburg,Germany"},{"name":"European Reference Network for Hepatological Diseases,Hamburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"all the other contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"lt25739-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.jhep.2015.06.030","article-title":"EASL clinical practice guidelines: autoimmune hepatitis","volume":"63","year":"2015","journal-title":"J 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