{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:18:02Z","timestamp":1790720282077,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Longterm use of a calcineurin inhibitor (CNI)\u2013based regimen is one of the major reasons for chronic renal failure in liver transplantation recipients (LTRs). The Everolimus Liver registry (EVEROLIVER) evaluated renal function in LTRs who were converted to everolimus (EVR). This observational registry included all LTRs receiving EVR across 9 centers from France. Data are being collected in an electronic database over 10 years (12 visits\/patient) to evaluate efficacy, renal function (estimated glomerular filtration rate [eGFR]), and safety of EVR use in clinical practice, and the current analysis is reporting up to 60\u00a0months of findings. Until September 2017, 1045 patients received EVR after a mean time of 3.6\u00a0\u00b1\u00a05.1\u00a0years. CNI withdrawal was feasible in 57.7% of patients as of month 60. Mean eGFR improved in patients with baseline eGFR &lt;60\u00a0mL\/minute\/1.73\u00a0m<jats:sup>2<\/jats:sup> and was maintained in those with baseline eGFR \u226560\u00a0mL\/minute\/1.73\u00a0m<jats:sup>2<\/jats:sup>. Among patients with chronic kidney disease (CKD; baseline eGFR &lt;60\u00a0mL\/minute\/1.73\u00a0m<jats:sup>2<\/jats:sup>), 55% converted to EVR within 3 months (early conversion) and 39.4% converted between 4 and 12\u00a0months after transplantation (mid\u2010conversion) experienced improvement in eGFR (\u226560\u00a0mL\/minute\/1.73\u00a0m<jats:sup>2<\/jats:sup>) at month 36. Only 20.9% and 17.4% among those converted beyond 12\u00a0months (late conversion) experienced improvement respectively at month 36 and 60. A logistic regression analysis in patients with CKD stage \u22653 demonstrated that late conversion, age, and female sex were associated with nonimprovement of eGFR (\u226560\u00a0mL\/minute\/1.73\u00a0m<jats:sup>2<\/jats:sup>). Data from this real\u2010life use of EVR indicate that renal function was maintained from the preconversion period until month 36 even in patients with advanced CKD. However, early rather than late conversion appears to be a safe approach to preserve longterm renal function in LTRs.<\/jats:p>","DOI":"10.1002\/lt.25879","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T04:54:21Z","timestamp":1598936061000},"page":"1465-1476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Time to Conversion to an Everolimus\u2010Based Regimen: Renal Outcomes in Liver Transplant Recipients From the EVEROLIVER Registry"],"prefix":"10.1097","volume":"26","author":[{"given":"Faouzi","family":"Saliba","sequence":"first","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire,AP\u2010HP H\u00f4pital Paul Brousse,INSERM, Unit\u00e9 1193,Universit\u00e9 Paris Saclay,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Dharancy","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato\u2010Gastroent\u00e9rologie,Centre Hospitalier Universitaire de Lille,Lille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ephrem","family":"Salam\u00e9","sequence":"additional","affiliation":[{"name":"Service de Chirurgie H\u00e9pato\u2010Biliaire et Digestive,H\u00f4pital Trousseau, Centre Hospitalier Universitaire Tours,Tours,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filom\u00e9na","family":"Conti","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive et H\u00e9pato\u2010Biliaire,AP\u2010HP H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re,Transplantation H\u00e9patique,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Eyraud","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Anesth\u00e9sie\u2010R\u00e9animation,Service de Chirurgie Digestive et H\u00e9pato\u2010Biliaire et de Transplantation H\u00e9patique,Groupe Hospitalier Piti\u00e9 Salp\u00eatri\u00e8re,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Radenne","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive et Transplantation H\u00e9patique,H\u00f4pital la Croix Rousse,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e9r\u00e9sa","family":"Antonini","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire,AP\u2010HP H\u00f4pital Paul Brousse,INSERM, Unit\u00e9 1193,Universit\u00e9 Paris Saclay,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Guillaud","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Transplantation H\u00e9patique,H\u00f4pital Edouard Herriot,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Guguenheim","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chirurgie Digestive et Transplantation H\u00e9patique,H\u00f4pital Archet,University of Nice Sophia Antipolis,Nice,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Neau\u2010Cransac","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Chirurgie H\u00e9pato\u2010Biliaire et de Transplantation H\u00e9patique,H\u00f4pital Magellan, Centre Hospitalier Universitaire Bordeaux,Pessac,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00e9onora","family":"Demartin","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire,AP\u2010HP H\u00f4pital Paul Brousse,INSERM, Unit\u00e9 1193,Universit\u00e9 Paris Saclay,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lasailly","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato\u2010Gastroent\u00e9rologie,Centre Hospitalier Universitaire de Lille,Lille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Duvoux","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie,AP\u2010HP H\u00f4pital Henri Mondor,Cr\u00e9teil,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolphe","family":"Sobesky","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire,AP\u2010HP H\u00f4pital Paul Brousse,INSERM, Unit\u00e9 1193,Universit\u00e9 Paris Saclay,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Coilly","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire,AP\u2010HP H\u00f4pital Paul Brousse,INSERM, Unit\u00e9 1193,Universit\u00e9 Paris Saclay,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Tresson","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire,AP\u2010HP H\u00f4pital Paul Brousse,INSERM, Unit\u00e9 1193,Universit\u00e9 Paris Saclay,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Cailliez","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire,AP\u2010HP H\u00f4pital Paul Brousse,INSERM, Unit\u00e9 1193,Universit\u00e9 Paris Saclay,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Boillot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Transplantation H\u00e9patique,H\u00f4pital Edouard Herriot,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges Philippe","family":"Pageaux","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie,Centre Hospitalier Universitaire Montpellier,Montpellier,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Samuel","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire,AP\u2010HP H\u00f4pital Paul Brousse,INSERM, Unit\u00e9 1193,Universit\u00e9 Paris Saclay,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvon","family":"Calmus","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive et H\u00e9pato\u2010Biliaire,AP\u2010HP H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re,Transplantation H\u00e9patique,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Dumortier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Transplantation H\u00e9patique,H\u00f4pital Edouard Herriot,Lyon,France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"lt25879-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMoa021744","article-title":"Chronic renal failure after transplantation of a nonrenal organ","volume":"349","year":"2003","journal-title":"N Engl J Med"},{"key":"lt25879-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1111\/ajt.13765","article-title":"Protecting the kidney in liver transplant recipients: practice\u2010based recommendations from the American Society of Transplantation Liver and Intestine Community of Practice","volume":"16","year":"2016","journal-title":"Am J Transplant"},{"key":"lt25879-bib-0003-20240115","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5414\/CNP75150","article-title":"Chronic kidney disease after orthotopic liver transplantation in recipients receiving tacrolimus","volume":"75","year":"2011","journal-title":"Clin Nephrol"},{"key":"lt25879-bib-0004-20240115","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1053\/jlts.2003.50113","article-title":"Independent risk factors and natural history of renal dysfunction in liver transplant recipients","volume":"9","year":"2003","journal-title":"Liver Transpl"},{"key":"lt25879-bib-0005-20240115","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/lt.21803","article-title":"Long\u2010term renal function in liver transplant recipients and impact of immunosuppressive regimens (calcineurin inhibitors alone or in combination with mycophenolate mofetil): the TRY study","volume":"15","year":"2009","journal-title":"Liver Transpl"},{"key":"lt25879-bib-0006-20240115","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1600-6143.2005.00852.x","article-title":"Renal histopathological lesions after orthotopic liver transplantation (OLT)","volume":"5","year":"2005","journal-title":"Am J Transplant"},{"key":"lt25879-bib-0007-20240115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.12659\/AOT.902523","article-title":"Real\u2010world multicenter experience of immunosuppression minimization among 661 liver transplant recipients","volume":"22","year":"2017","journal-title":"Ann Transplant"},{"key":"lt25879-bib-0008-20240115","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1499-3872(15)60419-2","article-title":"Everolimus in de novo liver transplant recipients: a systematic review","volume":"14","year":"2015","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"lt25879-bib-0009-20240115","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1111\/j.1600-6143.2012.04212.x","article-title":"Everolimus with reduced tacrolimus improves renal function in de novo liver transplant recipients: a randomized controlled trial","volume":"12","year":"2012","journal-title":"Am J 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