{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:01:20Z","timestamp":1785520880144,"version":"3.56.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Infections in patients with cirrhosis are associated with liver\u2010related complications (LRCs), especially in patients awaiting liver transplantation (LT). The aim of this study was to evaluate the impact of methicillin\u2010resistant <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic> (MRSA) and extended spectrum beta\u2010lactamase colonization on infections and LRCs for patients on the wait list and on infections after LT. We retrospectively included 250 of 483 patients with cirrhosis who were placed on the wait list for LT from December 2015 to January 2018. These patients were screened for MRSA or extended spectrum beta\u2010lactamase\u2013producing Enterobacteriaceae (ESBLE) at the time of wait\u2010list placement and after LT. Of the patients, 76% were male with a mean age of 57.5\u00a0\u00b1\u00a010 years, and the most frequent cause of liver disease was alcohol (39%). Median Model for End\u2010Stage Liver Disease (MELD) score was 19 (12\u201028). Only 1 patient was positive for MRSA; 19% of patients (n\u00a0=\u00a047) had ESBLE fecal carriage at the time of wait\u2010list placement and 15% (n\u00a0=\u00a037) had it after LT. Infection\u2010free survival on the wait list and after LT, according to fecal carriage status, was not statistically different between 2 groups. LRC\u2010free survival at 6 and 12\u00a0months was significantly lower in ESBLE fecal carriage (HR, 1.6; <jats:italic toggle=\"yes\">P<\/jats:italic> =\u00a00.04). MELD score &gt;19 (HR, 3.0; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.01) and occurrence of infection during the first 3\u00a0months on the wait list (HR, 4.13; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001) were independent risk factors for LRC occurrence in the multivariate analysis. Our study is the first showing that in a cohort of patients with cirrhosis waiting for LT LRC\u2010free survival was lower in patients with ESBLE fecal carriage but that infection\u2010free survival was not different between the 2 groups.<\/jats:p>","DOI":"10.1002\/lt.25897","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T19:26:08Z","timestamp":1600716368000},"page":"43-54","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Consequences of Extended Spectrum Beta\u2010Lactamase\u2013Producing Enterobacteriaceae and Methicillin\u2010Resistant Staphylococcus aureus Carriage in Awaiting Liver Transplant Patients"],"prefix":"10.1097","volume":"27","author":[{"given":"Bianca","family":"Magro","sequence":"first","affiliation":[{"name":"Liver Transplantation Unit,H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re,APHP,Paris,France"},{"name":"Section of Gastroenterology and Hepatology,Department of Health Promotion, Mother and Child Care,Internal Medicine and Medical Specialties,University of Palermo,Palermo,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Mazzola","sequence":"additional","affiliation":[{"name":"Liver Transplantation Unit,H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re,APHP,Paris,France"},{"name":"Research Center of Saint\u2010Antoine,INSERM U938,Sorbonne Universit\u00e9,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Nutrition Institute,INSERM,Sorbonne Universit\u00e9,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Goumard","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary and Liver Transplantation Surgical Unit,H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re,APHP,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Martinez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit,H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re,APHP,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Bernard","sequence":"additional","affiliation":[{"name":"Intensive Care Unit,H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re,APHP,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Scatton","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary and Liver Transplantation Surgical Unit,H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re,APHP,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Department of Economics, Business and Statistics,University of Palermo,Palermo,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Celsa","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology,Department of Health Promotion, Mother and Child Care,Internal Medicine and Medical Specialties,University of Palermo,Palermo,Italy"},{"name":"Department of Surgical, Oncological and Oral Sciences,University of Palermo,Palermo,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calogero","family":"Camm\u00e0","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology,Department of Health Promotion, Mother and Child Care,Internal Medicine and Medical Specialties,University of Palermo,Palermo,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Conti","sequence":"additional","affiliation":[{"name":"Liver Transplantation Unit,H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re,APHP,Paris,France"},{"name":"Research Center of Saint\u2010Antoine,INSERM U938,Sorbonne Universit\u00e9,Paris,France"},{"name":"Nutrition Institute,INSERM,Sorbonne Universit\u00e9,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"lt25897-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.jhep.2014.01.024","article-title":"Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013","volume":"60","year":"2014","journal-title":"J Hepatol"},{"key":"lt25897-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1053\/j.gastro.2010.06.019","article-title":"Infections in patients with cirrhosis increase mortality four\u2010fold and should be used in determining 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