{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:45:45Z","timestamp":1790232345357,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Presentation of autoimmune hepatitis (AIH) can differ from nonacute to acute autoimmune hepatitis (A\u2010AIH) with jaundice and acute severe autoimmune hepatitis (AS\u2010AIH) with jaundice and coagulopathy. The aim of the study was to evaluate the short\u2010term prognosis of different presentations of AIH and the influence of liver function improvement on short\u2010term prognosis. In this single\u2010center retrospective cohort study, AIH patients with repeatedly tested liver function at diagnosis and during at least 1\u00a0year of follow\u2010up were included. A\u2010AIH was defined as bilirubin &gt;45\u00a0\u00b5mol and international normalized ratio (INR) &lt;1.5. AS\u2010AIH was defined as bilirubin level &gt;45\u00a0\u00b5mol\/L and INR \u22651.5. Of the 81 included patients, 17 (21%) presented with A\u2010AIH, and 14 (17%) presented with AS\u2010AIH. After the start of immunosuppressive therapy, bilirubin, albumin, and INR normalized in 70%, 77%, and 69%, respectively, in a median of 2.6\u00a0months, 3\u00a0months, and 4\u00a0weeks, respectively, in patients with A\u2010AIH and AS\u2010AIH. Liver transplantation (LT)\u2013free survival rate was 100% in nonacute AIH, 94% in A\u2010AIH, and 57% in AS\u2010AIH at 12 months after diagnosis. An increase of INR or bilirubin at 2\u00a0weeks was the best predictive factor for the need of LT within 12\u00a0months with a Youden\u2019s index of 0.85. A\u2010AIH was present in 21%, and AS\u2010AIH was present in 17% of AIH patients. In the majority of patients, bilirubin, albumin, and INR normalized in the first months of treatment. Deterioration of liver function after 2 weeks of treatment should lead to rapid evaluation for LT and consideration of second\u2010line medication.<\/jats:p>","DOI":"10.1002\/lt.25906","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T19:47:08Z","timestamp":1601495228000},"page":"1573-1581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Early Predictors of Short\u2010Term Prognosis in Acute and Acute Severe Autoimmune Hepatitis"],"prefix":"10.1097","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2797-6164","authenticated-orcid":false,"given":"Maaike","family":"Biewenga","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Leiden University Medical Center,Leiden,2300 RC,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akin","family":"Inderson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Leiden University Medical Center,Leiden,2300 RC,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten E.","family":"Tushuizen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Leiden University Medical Center,Leiden,2300 RC,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Stijn L.P.","family":"Crobach","sequence":"additional","affiliation":[{"name":"Department of Pathology,Leiden University Medical Center,Leiden,2300 RC,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-764X","authenticated-orcid":false,"given":"Bart","family":"van Hoek","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Leiden University Medical Center,Leiden,2300 RC,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"lt25906-bib-0001-20240115","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.3748\/wjg.v22.i19.4651","article-title":"Auto immune hepatitis","volume":"22","year":"2016","journal-title":"World J Gastroenterol"},{"key":"lt25906-bib-0002-20240115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/hep.20732","article-title":"Autoimmune 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