{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:47:38Z","timestamp":1789001258720,"version":"build-2803163510"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl."],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>After liver transplantation (LT), the role of ursodeoxycholic acid (UDCA) is not well characterized. We examine the effect of UDCA after LT in the prophylaxis of biliary complications (BCs) in all\u2010comers for LT and the prevention of recurrent primary biliary cholangitis (rPBC) in patients transplanted for PBC. Two authors searched PubMed\/MEDLINE and Embase from January 1990 through December 2018 to identify all studies that evaluate the effectiveness of UDCA prophylaxis after LT for BCs in all LT recipients and rPBC after LT in patients transplanted for PBC. Odds ratios (ORs) were calculated for endpoints of the BC study. Pooled recurrence rates were calculated for rPBC. The study was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta\u2010Analysis guidelines. A total of 15 studies were included, comprising 530 patients in the analysis for BCs and 1727 patients in the analysis for rPBC. UDCA was associated with decreased odds of BCs (OR, 0.70; 95% confidence interval [CI], 0.52\u20100.93; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.01) and biliary stones and sludge (OR, 0.49; 95% CI, 0.24\u20100.77; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.004). Prophylactic use of UDCA did not affect the odds of biliary stricture. For patients transplanted for PBC, the rate of rPBC was lower with the prophylactic use of UDCA (IR 16.7%; 95% CI, 0.114%\u201022.0%; I2 = 36.1%) compared with not using prophylactic UDCA (IR 23.1%; 95% CI, 16.9%\u201029.3%; I2 = 86.7%). UDCA after LT reduces the odds of BC and bile stones and sludge in all\u2010comer LT recipients and reduces or delays the incidence of rPBC in patients transplanted for PBC. UDCA use after LT could be considered in all LT recipients to reduce the odds of BC and may be particularly beneficial for patients transplanted for PBC by reducing the incidence of rPBC.<\/jats:p>","DOI":"10.1002\/lt.25935","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T06:22:52Z","timestamp":1605248572000},"page":"866-875","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":35,"title":["Ursodeoxycholic Acid Decreases Incidence of Primary Biliary Cholangitis and Biliary Complications After Liver Transplantation: A Meta\u2010Analysis"],"prefix":"10.1097","volume":"27","author":[{"given":"Mark R.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Division of Digestive and Liver Diseases,Department of Internal Medicine,The University of Texas Southwestern Medical Center,Dallas,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett","family":"Greenan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,The University of Texas Southwestern Medical Center,Dallas,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumant","family":"Arora","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,University of Iowa,Iowa City,IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind R.","family":"Murali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,University of Iowa,Iowa City,IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlyn J.","family":"Mayo","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases,Department of Internal Medicine,The University of Texas Southwestern Medical Center,Dallas,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"lt25935-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/S0016-5085(19)30493-7","article-title":"Effect of high and low doses of ursodeoxycholic acid on gallstone dissolution in humans","volume":"78","year":"1980","journal-title":"Gastroenterology"},{"key":"lt25935-bib-0002-20250824","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S1499-3872(14)60260-5","article-title":"Efficacy of ursodeoxycholic acid as an adjuvant treatment to prevent acute cellular rejection after liver transplantation: a meta\u2010analysis of randomized controlled trials","volume":"13","year":"2014","journal-title":"Hepatobiliary Pancreatic Dis Int"},{"key":"lt25935-bib-0003-20250824","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.14309\/00000434-201410002-00549","article-title":"Early postoperative 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