{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:32:31Z","timestamp":1793928751596,"version":"4.8.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl."],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>The Stanford Integrated Psychosocial Assessment for Transplant (SIPAT) is a standardized psychosocial evaluation tool used in liver transplantation (LT) evaluation. We assessed the impact of the SIPAT score and subdomains on transplant waitlisting decisions and post\u2010LT outcomes including immunosuppression (IS) nonadherence, biopsy\u2010proven rejection, andmortality\/graft failure. We conducted a single\u2010center observational cohort study of 1430 patients evaluated for LT. Patients were divided in 2 groups based on a SIPAT cutoff score of &lt;21 or \u226521 (higher SIPAT scores indicate higher psychosocial risk). Regression models assessed relationships between total SIPAT score and domain scores and waitlisting decisions, IS nonadherence, allograft rejection, and death\/graft failure. Elevated total SIPAT and SIPAT domain scores were associated not being added to the waitlist (total SIPAT core \u226521 adjusted odds ratio [aOR], 1.78 [95% confidence interval, CI, 1.36\u20102.33]; readiness score \u22655 aOR, 2.01 [95% CI, 1.36\u20102.76]; social support score \u22654aOR, 1.50 [95% CI, 1.15\u20101.94]; psychopathology score \u22657 aOR, 1.45 [95% CI, 1.07\u20101.94]; lifestyle\/substance abuse score \u226512 aOR, 1.72 [95%CI, 1.23\u20102.39]) and were more likely to experience IS nonadherence as measured by the tacrolimus coefficient of variation (CoV) (total SIPAT score \u226521 aOR, 2.92 [95% CI, 1.69\u20105.03]; readiness score \u22655 aOR, 3.26 [95% CI, 1.63\u20106.52]; psychopathology score \u22657 aOR, 1.88 [95% CI, 1.00\u20103.50]; lifestyle substance abuse score \u226512 aOR, 3.03 [95% CI, 1.56\u20105.86]). SIPAT readinessscore \u22655 was associated with biopsy\u2010proven allograft rejection (aOR, 2.66; 95% CI, 1.20\u20105.91). The SIPAT score was independently associated with LT listing decisions and IS nonadherence, and the readiness domain was associated with the risk of allograft rejection. These findings offer insights into higher risk recipients who require additional support before and aftertransplantation.<\/jats:p>","DOI":"10.1002\/lt.25975","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T22:24:51Z","timestamp":1608416691000},"page":"652-667","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":80,"title":["The Stanford Integrated Psychosocial Assessment for Transplant Is Associated With Outcomes Before and After Liver Transplantation"],"prefix":"10.1097","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0923-4300","authenticated-orcid":false,"given":"Sasha","family":"Deutsch\u2010Link","sequence":"first","affiliation":[{"name":"Department of Gastroenterology & Hepatology,University of North Carolina\u2013Chapel Hill,Chapel Hill,NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan M.","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology,University of Pennsylvania Perelman School of Medicine,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Bittermann","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology,University of Pennsylvania Perelman School of Medicine,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie","family":"McDougal","sequence":"additional","affiliation":[{"name":"Department of Medicine,Drexel University College of Medicine,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniket","family":"Dhariwal","sequence":"additional","affiliation":[{"name":"Department of Medicine,University of Pennsylvania,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren S.","family":"Jones","sequence":"additional","affiliation":[{"name":"Philadelphia College of Osteopathic Medicine,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Weinrieb","sequence":"additional","affiliation":[{"name":"Department of Psychiatry,University of Pennsylvania Perelman School of Medicine,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpita G.","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry,University of Pennsylvania Perelman School of Medicine,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senayish","family":"Addis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology,University of Pennsylvania Perelman School of Medicine,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Serper","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology,University of Pennsylvania Perelman School of Medicine,Philadelphia,PA"},{"name":"Leonard Davis Institute of Health Economics,University of Pennsylvania Perelman School of Medicine,Philadelphia,PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"lt25975-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/152692480001000408","article-title":"Psychosocial assessments and outcomes in organ transplantation","volume":"10","year":"2000","journal-title":"Prog Transplant"},{"key":"lt25975-bib-0002-20250824","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.psym.2011.12.012","article-title":"The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT): a new tool for the psychosocial evaluation of pre\u2010transplant candidates","volume":"53","year":"2012","journal-title":"Psychosomatics"},{"key":"lt25975-bib-0003-20250824","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0033-3182(95)71662-0","article-title":"Psychosocial assessment of organ transplant candidates. 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