{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:55:37Z","timestamp":1761630937481,"version":"3.44.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl."],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Although recent studies have reported favorable outcomes in living donor liver transplantation (LDLT), it remains unclear which populations benefit most from LDLT. This study aims to evaluate LDLT outcomes compared with deceased donor LT (DDLT) according to Model for End\u2010Stage Liver Disease (MELD) score categories. Using data from the United Network for Organ Sharing registry, outcomes were compared between 1486 LDLTs; 13,568 donation after brain death (DBD)\u2010DDLTs; and 1171 donation after circulatory death (DCD)\u2010DDLTs between 2009 and 2018. Because LDLT for patients with MELD scores &gt;30 was rare, all patients with scores &gt;30 were excluded to equalize LDLT and DDLT cohorts. Risk factors for 1\u2010year graft loss (GL) were determined separately for LDLT and DDLT. Compared with LDLT, DBD\u2010DDLT had a lower risk of 30\u2010day (adjusted hazard ratio [aHR], 0.60; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001) and 1\u2010year GL (aHR, 0.57; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). The lower risk of GL was more prominent in the mid\u2010MELD score category (score 15\u201029). Compared with LDLT, DCD\u2010DDLT had a lower risk of 30\u2010day GL but a comparable risk of 1\u2010year GL, regardless of MELD score category. In LDLT, significant ascites was an independent risk for GL in patients with mid\u2010MELD scores (aHR, 1.68; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.02), but not in the lower\u2010MELD score group. The risk of 1\u2010year GL in LDLT patients with ascites who received a left liver was higher than either those who received a right liver or those without ascites who received a left liver. In LDLT, combinations of MELD scores of 15 to 29, moderate\/severe ascites, and the use of a left liver are associated with worse outcomes. These findings help calibrate appropriate patient and graft selection in LDLT.<\/jats:p>","DOI":"10.1002\/lt.25993","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T15:31:56Z","timestamp":1611588716000},"page":"971-983","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes in Living Donor Compared With Deceased Donor Primary Liver Transplantation in Lower Acuity Patients With Model for End\u2010Stage Liver Disease Scores\u00a0&lt;30"],"prefix":"10.1097","volume":"27","author":[{"given":"Toshihiro","family":"Kitajima","sequence":"first","affiliation":[{"name":"Departments of Transplant and Hepatobiliary Surgery,Henry Ford Hospital,Detroit,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilip","family":"Moonka","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology,Henry Ford Hospital,Detroit,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirisha","family":"Yeddula","sequence":"additional","affiliation":[{"name":"Departments of Transplant and Hepatobiliary Surgery,Henry Ford Hospital,Detroit,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Collins","sequence":"additional","affiliation":[{"name":"Departments of Transplant and Hepatobiliary Surgery,Henry Ford Hospital,Detroit,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rizzari","sequence":"additional","affiliation":[{"name":"Departments of Transplant and Hepatobiliary Surgery,Henry Ford Hospital,Detroit,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Departments of Transplant and Hepatobiliary Surgery,Henry Ford Hospital,Detroit,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan S.","family":"Abouljoud","sequence":"additional","affiliation":[{"name":"Departments of Transplant and Hepatobiliary Surgery,Henry Ford Hospital,Detroit,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2612-8427","authenticated-orcid":false,"given":"Shunji","family":"Nagai","sequence":"additional","affiliation":[{"name":"Departments of Transplant and Hepatobiliary Surgery,Henry Ford Hospital,Detroit,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"lt25993-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1097\/00007890-199811270-00008","article-title":"Adult living donor liver transplantation using a right hepatic lobe","volume":"66","year":"1998","journal-title":"Transplantation"},{"issue":"suppl 1","key":"lt25993-bib-0002-20250824","first-page":"193","article-title":"OPTN\/SRTR 2018 annual data report: liver","volume":"20","year":"2020","journal-title":"Am J Transplant"},{"key":"lt25993-bib-0003-20250824","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.1600-6143.2004.00522.x","article-title":"Allograft survival following adult\u2010to\u2010adult living donor liver transplantation","volume":"4","year":"2004","journal-title":"Am J Transplant"},{"key":"lt25993-bib-0004-20250824","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1053\/j.gastro.2008.02.092","article-title":"Live donors in liver transplantation","volume":"134","year":"2008","journal-title":"Gastroenterology"},{"key":"lt25993-bib-0005-20250824","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-6143.2004.00654.x","article-title":"Adult living donor versus deceased donor liver transplantation: a 6\u2010year single center experience","volume":"5","year":"2005","journal-title":"Am J 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