{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:22:12Z","timestamp":1790256132725,"version":"4.1.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>This study aimed to determine the factors associated with resolution of nonalcoholic fatty liver (NAFL) after lifestyle intervention in potential living liver donors as assessed by the gold standards in a longitudinal setting. This retrospective study included 115 potential living liver donors (mean age, 30.5\u00a0\u00b1\u00a07.5\u00a0years; 101 men) with NAFL who underwent paired liver biopsies and abdominal computed tomography (CT) examinations before and after lifestyle intervention between January 2011 and December 2018. Anthropometry, laboratory parameters, body composition, and hepatic steatosis (HS) were evaluated before and after lifestyle intervention. Anthropometry, laboratory parameters, body composition, and HS were significantly decreased after lifestyle intervention (all, <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001). Relative changes in HS were weakly correlated with relative changes in the visceral fat area (VFA; <jats:italic toggle=\"yes\">r<\/jats:italic>\u00a0=\u00a00.278; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.003) and subcutaneous fat area (<jats:italic toggle=\"yes\">r<\/jats:italic>\u00a0=\u00a00.382; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001), but not with body weight, body mass index, or skeletal muscle area. Patients with resolved NAFL after lifestyle intervention had significantly lower VFA at follow\u2010up than those with persistent NAFL (mean \u00b1 standard deviation, 69.8\u00a0\u00b1\u00a039.1 versus 91.5\u00a0\u00b1\u00a041.4\u00a0cm<jats:sup>2<\/jats:sup>; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.01). Multivariable logistic regression analysis demonstrated that the relative reduction of VFA (odds ratio per percent, 1.031; 95% confidence interval, 1.010\u20101.053; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.004) was a significant independent factor associated with resolved NAFL after lifestyle intervention. In potential living liver donors with NAFL, the reduction of VFA is a significant factor associated with the resolution of NAFL after lifestyle intervention.<\/jats:p>","DOI":"10.1002\/lt.26071","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T03:17:32Z","timestamp":1617938252000},"page":"1424-1431","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Reduction of Visceral Adiposity as a Predictor for Resolution of Nonalcoholic Fatty Liver in Potential Living Liver Donors"],"prefix":"10.1097","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6893-3136","authenticated-orcid":false,"given":"Sunyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiology and Research Institute of Radiological Science,Severance Hospital,Yonsei University College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6471-6727","authenticated-orcid":false,"given":"Kyoung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology,Asan Medical Center,University of Ulsan College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongjin","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering,Soongsil University,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeyong","family":"Park","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering,Soongsil University,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology,Asan Medical Center,University of Ulsan College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi\u2010Won","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Surgery,Asan Medical Center,University of Ulsan College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery,Asan Medical Center,University of Ulsan College of Medicine,Seoul,Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"lt26071-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2010Meta\u2010analytic assessment of prevalence, incidence, and 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