{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:44:52Z","timestamp":1792820692603,"version":"4.5.0"},"reference-count":95,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl."],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Acute kidney injury (AKI) is a common condition following liver transplantation (LT). It negatively impacts patient outcomes by increasing the chances of developing chronic kidney disease and reducing graft and patient survival rates. Multiple definitions of AKI have been proposed and used throughout the years, with the International Club of Ascites definition being the most widely now used for patients with cirrhosis. Multiple factors are associated with the development of post\u2010LT AKI and can be categorized into pre\u2010LT comorbidities, donor and recipient characteristics, operative factors, and post\u2010LT factors. Many of these factors can be optimized in an attempt to minimize the risk of AKI occurring and to improve renal function if AKI is already present. A special consideration during the post\u2010LT phase is needed for immunosuppression as certain immunosuppressive medications can be nephrotoxic. The calcineurin inhibitor tacrolimus (TAC) is the mainstay of immunosuppression but can result in AKI. Several strategies including use of the monoclonoal antibody basilixamab to allow for delayed initiation of tacrolimus therapy and minimization through combination and minimization or elimination of TAC through combination with mycophenolate mofetil or mammalian target of rapamycin inhibitors have been implemented to reverse and avoid AKI in the post\u2010LT setting. Renal replacement therapy may ultimately be required to support patients until recovery of AKI after LT. Overall, by improving renal function in post\u2010LT patients with AKI, outcomes can be improved.<\/jats:p>","DOI":"10.1002\/lt.26094","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T02:27:45Z","timestamp":1620527265000},"page":"1653-1664","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":69,"title":["Post\u2013Liver Transplant Acute Kidney Injury"],"prefix":"10.1097","volume":"27","author":[{"given":"Victor","family":"Dong","sequence":"first","affiliation":[{"name":"Interdepartmental Division of Critical Care,University of Toronto,Toronto,Alberta,Canada"},{"name":"Division of Gastroenterology (Liver Unit),University of Alberta,Edmonton,Alberta,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra K.","family":"Nadim","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension,University of Southern California,Los Angeles,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-1089","authenticated-orcid":false,"given":"Constantine J.","family":"Karvellas","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology (Liver Unit),University of Alberta,Edmonton,Alberta,Canada"},{"name":"Department of Critical Care Medicine,University of Alberta,Edmonton,Alberta,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"lt26094-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1097\/TP.0000000000002305","article-title":"Acute kidney injury after liver transplantation","volume":"102","year":"2018","journal-title":"Transplantation"},{"key":"lt26094-bib-0002-20250824","article-title":"Incidence and impact of acute kidney injury after liver transplantation: a meta\u2010analysis","volume":"8","year":"2019","journal-title":"J 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