{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:09:36Z","timestamp":1789049376942,"version":"build-2803163510"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>\n                    The aim is to explore the impact of the Kasai procedure (KP) and the length of native liver survival time (NLST) on outcomes of liver transplantation (LT). Patients with biliary atresia (BA), who underwent LT in Beijing Friendship Hospital from January 2017 to December 2019, were enrolled and divided into non\u2010KP (N\u2010KP) and post\u2010KP (P\u2010KP) groups. The patients in the P\u2010KP group were further divided into early failure (KP\u2010EF) defined by NLST &lt;1\u00a0year, medium failure (KP\u2010MF, NLST 1\u20105\u00a0years), and late failure (KP\u2010LF, NLST &gt;5\u00a0years) subgroups. Clinical data at baseline and during follow\u2010up were collected. The inverse probability of treatment weighting method was used to evaluate the independent effect of KP and the length of NLST on clinical outcomes. Among 197 patients with BA, the N\u2010KP group accounted for 43 (21.8%), KP\u2010EF 71 (46.1%), KP\u2010MF 59 (38.3%), and KP\u2010LF 24 (15.6%) cases, respectively. The N\u2010KP and KP\u2010EF groups had significantly longer hospitalization and intensive care unit stays after LT. Graft and overall survival rates were 93.0% in the N\u2010KP group and 97.4% in P\u2010KP group, respectively. The mortality rate in the P\u2010KP group were significantly lower compared with that of the N\u2010KP group with a hazard ratio (HR) of 0.2 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.02). The risks of biliary and vascular complications and cytomegalovirus (CMV) infection after LT were significantly higher in KP\u2010EF group than those in the KP\u2010MF and KP\u2010LF groups (HRs = 0.09, 0.2, and 0.3, respectively; all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). The KP significantly improved after LT overall survival. Patients with early native liver failure after KP have significantly higher risks for biliary and vascular complications and CMV infection.\n                  <\/jats:p>","DOI":"10.1002\/lt.26287","type":"journal-article","created":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T14:59:10Z","timestamp":1630853950000},"page":"224-235","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Impact of the Kasai Procedure and the Length of Native Liver Survival Time on Outcomes of Liver Transplantation for Biliary Atresia"],"prefix":"10.1097","volume":"28","author":[{"given":"Liwei","family":"Liu","sequence":"first","affiliation":[{"name":"Liver Research Center, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wei","sequence":"additional","affiliation":[{"name":"Liver Transplant Center, Clinical Center for Pediatric Liver Transplantation, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qu","sequence":"additional","affiliation":[{"name":"Liver Transplant Center, Clinical Center for Pediatric Liver Transplantation, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Liver Transplant Center, Clinical Center for Pediatric Liver Transplantation, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Liver Transplant Center, Clinical Center for Pediatric Liver Transplantation, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-3913","authenticated-orcid":false,"given":"Haiming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Liver Transplant Center, Clinical Center for Pediatric Liver Transplantation, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Evidence Base Medicine Unit,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Faculty of Health Sciences,McMaster University,Hamilton,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine\/Ronald Reagan Medical Center,University of California Los Angeles,Los Angeles,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Li","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"He","sequence":"additional","affiliation":[{"name":"Liver Transplant Center, Clinical Center for Pediatric Liver Transplantation, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jidong","family":"Jia","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1101-7994","authenticated-orcid":false,"given":"Liying","family":"Sun","sequence":"additional","affiliation":[{"name":"Liver Transplant Center, Clinical Center for Pediatric Liver Transplantation, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-4368","authenticated-orcid":false,"given":"Xinyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7031-2083","authenticated-orcid":false,"given":"Zhijun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Liver Transplant Center, Clinical Center for Pediatric Liver Transplantation, National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital, Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"lt26287-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3346\/jkms.2017.32.4.656","article-title":"Epidemiology of biliary atresia in Korea","volume":"32","year":"2017","journal-title":"J Korean Med Sci"},{"key":"lt26287-bib-0002-20250824","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jpeds.2012.12.085","article-title":"Biliary atresia in preterm infants in Taiwan: a nationwide survey","volume":"163","year":"2013","journal-title":"J Pediatr"},{"key":"lt26287-bib-0003-20250824","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/lt.24132","article-title":"Impact of Kasai portoenterostomy on liver transplantation outcomes: a retrospective cohort study of 347 children with biliary atresia","volume":"21","year":"2015","journal-title":"Liver Transpl"},{"key":"lt26287-bib-0004-20250824","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1001\/jama.2020.2727","article-title":"Newborn screening for biliary atresia","volume":"323","year":"2020","journal-title":"JAMA"},{"key":"lt26287-bib-0005-20250824","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.yapd.2017.03.012","article-title":"Biliary atresia: epidemiology, genetics, clinical update, and public health perspective","volume":"64","year":"2017","journal-title":"Adv Pediatr"},{"key":"lt26287-bib-0006-20250824","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/hep.29905","article-title":"Biliary atresia: clinical and research challenges for the twenty\u2010first century","volume":"68","year":"2018","journal-title":"Hepatology"},{"key":"lt26287-bib-0007-20250824","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jhep.2013.01.040","article-title":"Improving outcomes of biliary atresia: French national series 1986\u20102009","volume":"58","year":"2013","journal-title":"J Hepatol"},{"key":"lt26287-bib-0008-20250824","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.amsu.2021.01.052","article-title":"Short\u2010 and long\u2010term outcomes after Kasai operation for type III biliary atresia: twenty years of experience in a single tertiary Egyptian center\u2014a retrospective cohort study","volume":"62","year":"2021","journal-title":"Ann Med Surg"},{"key":"lt26287-bib-0009-20250824","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.jpedsurg.2018.07.022","article-title":"The effects of Kasai procedure on living donor liver transplantation for children with biliary atresia","volume":"54","year":"2019","journal-title":"J Pediatr Surg"},{"key":"lt26287-bib-0010-20250824","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.dld.2015.11.021","article-title":"Comparison of liver transplantation outcomes in biliary atresia patients with and without prior portoenterostomy: a meta\u2010analysis","volume":"48","year":"2016","journal-title":"Dig Liver Dis"},{"key":"lt26287-bib-0011-20250824","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1001\/jamasurg.2018.3180","article-title":"Biliary\u2010enteric drainage vs primary liver transplant as initial treatment for children with biliary atresia","volume":"154","year":"2019","journal-title":"JAMA Surg"},{"key":"lt26287-bib-0012-20250824","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1399-3046.2012.01677.x","article-title":"The impact of hepatic portoenterostomy on liver transplantation for the treatment of biliary atresia: early failure adversely affects outcome","volume":"16","year":"2012","journal-title":"Pediatr Transplant"},{"key":"lt26287-bib-0013-20250824","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jpedsurg.2018.06.028","article-title":"Surgical modifications of the Kasai hepatoportoenterostomy minimize invasiveness without compromising short\u2010 and medium\u2010term outcomes","volume":"54","year":"2019","journal-title":"J Pediatr Surg"},{"key":"lt26287-bib-0014-20250824","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.jpedsurg.2018.09.025","article-title":"Five\u2010year native liver survival analysis in biliary atresia from a single large Chinese center: the death\/liver transplantation hazard change and the importance of rapid early clearance of jaundice","volume":"54","year":"2019","journal-title":"J Pediatr Surg"},{"key":"lt26287-bib-0015-20250824","article-title":"Long\u2010term effects of Kasai portoenterostomy for biliary atresia treatment in Russia","volume":"10","year":"2020","journal-title":"Diagnostics"},{"key":"lt26287-bib-0016-20250824","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1002\/hep4.1602","article-title":"Modeling outcomes in children with biliary atresia with native liver after 2 years of age","volume":"4","year":"2020","journal-title":"Hepatol Commun"},{"key":"lt26287-bib-0017-20250824","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/01.mpg.0000189339.92891.64","article-title":"Long\u2010term prognosis of patients with biliary atresia: a 25 year summary","volume":"42","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"lt26287-bib-0018-20250824","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/lt.24796","article-title":"Living donor liver transplantation for post\u2010Kasai biliary atresia: analysis of pretransplant predictors of outcomes in infants","volume":"23","year":"2017","journal-title":"Liver Transpl"},{"key":"lt26287-bib-0019-20250824","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00007890-200207270-00006","article-title":"Development of a pediatric end\u2010stage liver disease score to predict poor outcome in children awaiting liver transplantation","volume":"74","year":"2002","journal-title":"Transplantation"},{"key":"lt26287-bib-0020-20250824","first-page":"487","article-title":"Height and weight standardized growth charts for Chinese children and adolescents aged 0 to 18 years","volume":"47","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"lt26287-bib-0021-20250824","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1148\/radiol.2311020963","article-title":"Spleen length in childhood with US: normal values based on age, sex, and somatometric parameters","volume":"231","year":"2004","journal-title":"Radiology"},{"key":"lt26287-bib-0022-20250824","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jhep.2010.05.004","article-title":"EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis","volume":"53","year":"2010","journal-title":"J Hepatol"},{"key":"lt26287-bib-0023-20250824","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12072-018-09923-2","article-title":"Chinese guidelines on the management of ascites and its related complications in cirrhosis","volume":"13","year":"2019","journal-title":"Hepatol Int"},{"key":"lt26287-bib-0024-20250824","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/j.jpedsurg.2015.08.041","article-title":"A pathological scoring system in the diagnosis and judgment of prognosis of biliary atresia","volume":"50","year":"2015","journal-title":"J Pediatr Surg"},{"key":"lt26287-bib-0025-20250824","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1001\/archsurg.2011.240","article-title":"Liver transplantation using organ donation after cardiac death: a clinical predictive index for graft failure\u2010free survival","volume":"146","year":"2011","journal-title":"Arch Surg"},{"key":"lt26287-bib-0026-20250824","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1097\/TP.0000000000003819","article-title":"Donor warm ischemia time in DCD liver transplantation\u2010working group report from the ILTS DCD, liver preservation, and machine perfusion consensus conference","volume":"105","year":"2021","journal-title":"Transplantation"},{"key":"lt26287-bib-0027-20250824","article-title":"The impact of implantation time during liver transplantation on outcome: a Eurotransplant cohort study","volume":"4","year":"2018","journal-title":"Transplant Direct"},{"key":"lt26287-bib-0028-20250824","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1600-6143.2006.01242.x","article-title":"Characteristics associated with liver graft failure: the concept of a donor risk index","volume":"6","year":"2006","journal-title":"Am J Transplant"},{"key":"lt26287-bib-0029-20250824","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1499-3872(13)60005-3","article-title":"The pre\u2010Kasai procedure in living donor liver transplantation for children with biliary atresia","volume":"12","year":"2013","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"lt26287-bib-0030-20250824","first-page":"13","article-title":"Living donor liver transplantations for pediatric patients withbiliary atresia in a single center: 306 cases","volume":"40","year":"2019","journal-title":"Chin J Organ Transplant"},{"key":"lt26287-bib-0031-20250824","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/0009922811406264","article-title":"The perinatal infection of cytomegalovirus is an important etiology for biliary atresia in China","volume":"51","year":"2012","journal-title":"Clin Pediatr"},{"key":"lt26287-bib-0032-20250824","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.jpedsurg.2015.03.001","article-title":"Cytomegalovirus\u2010associated biliary atresia: an aetiological and prognostic subgroup","volume":"50","year":"2015","journal-title":"J Pediatr Surg"},{"key":"lt26287-bib-0033-20250824","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/hep.24807","article-title":"Cytomegalovirus\u2010specific T\u2010cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells","volume":"55","year":"2012","journal-title":"Hepatology"},{"key":"lt26287-bib-0034-20250824","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1053\/j.gastro.2010.07.004","article-title":"Prognostic value of endoscopy in children with biliary atresia at risk for early development of varices and bleeding","volume":"139","year":"2010","journal-title":"Gastroenterology"},{"key":"lt26287-bib-0035-20250824","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jpedsurg.2003.09.019","article-title":"Portoenterostomy for biliary atresia: long\u2010term survival and prognosis after esophageal variceal bleeding","volume":"39","year":"2004","journal-title":"J Pediatr Surg"},{"key":"lt26287-bib-0036-20250824","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1097\/TP.0000000000002553","article-title":"Young people with biliary atresia requiring liver transplantation: a distinct population requiring specialist care","volume":"103","year":"2019","journal-title":"Transplantation"},{"key":"lt26287-bib-0037-20250824","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1067\/mpd.2001.115967","article-title":"Survival after first esophageal variceal hemorrhage in patients with biliary atresia","volume":"139","year":"2001","journal-title":"J Pediatr"},{"key":"lt26287-bib-0038-20250824","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/MCG.0000000000000013","article-title":"Native liver histology after successful portoenterostomy in biliary atresia","volume":"48","year":"2014","journal-title":"J Clin Gastroenterol"},{"key":"lt26287-bib-0039-20250824","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/lt.24640","article-title":"Biliary atresia: indications and timing of liver transplantation and optimization of pretransplant care","volume":"23","year":"2017","journal-title":"Liver Transpl"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lt.26287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lt.26287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/lt.26287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T21:05:06Z","timestamp":1756069506000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/lt.26287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.26287","relation":{},"ISSN":["1527-6465","1527-6473"],"issn-type":[{"value":"1527-6465","type":"print"},{"value":"1527-6473","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,1]]},"assertion":[{"value":"2021-05-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}