{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:27:14Z","timestamp":1772760434289,"version":"3.50.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Although transplant outcomes for biliary atresia (BA) have improved, there are few data to predict the risk of specific posttransplant complications. We therefore defined the impact of comorbidities in BA on posttransplant outcomes. Patients enrolled in the Society of Pediatric Liver Transplantation registry from 2011 to 2019 (n\u00a0=\u00a01034) were grouped by comorbidities of &gt;1.0% incidence: any supplemental feeding, dialysis, other abdominal surgery (not Kasai portoenterostomy [KPE]), hepatopulmonary syndrome, and cardiac disease requiring intervention. Demographic and outcome data were compared using the Kruskal\u2010Wallis, chi\u2010square, and log\u2010rank tests. Cox proportional hazards models and binary logistic regression were performed for modeling. Patients with BA with comorbidities comprised 77% (n\u00a0=\u00a0799) of our cohort and had evidence of greater medical acuity, including higher calculated Pediatric End\u2010Stage Liver Disease scores and hospitalizations in the intensive care unit before transplant (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001 for both) versus those without comorbidities. After transplant, patients with BA with comorbidities had more graft loss (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.02), longer initial hospitalization and intubation (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001 for both), and increased rates of reoperation (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.001) and culture\u2010proven infection (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001) within 30\u00a0days after transplant. Only patients with BA with comorbidities on supplemental feed had increased rates of patient death (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.02). Multivariate analysis identified lower <jats:italic toggle=\"yes\">z<\/jats:italic> weight and higher creatinine as risk factors for graft and patient loss in patients with BA with comorbidities. Prior KPE was protective against culture\u2010proven infection and vascular complications within 30 and 90\u00a0days, respectively. Patients with BA with comorbidities have evidence of higher medical acuity at transplant and reduced graft survival; however, they overall did not experience greater incidence of patient death. Our data provide organ\u2010system\u2013specific data to risk\u2010stratify patients with BA and posttransplant outcomes.<\/jats:p>","DOI":"10.1002\/lt.26376","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T11:40:37Z","timestamp":1637840437000},"page":"855-866","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Organ\u2010Specific Comorbidities Are Associated With Distinct Complications After Liver Transplantation for Biliary Atresia"],"prefix":"10.1097","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-8386","authenticated-orcid":false,"given":"Sarah A.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Pediatrics,Ann and Robert H. Lurie Children's Hospital of Chicago,Chicago,IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena","family":"Venkat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,University of Pittsburgh Medical Center,Pittsburgh,PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronen","family":"Arnon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,Mount Sinai School of Medicine,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vani V.","family":"Gopalareddy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,Levine Children\u2019s Hospital at Atrium Health,Charlotte,NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Surgery,University of California San Francisco,San Francisco,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah G.","family":"Anderson","sequence":"additional","affiliation":[{"name":"The Emmes Company LLC,Rockville,MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder","family":"Anand","sequence":"additional","affiliation":[{"name":"The Emmes Company LLC,Rockville,MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,Children\u2019s Mercy Hospital,Kansas City,MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Society of Pediatric Liver Transplantation","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"lt26376-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/hep.21790","article-title":"Screening and 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