{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:03:13Z","timestamp":1788397393923,"version":"build-2803163510"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Children who undergo liver transplantation are at risk for portal vein complications (PVCs) including thrombosis (PVT) and stenosis (PVS). Using multicenter data from the Society of Pediatric Liver Transplantation, we analyzed the prevalence, timing, and risk factors for PVC following a first liver transplantation, and assessed the potential impact of PVC on patient outcomes. Our cohort included 4278 patients, of whom 327 (7.6%) developed PVC. Multivariate analysis discovered several factors independently associated with PVC: younger recipient age, lower weight at time of transplantation, diagnosis of biliary atresia (BA), receiving a technical variant graft (TVG), warm ischemia time over 3 h, PVT in the recipient\u2019s pretransplantation native liver, and concurrent hepatic artery thrombosis (all <jats:italic toggle=\"yes\">p<\/jats:italic> &lt;\u00a00.05). Subgroup analysis of those with BA found higher prevalence in patients transplanted at less than 2 years of age and those with TVGs. There was no difference in PVC prevalence among patients with BA with vs. without prior Kasai portoenterostomy. Most PVT (77.7%) presented within 90 days after transplantation. Patients with PVC had a higher risk of graft failure (23.9% vs. 8.3%; adjusted hazard ratio [HR], 3.08; <jats:italic toggle=\"yes\">p<\/jats:italic> &lt;\u00a00.001) and a higher risk of death (16.4% vs. 8.9%; adjusted HR, 1.96; <jats:italic toggle=\"yes\">p<\/jats:italic> =\u00a00.01). Recurrence after retransplantation was similar to the overall prevalence in the cohort (8.2%). Our results recognize the common occurrence of PVC following pediatric liver transplantation, describe independently associated risk factors, and determine that patients with PVC have worse outcomes. Further studies are needed to improve PVC prevention, detection, and management strategies.<\/jats:p>","DOI":"10.1002\/lt.26412","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T07:19:53Z","timestamp":1643440793000},"page":"1196-1206","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["Portal vein complications and outcomes following pediatric liver transplantation: Data from the Society of Pediatric Liver Transplantation"],"prefix":"10.1097","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4762-530X","authenticated-orcid":false,"given":"James P.","family":"Stevens","sequence":"first","affiliation":[{"name":"12239,Department of Pediatrics,Emory University School of Medicine,Atlanta,Georgia,USA"},{"name":"Transplant Services,Children\u2019s Healthcare of Atlanta,Atlanta,Georgia,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijin","family":"Xiang","sequence":"additional","affiliation":[{"name":"12239,Department of Pediatrics,Emory University School of Medicine,Atlanta,Georgia,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traci","family":"Leong","sequence":"additional","affiliation":[{"name":"12239,Department of Pediatrics,Emory University School of Medicine,Atlanta,Georgia,USA"},{"name":"Biostatistics and Bioinformatics,Rollins School of Public Health,Emory University,Atlanta,Georgia,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8017-9228","authenticated-orcid":false,"given":"Kushal","family":"Naik","sequence":"additional","affiliation":[{"name":"Transplant Services,Children\u2019s Healthcare of Atlanta,Atlanta,Georgia,USA"},{"name":"Department of Epidemiology,Rollins School of Public Health,Emory University,Atlanta,Georgia,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6171-4731","authenticated-orcid":false,"given":"Nitika Arora","family":"Gupta","sequence":"additional","affiliation":[{"name":"12239,Department of Pediatrics,Emory University School of Medicine,Atlanta,Georgia,USA"},{"name":"Transplant Services,Children\u2019s Healthcare of Atlanta,Atlanta,Georgia,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"lt26412-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s11894-012-0257-5","article-title":"Portal vein complications after pediatric liver transplantation","volume":"14","year":"2012","journal-title":"Curr Gastroenterol Rep"},{"key":"lt26412-bib-0002-20250824","first-page":"221","article-title":"Vascular complications following liver 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