{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:57:50Z","timestamp":1780531070023,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":7001,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver Transpl"],"published-print":{"date-parts":[[1996,7]]},"DOI":"10.1002\/lt.500020402","type":"journal-article","created":{"date-parts":[[2005,12,15]],"date-time":"2005-12-15T18:27:15Z","timestamp":1134671235000},"page":"253-262","source":"Crossref","is-referenced-by-count":74,"title":["Famciclovir treatment of hepatitis B virus recurrence after liver transplantation: A pilot study"],"prefix":"10.1002","volume":"2","author":[{"given":"Martin","family":"Kr\u00fcger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Ludger","family":"Tillmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Trautwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Oldhafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansj\u00f6rg","family":"Maschek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus H. W.","family":"B\u00f6ker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph E.","family":"Broelsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Pichlmayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Manns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,15]]},"reference":[{"key":"10.1002\/lt.500020402-BIB1|cit1","first-page":"105","article-title":"Liver transplantation at the University of Pittsburgh, 1984 to 1990","volume":"1991","author":"Gordon","year":"1991","journal-title":"Clin Transpl"},{"key":"10.1002\/lt.500020402-BIB2|cit2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/hep.1840130402","article-title":"Orthotopic liver transplantation for patients with hepatitis B virus-related liver disease","volume":"13","author":"Todo","year":"1991","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB3|cit3","first-page":"667","article-title":"Evolution of hepatitis B virus liver disease after hepatic replacement. Practical and theoretical considerations","volume":"137","author":"Demetris","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1002\/lt.500020402-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1056\/NEJM199312163292503","article-title":"Liver transplantation in European patients with the hepatitis B surface antigen","volume":"329","author":"Samuel","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1002\/lt.500020402-BIB5|cit5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/hep.1840120202","article-title":"Extrahepatic hepatitis B virus DNA sequences in patients with acute hepatitis B infection","volume":"12","author":"Yoffe","year":"1990","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB6|cit6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/hep.1840160108","article-title":"Hepatitis B virus DNA in peripheral-blood mononuclear cells in chronic hepatitis B after HBsAg clearance","volume":"16","author":"Mason","year":"1992","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB7|cit7","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/hep.1840130429","article-title":"Liver transplantation for patients with hepatitis B: what have we learned from our results?","volume":"13","author":"Lake","year":"1991","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB8|cit8","first-page":"4051","article-title":"Long-term immunoprophylaxis of hepatitis B virus reinfection in recipients of human liver allografts","volume":"19","author":"Lauchart","year":"1987","journal-title":"Transplant Proc"},{"key":"10.1002\/lt.500020402-BIB9|cit9","first-page":"637","article-title":"Prevention of viral recurrence following liver transplantation for post-hepatitis B and B-delta cirrhosis","volume":"124","author":"Mentha","year":"1994","journal-title":"Schweiz Med Wochenschr"},{"key":"10.1002\/lt.500020402-BIB10|cit10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/hep.1840190103","article-title":"Pretransplantation interferon treatment and recurrence of hepatitis B virus infection after liver transplantation for hepatitis B-related end-stage liver disease","volume":"19","author":"Marcellin","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB11|cit11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0025-6196(12)65733-4","article-title":"Failure of interferon to prevent recurrent hepatitis B infection in hepatic allograft","volume":"64","author":"Rakela","year":"1989","journal-title":"Mayo Clin Proc"},{"key":"10.1002\/lt.500020402-BIB12|cit12","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1128\/AAC.33.10.1765","article-title":"Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir]","volume":"33","author":"Vere Hodge","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1002\/lt.500020402-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1128\/AAC.36.12.2747","article-title":"Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus","volume":"36","author":"Earnshaw","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1002\/lt.500020402-BIB14|cit14","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1128\/AAC.38.10.2454","article-title":"Safety of famciclovir in patients with herpes zoster and genital herpes","volume":"38","author":"Saltzman","year":"1994","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"10.1002\/lt.500020402-BIB15|cit15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/jac\/33.1.119","article-title":"Linear pharmacokinetics of penciclovir following administration of single oral doses of famciclovir 125, 250, 500 and 750 mg to healthy volunteers","volume":"33","author":"Pue","year":"1994","journal-title":"J Antimicrob Chemother"},{"key":"10.1002\/lt.500020402-BIB16|cit16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/chir.530050804","article-title":"Use of isotopically chiral [4\u2032-13C]penciclovir and 13C NMR to determine the specificity and absolute configuration of penciclovir phosphate esters formed in HSV-1 and HSV-2 infected cells and by HSV-1-encoded thymidine kinase","volume":"5","author":"Vere Hodge","year":"1993","journal-title":"Chirality"},{"key":"10.1002\/lt.500020402-BIB17|cit17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/jmv.1890420319","article-title":"Oral famciclovir against duck hepatitis B virus replication in hepatic and nonhepatic tissues of ducklings infected in ovo","volume":"42","author":"Tsiquaye","year":"1994","journal-title":"J Med Virol"},{"key":"10.1002\/lt.500020402-BIB18|cit18","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1128\/AAC.38.4.719","article-title":"In vitro antiviral activity of penciclovir, a novel purine nucleoside, against duck hepatitis B virus","volume":"38","author":"Shaw","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1002\/lt.500020402-BIB19|cit19","doi-asserted-by":"crossref","first-page":"329A","DOI":"10.1016\/0270-9139(95)95038-9","article-title":"Inhibitory effect of penciclovir, the active metabolite of famciclovir, on the priming of hepadnavirus reverse transcription (abstract)","volume":"22","author":"Zoulim","year":"1995","journal-title":"Hepatology"},{"issue":"suppl 1","key":"10.1002\/lt.500020402-BIB20|cit20","first-page":"S32A","article-title":"A double-blind, placebo-controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection. (Poster P1C1\/38)","volume":"21","author":"Main","year":"1994","journal-title":"J Hepatol"},{"key":"10.1002\/lt.500020402-BIB21|cit21","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1097\/00007890-199457120-00003","article-title":"Prostaglandin E plus famciclovir-a new concept for the treatment of severe hepatitis B after liver transplantation","volume":"57","author":"B\u00f6ker","year":"1994","journal-title":"Transplantation"},{"key":"10.1002\/lt.500020402-BIB22|cit22","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1136\/gut.37.4.568","article-title":"Clinical relevance of mutations in the precore genome of the hepatitis B virus","volume":"37","author":"Tillmann","year":"1995","journal-title":"Gut"},{"key":"10.1002\/lt.500020402-BIB23|cit23","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1097\/00007890-199457110-00009","article-title":"Should liver transplantation be performed for patients with hepatitis B?","volume":"57","author":"Eason","year":"1994","journal-title":"Transplantation"},{"key":"10.1002\/lt.500020402-BIB24|cit24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/hep.1840220107","article-title":"Effect of immunosuppressive and antiviral agents on hepatitis B virus replication in vitro","volume":"22","author":"McMillan","year":"1995","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB25|cit25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/hep.1840130122","article-title":"Hepatic histological findings after transplantation for chronic hepatitis B virus infection, including a unique pattern of fibrosing cholestatic hepatitis","volume":"13","author":"Davies","year":"1991","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB26|cit26","first-page":"1549","article-title":"Recurrence of hepatitis B after liver transplantation: does hepatitis-B-immunoglobulin modify the recurrent disease?","volume":"22","author":"Mora","year":"1990","journal-title":"Transplant Proc"},{"issue":"1 Pt 2","key":"10.1002\/lt.500020402-BIB27|cit27","first-page":"1492","article-title":"HBV infection after liver transplantation in HBsAg positive patients: experience with long-term immunoprophylaxis","volume":"23","author":"Samuel","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1002\/lt.500020402-BIB28|cit28","first-page":"138A","article-title":"Prophylactic therapy is the most important factor determing recurrence in hepatitis B surface antigen (HBsAg+) patients undergoing liver transplantation (OLT) [Abstract]","volume":"20","author":"Terrault","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB29|cit29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0016-5085(91)90611-N","article-title":"Persistent hepatitis B virus following interferon alfa therapy and liver transplantation","volume":"100","author":"Lavine","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1002\/lt.500020402-BIB30|cit30","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/BF01295916","article-title":"Hepatic HLA antigen display in chronic hepatitis B virus infection. Relation to hepatic expression of HBV genome\/gene products and liver histology","volume":"38","author":"Lau","year":"1993","journal-title":"Dig Dis Sci"},{"key":"10.1002\/lt.500020402-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/hep.1840050612","article-title":"A randomized study of the effects of adenine arabinoside 5\u2032-monophosphate (short or long courses) and lymphoblastoid interferon on hepatitis B virus replication","volume":"5","author":"Lok","year":"1985","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB32|cit32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/gut.26.7.745","article-title":"Randomised controlled trial of adenine arabinoside 5\u2032-monophosphate (ARA-AMP) in chronic hepatitis B virus infection","volume":"26","author":"Weller","year":"1985","journal-title":"Gut"},{"key":"10.1002\/lt.500020402-BIB33|cit33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0168-8278(92)90175-O","article-title":"Failure of acyclovir to enhance the antiviral effect of alpha lymphoblastoid interferon on HBe-seroconversion in chronic hepatitis B. A multicentre randomized controlled trial","volume":"14","author":"Berk","year":"1992","journal-title":"J Hepatol"},{"key":"10.1002\/lt.500020402-BIB34|cit34","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/hep.1840180206","article-title":"Pilot study of ribavirin and interferon-beta for chronic hepatitis B","volume":"18","author":"Kakumu","year":"1993","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB35|cit35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0166-3542(94)90032-9","article-title":"The in vitro anti-hepatitis B virus activity of FIAU [1-(2\u2032-deoxy-2\u2032-fluoro-1-beta-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell","volume":"23","author":"Staschke","year":"1994","journal-title":"Antiviral Res"},{"key":"10.1002\/lt.500020402-BIB36|cit36","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/S0140-6736(94)92599-2","article-title":"Deaths in US fialuridine trial","volume":"343","author":"Brahams","year":"1994","journal-title":"Lancet"},{"key":"10.1002\/lt.500020402-BIB37|cit37","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1056\/NEJM199510263331702","article-title":"Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B","volume":"333","author":"McKenzie","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1002\/lt.500020402-BIB38|cit38","first-page":"209A","article-title":"Mechanisms of FIAU induced hepatotoxicity","volume":"20","author":"Sallie","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB39|cit39","first-page":"199A","article-title":"Double-blind randomized, three month, dose-ranging trial of lamivudine for chronic hepatitis B","volume":"20","author":"Dienstag","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB40|cit40","doi-asserted-by":"crossref","first-page":"112A","DOI":"10.1016\/0270-9139(93)91978-2","article-title":"Phase II trial of lamivudine for chronic hepatitis B","volume":"18","author":"Tyrrel","year":"1993","journal-title":"Hepatology"},{"issue":"1","key":"10.1002\/lt.500020402-BIB41|cit41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.510230101","article-title":"Ganciclovir treatment of hepatitis B virus infection in liver transplant recipients","volume":"23","author":"Gish","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB42|cit42","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1440-1746.1993.tb01527.x","article-title":"Combination antiviral therapy controls severe post-liver transplant recurrence of hepatitis B virus infection","volume":"8","author":"Angus","year":"1993","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1002\/lt.500020402-BIB43|cit43","first-page":"138A","article-title":"Ganciclovir fails to prevent graft rejection following orthotopic liver transplantation for chronic hepatitis B","volume":"20","author":"Jurim","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/lt.500020402-BIB44|cit44","first-page":"430","article-title":"Recurrence of virus B hepatitis after liver transplantation","volume":"16","author":"Gugenheim","year":"1992","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1002\/lt.500020402-BIB45|cit45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00007890-199405820-00009","article-title":"Prostaglandin E in the treatment of recurrent hepatitis B infection after orthotopic liver transplantation","volume":"58","author":"Flowers","year":"1994","journal-title":"Transplantation"}],"container-title":["Liver Transplantation and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.500020402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/lt.500020402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T14:59:09Z","timestamp":1736175549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lt.500020402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,7]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.500020402","relation":{},"ISSN":["1074-3022"],"issn-type":[{"value":"1074-3022","type":"print"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}