{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T05:16:32Z","timestamp":1737782192630,"version":"3.33.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4383,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>\n                           <jats:italic toggle=\"yes\">Abstract<\/jats:italic>\n                        <\/jats:title>\n          <jats:sec>\n            <jats:title>Background &amp; Aims:<\/jats:title>\n            <jats:p>Hepatic myelopathy is a rare complication of chronic liver disease, causing progressive spastic paraparesis. Today, no therapy of this disorder has been established. Commonly used therapeutic strategies for hepatic encephalopathy aiming at the reduction of plasma ammonia levels such as protein restriction, oral neomycin, lactulose, or ornithine aspartate fail to improve the symptoms of hepatic myelopathy. The aim of this study was to find out whether orthotopic liver transplantation (OLT) may improve hepatic myelopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Follow-up examinations of 3 patients with severe hepatic myelopathy before and after OLT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>In all 3 patients, the neurologic status improved significantly after liver transplantation. The grade of improvement was related to the time interval between onset of the first symptoms of hepatic myelopathy and liver transplantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Early recognition of hepatic myelopathy is important because timely liver transplantation as an established therapy for end-stage liver disease offers the chance of complete recovery from hepatic paraparesis. (<jats:italic toggle=\"yes\">Gastroenterology 2003;124:346-351.<\/jats:italic>)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.500090917","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T17:31:30Z","timestamp":1277227890000},"page":"995-996","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Hepatorenal syndrome, hepatopulmonary syndrome, and now, hepatospinal syndrome?"],"prefix":"10.1097","volume":"9","author":[{"given":"Vincent G.","family":"Bain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/lt.500090917-BIB1|cit1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1053\/jhep.2002.34343","article-title":"Effects of noradrenalin and albumin in patients with type 1 hepatorenal syndrome: A pilot study","volume":"36","author":"Duvoux","year":"2002","journal-title":"Hepatology"},{"key":"10.1002\/lt.500090917-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/hep.510290629","article-title":"Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide","volume":"29","author":"Angeli","year":"1999","journal-title":"Hepatology"},{"key":"10.1002\/lt.500090917-BIB3|cit3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.7326\/0003-4819-122-7-199504010-00008","article-title":"The hepatopulmonary syndrome","volume":"122","author":"Lange","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1002\/lt.500090917-BIB4|cit4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000117040","article-title":"Hepatic myelopathy: A rare complication of portacaval shunt","volume":"34","author":"Mendoza","year":"1994","journal-title":"Eur Neurol"},{"key":"10.1002\/lt.500090917-BIB5|cit5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF00710238","article-title":"Degeneration of the cortico-spinal tract following portosystemic shunt associated with spinal cord infarction","volume":"406","author":"Giangaspero","year":"1985","journal-title":"Virchows Arch"},{"key":"10.1002\/lt.500090917-BIB6|cit6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/00004836-199110000-00018","article-title":"Postshunt myelopathy","volume":"13","author":"Bain","year":"1991","journal-title":"J Clin Gastroenterol"},{"key":"10.1002\/lt.500090917-BIB7|cit7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1053\/gast.2003.50062","article-title":"Liver transplantation improves hepatic myelopathy: Evidence by three cases","volume":"124","author":"Weissenborn","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1002\/lt.500090917-BIB8|cit8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJM199901143400216","article-title":"Improvement of hepatic myelopathy after liver transplantation","volume":"340","author":"Troisi","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1002\/lt.500090917-BIB9|cit9","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/jnnp.60.5.590","article-title":"Failure of presumed hepatic myelopathy to improve after liver transplantation","volume":"60","author":"Counsell","year":"1996","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.500090917","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200309000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T15:06:04Z","timestamp":1737731164000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200309000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.500090917","relation":{},"ISSN":["1527-6465"],"issn-type":[{"type":"print","value":"1527-6465"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}