{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:02:07Z","timestamp":1791093727208,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T00:00:00Z","timestamp":1157932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2006,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Summary:<\/jats:bold> The preparation of mono\u2010 and multifilament sutures incorporating ibuprofen as an anti\u2010inflammatory agent is considered. Poly(<jats:italic>p<\/jats:italic>\u2010dioxanone) monofilament samples can be loaded by a molecular diffusion process using a swelling agent such as dichloromethane. The mechanical properties have been measured and have not shown a significant change for the ibuprofen loaded samples in knot tensile assays. The kinetics of both the loading process and the release in a S\u00f6rensen's medium at 37\u2009\u00b0C have been investigated. Diffusion coefficients have also been estimated from film and slab poly(<jats:italic>p<\/jats:italic>\u2010dioxanone) samples containing ibuprofen and their release behavior compared to that shown by monofilaments. Release from a coating copolymer based on lactide, <jats:italic>\u03b5<\/jats:italic>\u2010caprolactone and trimethylene carbonate (PLA\/PCA\/PTMC 10\/60\/30) has also been studied. This coating solubilizes ibuprofen molecules well and can be used for braided sutures or when a rapid dose of ibuprofen is preferred.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/jpeg\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mgra001.jpg\"><jats:alt-text>magnified image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p>","DOI":"10.1002\/mabi.200600084","type":"journal-article","created":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T18:36:14Z","timestamp":1157999774000},"page":"767-775","source":"Crossref","is-referenced-by-count":60,"title":["Loading and Release of Ibuprofen in Multi\u2010 and Monofilament Surgical Sutures"],"prefix":"10.1002","volume":"6","author":[{"given":"Ra\u00fcl","family":"Zurita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Puiggal\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Rodr\u00edguez\u2010Gal\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,28]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1089\/10962960260496361"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200500147"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(84)80022-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90712-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1994.tb02823.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1997.130-az0126.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018969506143"},{"key":"e_1_2_6_8_2","volume-title":"Sustained Release Patents Using Carbomer Resins","author":"Goodrich B. 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