{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:26:10Z","timestamp":1768821970925,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T00:00:00Z","timestamp":1237161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2009,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Highly branched cyclic dextrin derivatives (CH\u2010CDex) that are partly substituted with cholesterol groups have been synthesized. The CH\u2010CDex forms monodisperse and stable nanogels with a hydrodynamic radii of \u224810 nm by the self\u2010assembly of 4\u20136 CH\u2010CDex macromolecules in water. The CH\u2010CDex nanogels spontaneously trap 10\u201316 molecules of fluorescein isothiocyanate\u2010labeled insulin (FITC\u2010Ins). The complex shows high colloidal stability: no dissociation of trapped insulin is observed after at least 1 month in phosphate buffer (0.1 <jats:sc>M<\/jats:sc>, pH 8.0). In the presence of bovine serum albumin (BSA, 50 mg\u2009\u00b7\u2009mL<jats:sup>\u22121<\/jats:sup>), which is a model blood system, the FITC\u2010Ins trapped in the nanogels is continuously released (\u224820% at 12 h) without burst release. The high\u2010density nanogel structure derived from the highly branched CDex significantly affects the stability of the nanogel\u2013protein complex.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/jpeg\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mgra001.jpg\"><jats:alt-text>magnified image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p>","DOI":"10.1002\/mabi.200800288","type":"journal-article","created":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T06:29:30Z","timestamp":1237184970000},"page":"694-701","source":"Crossref","is-referenced-by-count":30,"title":["Self\u2010Assembled Nanogel of Hydrophobized Dendritic Dextrin for Protein Delivery"],"prefix":"10.1002","volume":"9","author":[{"given":"Yayoi","family":"Ozawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichi","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Akiyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-1669(97)80065-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.051956206"},{"key":"e_1_2_6_4_2","unstructured":"\u00a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2008.01.002"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd818"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1201-1173"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(99)00066-X"},{"key":"e_1_2_6_9_2","unstructured":"\u00a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2007.04.001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200501321"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja010609f"},{"key":"e_1_2_6_13_2","unstructured":"\u00a0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/la015758q"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma0120005"},{"key":"e_1_2_6_16_2","unstructured":"\u00a0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma00064a011"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm070136q"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma960786e"},{"key":"e_1_2_6_20_2","first-page":"286","volume":"42","author":"Akiyoshi K.","year":"1996","journal-title":"Eur. J. Pharm. Biopharm"},{"key":"e_1_2_6_21_2","unstructured":"\u00a0"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja953843c"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma00104a021"},{"key":"e_1_2_6_24_2","unstructured":"\u00a0"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2007.11.003"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm049501t"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc9801272"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)01028-7"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(94)90118-X"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc700422s"},{"key":"e_1_2_6_31_2","unstructured":"\u00a0"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3717"},{"key":"e_1_2_6_33_2","first-page":"3385","volume":"5","author":"Gu X. G.","year":"1998","journal-title":"Cancer Res."},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00705.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1546"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.12.112"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(96)90126-3"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1678153"},{"key":"e_1_2_6_39_2","volume-title":"Surfactant Solutions: New Methods of Investigation","author":"Zana R.","year":"1987"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00486a062"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00449a004"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/j100581a008"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00563a017"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.200800288","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.200800288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T18:28:16Z","timestamp":1695925696000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.200800288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7,7]]}},"alternative-id":["10.1002\/mabi.200800288"],"URL":"https:\/\/doi.org\/10.1002\/mabi.200800288","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}