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In this study, the complexation between PAA and MC is explored in dilute aqueous solutions under acidic conditions. The formation of stable nanoparticles is established, whose size and colloidal stability are greatly dependent on solution pH and polymers ratio in the mixture. Poly(acrylic acid) and methylcellulose are also used to prepare polymeric films by casting from aqueous solutions. It is established that uniform films can be prepared by casting from polymer mixture solutions at pH 3.4\u20134.5. At lower pHs (pH\u2009&lt;\u20093.0) the films have inhomogeneous morphology resulting from strong interpolymer complexation and precipitation of polycomplexes, whereas at higher pHs (pH 8.3) the polymers form fully immiscible blends because of the lack of interpolymer hydrogen\u2010bonding. The PAA\/MC films cast at pH 4 are shown to be non\u2010irritant to mucosal surfaces. These films provide a platform for ocular formulation of riboflavin, a drug used for corneal cross\u2010linking in the treatment of keratoconus. An in vitro release of riboflavin as well as an in vivo retention of the films on corneal surfaces can be controlled by adjusting PAA\/MC ratio in the formulations.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mabi201300313-gra-0001.png\" xlink:title=\"mabi201300313-gra-0001\"\/><\/jats:p><\/jats:sec>","DOI":"10.1002\/mabi.201300313","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T14:58:34Z","timestamp":1381244314000},"page":"225-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Hydrogen\u2010Bonded Complexes and Blends of Poly(acrylic acid) and Methylcellulose: Nanoparticles and Mucoadhesive Films for Ocular Delivery of Riboflavin"],"prefix":"10.1002","volume":"14","author":[{"given":"Olga V.","family":"Khutoryanskaya","sequence":"first","affiliation":[{"name":"School of Pharmacy University of Reading Whiteknights, PO Box 224, Reading RG6 6AD Berkshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W. 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