{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:43:42Z","timestamp":1777517022319,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["91027040"],"award-info":[{"award-number":["91027040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21004042"],"award-info":[{"award-number":["21004042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21374069"],"award-info":[{"award-number":["21374069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21074083"],"award-info":[{"award-number":["21074083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21104051"],"award-info":[{"award-number":["21104051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Scientific Project of China","award":["#2011CB933501"],"award-info":[{"award-number":["#2011CB933501"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>One\u2010pot system combining multi\u2010reactions is used to synthesize novel porphyrin\u2010glycopolymer conjugates. Sodium mercury amalgam is used to catalyze the reactions: 1) reduction of RAFT polymerized poly(2\u2010(methacrylamido) glucopyranose) (PMAG), 2) converting protoporphyrin to protoporphyrinogen, 3) thiol\u2010ene coupling reaction of PMAG and protoporphyrinogen. The product is oxidized in the same pot to generate the final porphyrin\u2010PMAG conjugates. The resulting conjugates are characterized by NMR, GPC, UV\u2010Vis, and fluorescence spectroscopy. Glycoparticles (\u2248200\u2009nm) bearing glucose units are formed by dissolving the conjugates in water. Glycoparticles show enhanced binding ability toward Con A, bind K562 cells efficiently and kill these cells under light irradiation in dose and light treatment length dependent manners, illustrating the potential biological applications of the conjugates as photosensitizer for cancer imaging and photodynamic therapy.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mabi201300451-gra-0001.png\" xlink:title=\"mabi201300451-gra-0001\"\/><\/jats:p><\/jats:sec>","DOI":"10.1002\/mabi.201300451","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T12:57:43Z","timestamp":1385557063000},"page":"340-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["One\u2010<scp>P<\/scp>ot Synthesis of Glycopolymer\u2010<scp>P<\/scp>orphyrin Conjugate as Photosensitizer for Targeted Cancer Imaging and Photodynamic Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Jiawei","family":"Lu","sequence":"first","affiliation":[{"name":"Center for Soft Condensed Matter Physics and Interdisciplinary Research Soochow University Suzhou 215006 P. R. China"},{"name":"Department of Polymer Science and Engineering, College of Chemistry Chemical Engineering and Materials Science, Soochow University Suzhou 215123 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Soft Condensed Matter Physics and Interdisciplinary Research Soochow University Suzhou 215006 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Polymer Science and Engineering, College of Chemistry Chemical Engineering and Materials Science, Soochow University Suzhou 215123 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Cyrus Tang Hematology Center Soochow University Suzhou 215123 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Soft Condensed Matter Physics and Interdisciplinary Research Soochow University Suzhou 215006 P. R. China"},{"name":"Department of Polymer Science and Engineering, College of Chemistry Chemical Engineering and Materials Science, Soochow University Suzhou 215123 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"Center for Soft Condensed Matter Physics and Interdisciplinary Research Soochow University Suzhou 215006 P. R. China"},{"name":"Department of Polymer Science and Engineering, College of Chemistry Chemical Engineering and Materials Science, Soochow University Suzhou 215123 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Cyrus Tang Hematology Center Soochow University Suzhou 215123 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaojian","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Soft Condensed Matter Physics and Interdisciplinary Research Soochow University Suzhou 215006 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.07.014"},{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr900236h"},{"key":"e_1_2_5_1_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.01.004"},{"key":"e_1_2_5_1_4","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22016"},{"key":"e_1_2_5_1_5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3011014"},{"key":"e_1_2_5_1_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2008.07.007"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201103557"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201200742"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/cs9952400019"},{"key":"e_1_2_5_4_1","first-page":"1180","volume":"59","author":"Berg K.","year":"1999","journal-title":"Cancer Res."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.08.016"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb22372.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202064"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm061415j"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200502794"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201200222"},{"key":"e_1_2_5_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201200055"},{"key":"e_1_2_5_7_4","doi-asserted-by":"publisher","DOI":"10.1039\/c0py00141d"},{"key":"e_1_2_5_7_5","doi-asserted-by":"publisher","DOI":"10.1039\/C0PY00149J"},{"key":"e_1_2_5_7_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2003.10.019"},{"key":"e_1_2_5_7_7","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2013.06.025"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-009-9998-8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200903924"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/B9PY00216B"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja8006325"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/b900215d"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/b813438c"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/b906865a"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(01)00255-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64262-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0930270"},{"key":"e_1_2_5_13_3","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.768"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma300218n"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/mz300081d"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma301288m"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1016\/S0021-9258(18)69774-1","volume":"234","author":"Chu T. C.","year":"1959","journal-title":"J. Biol. Chem."},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac60067a046"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp202436x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma062562u"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503575"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2py20668d"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma1004937"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja058364k"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja016727k"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2012.12.004"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02428.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-6030(01)00409-9"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1999.tb08240.x"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201300451","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201300451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.201300451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:12:13Z","timestamp":1696399933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201300451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,27]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/mabi.201300451"],"URL":"https:\/\/doi.org\/10.1002\/mabi.201300451","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,27]]}}}