{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:51:42Z","timestamp":1788191502680,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81202482"],"award-info":[{"award-number":["81202482"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This work deals with the synthesis of insulin loaded nanoparticles (NPs) composed of thiolated Eudragit L100 (Eul\u2010cys) and reduced glutathione (GSH) as potential nanocarriers for oral delivery of insulin. Perfectly spherical NPs with an average particle size of nearly 200\u2013300\u2009nm are prepared. The insulin release from Eul\u2010cys\/GSH and Eul\u2010cys NPs in PBS (pH 7.4) shows that GSH can slightly decrease the release rate of insulin. Eul\u2010cys in combination with GSH or sodium caprate (SC) is evaluated for its permeation enhancing effect of FITC\u2010insulin using the Caco\u20102 monolayer and Caco\u20102\/HT29\u2010MTX co\u2010cultured cells models. SC results in greater permeation enhancement compared to GSH. However, GSH proves to be less toxic. Paracellular transport of insulin represents the main mechanism by which the NPs facilitate insulin permeation through the intestinal epithelium, whereas a number of NPs are also taken up by the cells and release insulin within the cells.\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mabi201300515-gra-0001.png\" xlink:title=\"mabi201300515-gra-0001\"\/>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mabi.201300515","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T10:06:47Z","timestamp":1397642807000},"page":"842-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Thiolated Eudragit\u2010based Nanoparticles for Oral Insulin Delivery: Preparation, Characterization, and Evaluation Using Intestinal Epithelial Cells In Vitro"],"prefix":"10.1002","volume":"14","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics Shenyang Pharmaceutical University Shenyang 110016 China"},{"name":"Normal College Shenyang University Shenyang 110044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuli","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Shenyang Pharmaceutical University Shenyang 110016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Shenyang Pharmaceutical University Shenyang 110016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Shenyang Pharmaceutical University Shenyang 110016 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