{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:50:11Z","timestamp":1791647411856,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Mucus forms a protective hydrogel layer over the intestinal epithelium, presenting a selective and robust barrier to the uptake of particulates and microbe invasion. Disease can alter mucus production and composition, thus potentially modifying mucosal barrier properties. Hirschsprung's disease (HD) is a developmental abnormality of the nervous system often complicated by intestinal infection. An investigation of colonic mucus barrier properties in an HD animal model, endothelin receptor B mutant mice, revealed significantly reduced microsphere (passive) and microbe (active) transport rates (7\u2010fold and 3.6\u2010fold, respectively, in proximal colonic mucus) relative to wild\u2010type. Transport differences were evident in both the ganglionic and aganglionic colon segments, in agreement with the risk of HD\u2010associated enterocolitis after surgery to remove aganglionic colon segments. The development of therapies aimed at altering colonic mucus barrier properties could be explored towards preventing the onset of enterocolitis in HD.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mabi201400473-gra-0001.png\" xlink:title=\"mabi201400473-gra-0001\"\/><\/jats:p><\/jats:sec>","DOI":"10.1002\/mabi.201400473","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T20:22:52Z","timestamp":1422908572000},"page":"712-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Mucus Barriers to Microparticles and Microbes are Altered in Hirschsprung's Disease"],"prefix":"10.1002","volume":"15","author":[{"given":"Hasan M.","family":"Yildiz","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering Northeastern University Boston Massachusetts 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor L.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Northeastern University Boston Massachusetts 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan M.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Massachusetts General Hospital Boston Massachusetts 02114 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Carrier","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Northeastern University Boston Massachusetts 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"2","volume":"61","author":"Cone R. A.","year":"2009","journal-title":"Adv. Drug Deliver. Rev"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200900107"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31826ae849"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.11.002"},{"key":"e_1_2_7_5_1","first-page":"2","volume":"63","author":"Johansson M. E. V.","year":"2013","journal-title":"Gut"},{"key":"e_1_2_7_6_1","first-page":"1","volume":"53","author":"Burkardt D. D. C.","year":"2013","journal-title":"Clin. Pediatr. (Phila.)"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.4.436"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-005-1551-1"},{"key":"e_1_2_7_9_1","first-page":"12","volume":"24","author":"Teitelbaum D. H.","year":"1989","journal-title":"J. Pediatr. Surg"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90683-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90372-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90202-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.4.589"},{"key":"e_1_2_7_14_1","volume-title":"Hirschsprung's Disease and Allied Disorders","author":"Puri P.","year":"2008"},{"key":"e_1_2_7_15_1","first-page":"50","volume":"278","author":"Dawson M.","year":"2003","journal-title":"J. Biol. Chem"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/bp0342553"},{"key":"e_1_2_7_17_1","first-page":"50","volume":"47","author":"Wang Y. Y.","year":"2008","journal-title":"Angew. Chem. Int. Ed"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610198103"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0636277100"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.08.001"},{"key":"e_1_2_7_21_1","first-page":"3","volume":"232","author":"Suk J. S.","year":"2007","journal-title":"Exp. Biol. Med"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2005.06.002"},{"key":"e_1_2_7_23_1","first-page":"6","volume":"6","author":"Jachak A.","year":"2011","journal-title":"Nanotoxicology"},{"key":"e_1_2_7_24_1","first-page":"46","volume":"106","author":"Tang B.","year":"2009","journal-title":"PNAS"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194238"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033796"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(91)90287-X"},{"key":"e_1_2_7_28_1","first-page":"8","volume":"8","author":"Schreiber O.","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.1.4.12778"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6017(200007)89:7<835::AID-JPS1>3.0.CO;2-6"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00832247"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(03)00376-2"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(88)80730-9"},{"key":"e_1_2_7_34_1","unstructured":"M.Speare University of London. Jan 2011."}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201400473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201400473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.201400473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:58:10Z","timestamp":1696370290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201400473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,2]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/mabi.201400473"],"URL":"https:\/\/doi.org\/10.1002\/mabi.201400473","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,2]]}}}