{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:38:57Z","timestamp":1790483937448,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"COOPERLINK-2011 MIUR"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>\n                    The design of 3D scaffolds is a crucial step in the field of regenerative medicine. Scaffolds should be degradable and bioresorbable as well as display good porosity, interconnecting pores, and topographic features; these properties favour tissue integration and vascularization. These requirements could be fulfilled by hybrid hydrogels using a combination of natural and synthetic components. Here, the mechanical and biological properties of a polyethylene glycol\u2010fibrinogen hydrogel (PFHy) are improved in order to favour the proliferation and differentiation of human Sca\u20101\n                    <jats:sup>pos<\/jats:sup>\n                    cardiac progenitor cells (hCPCs). PFHys are modified by embedding air\u2010 or perfluorohexane\u2010filled bovine serum albumin microbubbles (MBs) and characterized. Changes in cell morphology are observed in MBs\u2013PFHys, suggesting that MBs could enhance the formation of bundles of cells and influence the direction of the spindle growth. The properties of MBs as carriers of active macromolecules are also exploited. For the first time, enzyme\u2010coated MBs have been used as systems for the production of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S)\u2010releasing scaffolds. Novel H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing PFHys are produced, which are able to improve the growth of hCPCs. This novel 3D cell\u2013scaffold system will allow the assessment of the effects of H\n                    <jats:sub>2<\/jats:sub>\n                    S on the cardiac muscle regeneration with its potential applications in tissue repair.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mabi201500430-abs-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1002\/mabi.201500430","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T06:21:21Z","timestamp":1454998881000},"page":"847-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Design of a Novel Composite H\n                    <sub>2<\/sub>\n                    S\u2010Releasing Hydrogel for Cardiac Tissue Repair"],"prefix":"10.1002","volume":"16","author":[{"given":"Arianna","family":"Mauretti","sequence":"first","affiliation":[{"name":"Department of Sciences and Chemical Technologies University of Rome Tor Vergata  Via della Ricerca Scientifica 00133 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Neri","sequence":"additional","affiliation":[{"name":"Department of Sciences and Chemical Technologies University of Rome Tor Vergata  Via della Ricerca Scientifica 00133 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kossover","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Technion\u2010Israel Institute of Technology  Haifa 32000 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Seliktar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Technion\u2010Israel Institute of Technology  Haifa 32000 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Di","family":"Nardo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine University of Rome Tor Vergata  Via Montpellier 1 00133 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Melino","sequence":"additional","affiliation":[{"name":"Department of Sciences and Chemical Technologies University of Rome Tor Vergata  Via della Ricerca Scientifica 00133 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-chembioeng-061010-114257"},{"key":"e_1_2_6_2_1","first-page":"p. 235","volume-title":"Tissue Engineering","author":"Santos A. 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