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P((MAA\u2010<jats:italic>co<\/jats:italic>\u2010NVP)\u2010g\u2010EG) hydrogels are synthesized with PEG\u2010based cross\u2010linking agents of varying length and incorporation densities. The composition is confirmed using FT\u2010IR spectroscopy and shows peak shifts indicating hydrogen bonding. Scanning electron microscopy reveals microparticles with an irregular, planar morphology. The pH\u2010responsive behavior of the hydrogels is confirmed under equilibrium and dynamic conditions, with the hydrogel collapsed at acidic pH and swollen at neutral pH. The ability of the hydrogels to partition model protein therapeutics at varying pH and ionic strength is evaluated using three model proteins: insulin, porcine growth hormone, and ovalbumin. 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