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Lack of suitable surface which promotes growth of both osteogenic and nonosteogenic cells is a major limitation. Here a novel biomaterial is reported that is synthesized from natural polysaccharide, namely, tamarind kernel polysaccharide (TKP), which is grafted with hydrophilic acrylic acid (AA) by radical polymerization. Modification in surface functionality removes unwanted proteins and alters hydrophilic\/hydrophobic balance. TKP\u2010AA is suitable for the growth of different nonosteogenic and osteogenic cells. This material is suitable for osteoblasts and promotes in vitro mineralization and differentiation without the addition of exogenous growth factors. TKP\u2010AA can be used for the growth of mesenchymal stem cell\u2010derived osteoblasts. It is suggested that TKP\u2010AA can potentially be used as a scaffold for diverse cell types and particularly for bone tissue engineering at low cost.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mabi201600268-abs-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/mabi.201600268","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T11:01:13Z","timestamp":1477047673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Modified Polysaccharide\u2010Based Hydrogel for Enhanced Osteogenic Maturation and Mineralization Independent of Differentiation Factors"],"prefix":"10.1002","volume":"17","author":[{"given":"Sridhar","family":"Sanyasi","sequence":"first","affiliation":[{"name":"School of Biotechnology KIIT University  Bhubaneswar 751024 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Biotechnology KIIT University  Bhubaneswar 751024 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arijit","family":"Ghosh","sequence":"additional","affiliation":[{"name":"School of Biological Sciences NISER  Bhubaneswar 751024 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh Kumar","family":"Majhi","sequence":"additional","affiliation":[{"name":"School of Biological Sciences NISER  Bhubaneswar 751024 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navneet","family":"Kaur","sequence":"additional","affiliation":[{"name":"School of Biotechnology KIIT University  Bhubaneswar 751024 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Choudhury","sequence":"additional","affiliation":[{"name":"School of Biotechnology KIIT University  Bhubaneswar 751024 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udai P.","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Electronics Engineering KIIT University  Bhubaneswar 751024 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandan","family":"Goswami","sequence":"additional","affiliation":[{"name":"School of Biological Sciences NISER  Bhubaneswar 751024 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luna","family":"Goswami","sequence":"additional","affiliation":[{"name":"School of Biotechnology KIIT University  Bhubaneswar 751024 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/1616-5195(20020201)2:2<67::AID-MABI67>3.0.CO;2-F"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2012.0012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-9-18"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493529"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200802106"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2447"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.01.016"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.05.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v40.i5.10"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201200409"},{"key":"e_1_2_6_11_1","first-page":"361382","volume":"2012","author":"Arvind S. 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