{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:00:04Z","timestamp":1753869604400,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 104\u20102628\u2010E\u2010002\u2010010\u2010MY3","MOST 101\u20102628\u2010E\u2010002\u2010034\u2010MY3"],"award-info":[{"award-number":["MOST 104\u20102628\u2010E\u2010002\u2010010\u2010MY3","MOST 101\u20102628\u2010E\u2010002\u2010034\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["102R7745","103R7745"],"award-info":[{"award-number":["102R7745","103R7745"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 104-2628-E-002-010-MY3","MOST 101-2628-E-002-034-MY3"],"award-info":[{"award-number":["MOST 104-2628-E-002-010-MY3","MOST 101-2628-E-002-034-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["102R7745","103R7745"],"award-info":[{"award-number":["102R7745","103R7745"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>A multicomponent functional polymer is synthesized to support specific reactivity for successful conjugation with the vast array of functionality present in biological systems and the flexibility to conjugate biomolecules without requiring additional modification to install a terminal functional group. The multifunctional surface is realized using a novel coating composed of distinct <jats:italic>N<\/jats:italic>\u2010hydroxysuccinimide (NHS) ester and benzoyl functionalities, which can provide accessibility to both the NHS ester\u2010amine coupling reaction and the photochemically induced benzophenone crosslinking reaction, respectively. In addition, the multifunctional polymer is fabricated and transformed to form nanoscale colloids through the solvent displacement of a water\/DMF system due to solubility characteristics of the resulting polymer with high polarity. A facile and efficient fabrication approach using the multifunctional nanocolloid is thus demonstrated to create a drug carrier by installing paclitaxel and folic acid for targeted cancer therapy.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mabi201600322-abs-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/mabi.201600322","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T11:32:58Z","timestamp":1477567978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface"],"prefix":"10.1002","volume":"17","author":[{"given":"Ruei\u2010Hung","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsing\u2010Ying","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Pin","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Jye","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chih","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital  Taipei 10048 Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsien\u2010Yeh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei 10617 Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08601"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-chembioeng-060713-040042"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200900942"},{"volume-title":"Bioconjugate Techniques","year":"2008","author":"Hermanson G. T.","key":"e_1_2_6_4_1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305627"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/la0016930"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201303050"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc41491d"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201200011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja108679m"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200600357"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.5b02433"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200602830"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja057082h"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000036917.75634.be"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.12.022"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pol.1966.150041209"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1520\/D3359\u201009E02"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.06.088"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5BM00127G"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB00992D"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19991008)83:2<151::AID-IJC1>3.0.CO;2-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar7000815"},{"key":"e_1_2_6_24_1","first-page":"281","volume":"8","author":"Sharma D.","year":"1996","journal-title":"Oncol. Res."},{"key":"e_1_2_6_25_1","first-page":"4129","volume":"59","author":"Monsky W. L.","year":"1999","journal-title":"Cancer Res."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61737-960-4"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201600322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201600322","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.201600322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:36:14Z","timestamp":1696329374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201600322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/mabi.201600322"],"URL":"https:\/\/doi.org\/10.1002\/mabi.201600322","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"type":"print","value":"1616-5187"},{"type":"electronic","value":"1616-5195"}],"subject":[],"published":{"date-parts":[[2016,10,27]]},"article-number":"1600322"}}