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Commercially available conjugates employ poly(ethylene glycol) (PEG) as the protective polymer; however, PEG has a number of shortcomings, including non\u2010biodegradability and immunogenicity, that call for the development of alternatives. Here, the synthesis of biodegradable poly(phosphate), that is, poly(ethyl ethylene phosphate) (PEEP), by organo\u2010catalyzed anionic ring\u2010opening polymerization exhibiting dispersity values\n                    <jats:italic>\u00d0<\/jats:italic>\n                    &lt; 1.3 is reported. Polymers with molecular weights between 2000 and 33\u2009200 g mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    are then \u03c9\u2010functionalized with a succinimidyl carbonate group and subsequently conjugated to model proteins. These are the first conjugates based on polyphosphates which degraded upon exposure to phosphodiesterase. As is the case for PEGylated therapeutics, residual in vitro activity of the PPEylated conjugates depends on the extent of protein modification. These results suggest that PEEP exhibits the desired properties of a biopolymer for use in next generation, fully degradable drug delivery systems.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mabi201600377-abs-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1002\/mabi.201600377","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T09:32:52Z","timestamp":1481535172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Reversible Bioconjugation: Biodegradable Poly(phosphate)\u2010Protein Conjugates"],"prefix":"10.1002","volume":"17","author":[{"given":"Tobias","family":"Steinbach","sequence":"first","affiliation":[{"name":"Max\u2010Planck\u2010Institut f\u00fcr Polymerforschung  Ackermannweg 10 55128 Mainz Germany"},{"name":"Graduate School Material Science in Mainz  Staudinger Weg 9 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Becker","sequence":"additional","affiliation":[{"name":"Max\u2010Planck\u2010Institut f\u00fcr Polymerforschung  Ackermannweg 10 55128 Mainz Germany"},{"name":"Graduate School Material Science in Mainz  Staudinger Weg 9 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Spiegel","sequence":"additional","affiliation":[{"name":"Max\u2010Planck\u2010Institut f\u00fcr Polymerforschung  Ackermannweg 10 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamiris","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"CNR Istituto Officina dei Materiali c\/o Institut Laue Langevin  38000 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Russo","sequence":"additional","affiliation":[{"name":"CNR Istituto Officina dei Materiali c\/o Institut Laue Langevin  38000 Grenoble France"},{"name":"Institut Lumi\u00e8re Mati\u00e8re  Universit\u00e9 de Lyon 1 69622 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik R.","family":"Wurm","sequence":"additional","affiliation":[{"name":"Max\u2010Planck\u2010Institut f\u00fcr Polymerforschung  Ackermannweg 10 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,12]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja504390x"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1py00034a"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.01.042"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.08.276"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623315591171"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0py00406e"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.02.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2015.08.009"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527644827.ch7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01168a032"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201500147"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b01269"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2015.330"},{"key":"e_1_2_6_14_1","first-page":"1828","author":"Edmundson R. 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