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Antibiotics are commonly used against <jats:italic>P. acnes<\/jats:italic> but buildup of resistance is well\u2010known. Worse, antibiotic regimens build up resistance for more sensitive bacteria such as <jats:italic>Staphylococcus epidermidis<\/jats:italic>. The polycation AMP mimic C12\u201050, <jats:bold>1<\/jats:bold>, is chosen for the present study as it has been previously shown to have high antimicrobial effectiveness. This study reports that C12\u201050 is active against <jats:italic>P. acnes<\/jats:italic> (strain ATCC 6919) with a minimum inhibitory concentration (MIC) of 6.3 \u00b5g mL<jats:sup>\u22121<\/jats:sup>. To monitor resistance build\u2010up ten passages are conducted with C12\u201050 against <jats:italic>P. acnes<\/jats:italic>. The MIC remains constant with no resistance buildup. Parallel studies with erythromycin confirm previously reported resistance buildup. 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