{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:31:50Z","timestamp":1789810310784,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Periodontitis treatments usually require local administration of antimicrobial drugs with the aim to reduce the bacterial load inside the periodontal pocket. Effective pharmaceutical treatments may require sustained local drug release for several days in the site of interest. Currently available solutions are still not able to fulfill the clinical need for high\u2010quality treatments, mainly in terms of release profiles and patients' comfort. This work aims to fill this gap through the development of an in situ gelling system, capable to achieve controlled and sustained release of antimicrobial agents for medium\u2010to\u2010long\u2010term treatments. The system is composed of micrometer\u2010sized \u03b2\u2010cyclodextrin\u2010based hydrogel (bCD\u2010Jef\u2010MPs), featured by a strong hydrophilic character, suspended in a synthetic block\u2010co\u2010polymer solution (Poloxamer 407), which is capable to undergo rapid thermally induced sol\u2013gel phase transition at body temperature. The chemical structure of bCD\u2010Jef\u2010MPs was confirmed by cross\u2010correlating data from Fourier transform infrared (FTIR) spectroscopy, swelling test, and degradation kinetics. The thermally induced sol\u2013gel phase transition is demonstrated by rheometric tests. The effectiveness of the described system to achieve sustained release of antimicrobial agents is demonstrated in vitro, using chlorhexidine digluconate as a drug model. The results achieved in this work disclose the potential of the mentioned system in effectively treating periodontitis lesions.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mabi201700103-abs-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/mabi.201700103","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T17:38:37Z","timestamp":1493746717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["An Injectable System for Local and Sustained Release of Antimicrobial Agents in the Periodontal Pocket"],"prefix":"10.1002","volume":"17","author":[{"given":"Laura","family":"Morelli","sequence":"first","affiliation":[{"name":"Filarete Foundation  Viale Ortles 22\/4 20139 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martino Alfredo","family":"Cappelluti","sequence":"additional","affiliation":[{"name":"SEMM\u2013European School of Molecular Medicine Campus IFOM\u2010IEO  via Adamello 16 20139 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Ricotti","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute Scuola Superiore Sant'Anna  viale R. Piaggio 34 56025 Pontedera Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Lenardi","sequence":"additional","affiliation":[{"name":"Filarete Foundation  Viale Ortles 22\/4 20139 Milano Italy"},{"name":"CIMAINA and Dipartimento di Fisica Universit\u00e0 degli Studi di Milano  via Celoria 16 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irini","family":"Gerges","sequence":"additional","affiliation":[{"name":"Tensive S.r.l.  Via Timavo 34 20124 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"key":"e_1_2_6_1_1","first-page":"62","volume-title":"Bacterial Adherence","author":"Gibbons R. J.","year":"1980"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2187"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800101301"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics3030538"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.50.63"},{"key":"e_1_2_6_6_1","first-page":"66","volume":"4","author":"Chhina K.","year":"2012","journal-title":"Indian J. Dental. Sci."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050216"},{"key":"e_1_2_6_8_1","unstructured":"S. R.Venkatram I.Yue R. S.Langer US Patent No. 6 582 717 2003."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5138\/ijdd.2009.0975.0215.01001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-010-4098-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2014.06.021"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.02.016"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30769"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2007.05.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2003.07245.x"},{"key":"e_1_2_6_16_1","unstructured":"V. R.Shastri I.Yue P.Hildgen R. D.Sinisterra R. S.Langer US Patent No. 20 030 078 215 2003."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-010-9765-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2478\/acph-2013-0021","volume":"63","author":"Gursalkar T.","year":"2013","journal-title":"Acta Pharm."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(98)00337-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3935(19990701)200:7<1644::AID-MACP1644>3.0.CO;2-P"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde.11.140"},{"key":"e_1_2_6_22_1","unstructured":"The Biopharmaceutics Classification System (BCS) Guidance according to FDA.http:\/\/www.fda.gov\/AboutFDA\/CentersOffices\/OfficeofMedicalProductsandTobacco\/CDER\/ucm128219.htm(accessed: October 2016)."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.06.058"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2013.09.006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.05.001"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.09.113"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639049709148496"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.02.011"},{"key":"e_1_2_6_29_1","unstructured":"D. G. A.Nelson C. J.Sheehan US Patent No. 6 942 848 2005."},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012788432106"},{"key":"e_1_2_6_31_1","unstructured":"G.Gilardi F.Trotta R.Cavalli P.Ferruti E.Ranucci G.Di Nardo C.Roggero V.Tumiatti International Patent Application No. WO2009149883 A1 17 2009."},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21310"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328212446097"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2011.09.049"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2005.01509.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2016.1163565"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10965-014-0628-8"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.12.023"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01569826"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328215614191"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(01)00248-6"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-3861(98)00546-1"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00093-0"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201700103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.201700103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:13:31Z","timestamp":1696338811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201700103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,2]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1002\/mabi.201700103"],"URL":"https:\/\/doi.org\/10.1002\/mabi.201700103","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,2]]},"article-number":"1700103"}}