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Curcumin (CUR) and 5\u2010aminosalicylic acid (5\u2010ASA)\u2010loaded silk fibroin (SF) membranes are coaxially electrospun onto the surface of a braided silk filament plug. The membranes show a predominant structure of random coil and silk I conformation. The concentration of CUR\/5\u2010ASA (weight ratio of 1\/1) in the SF solution is optimized to 0.4, 0.9, and 1.9 wt%. The morphologies, secondary structures, and in vitro drug release properties of the membranes are examined. Sectional images of fibers in the membranes show core\u2013shell structures. The coaxial electrospinning process does not alter the chemical characteristics of the drugs. The dual\u2010drugs encapsulated in the membranes are released in a steady and sustainable manner, and the cumulative release rate is improved by the increased drug loading. 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